Women are born with every egg they’ll ever have. The count falls from about a million to roughly 25,000 by 37, and the eggs that remain keep aging. No one can make a new one. That’s the timer on fertility, and why IVF gets harder with age.
@Conception says it just built a way around it. From a blood draw, they grew human eggs inside a tiny ovary also made from stem cells. The eggs have begun meiosis, the special division that halves a cell's 46 chromosomes to 23. That halving is what makes an egg an egg. A world first, they say. It matters because the starting cell is skin or blood, so ovarian age stops setting the limit.
The road here ran through mice. In 2016 Katsuhiko Hayashi's lab turned a mouse skin cell into an egg, then live pups. Humans stalled for years. Mitinori Saitou's team reached the egg's ancestor, but no one could build the follicle an egg ripens in or start meiosis in a dish. Conception says it cleared both.
These eggs only began meiosis. They haven't completed it, nothing's been fertilized, nothing published, no safety data.
If it holds, it reaches cancer survivors, women in early menopause, women who started late, two-dad families. Half the world, at every age. This could be truly revolutionary.
Et telefonnummer fra Philippinerne, ubehjælpsomt sprog, domænenavn helt i skoven og så Tysklands Odde, hvor jeg aldrig kommer. Falder nogen virkeligt for det her f*is? 🙄
"Schizophrenia is too complex to screen for."
That's what our client was told, so we whole-genome sequenced 7 relatives (incl one diagnosed with schizophrenia) and modelled the family history to analyze their three embryos in a way that's never been done before. Her results:
@herasight Thank you so much for helping us choose which one to transfer next! This is our fourth Herasight-informed transfer—so cool. Here are the three who made it out! They send their regards :)
Had @JonathanAnomaly on the podcast to discuss @herasight and the ethics of selecting embryos for intelligence, height, and other traits.
We get into radical life extension, and the broader philosophy of seeking ever greater control over biology. Jonathan shares a polarizing and inspiring view of what humanity can become.
0:00 Selecting embryos for intelligence and the taboo around it
7:39 Aging, death and status quo bias
14:29 Side effects of secularization
17:29 How a preference cascade will shift the Overton Window
22:40 The importance of biological intelligence post-AGI
29:53 In vitro gametogenesis, gene editing & fully synthetic human genomes
38:14 The rift between us and the upcoming enhanced generation
43:26 Nietzsche’s Übermensch, slave morality, and transhumanism
56:32 Longevity as our generation’s space race
Look up Free Radicals podcast on Spotify, Apple Podcasts, YouTube, etc. Follow me and @EricDai_BioE for weekly episodes.
Thank you to @SynBioBeta for hosting us!
@fredjacDK@Broccolidwarf@AlexVanopslagh Præcis. Man kan med fordel læse rapporten om strømafbruddet den 28. april 2025 på den Iberiske Halvø for at vide hvor vigtigt solid baseload er: https://t.co/5ZVip1N0rT