Naina McCann

Infectious diseases doc amongst other things. Interested in enteric fever, vaccines and global health.

[Naina McCann @nainasm168]

Results from our human challenge study out - two doses of the oral live attenuated vaccine CVD 1902 protects against infection from S. Paratyphi A. One step closer to a licensed vaccine against this pathogen which causes thousands of deaths every year. Thanks to all involved!

[NEJM @NEJM]

In a trial in healthy U.K. adults who were challenged with S. Paratyphi A in a controlled human infection model, two doses of the candidate vaccine CVD 1902 led to protection against S. Paratyphi A infection. Full VASP phase 2b trial results: https://t.co/YQNV1uWywN

[Naina McCann @nainasm168]

Great to speak at @BactiVac @MicrobioSoc meeting today on paratyphoid human challenge models and how they could help accelerate pathway to much needed paratyphoid A vaccines

[BactiVac Network @BactiVac]

Last scientific talk from @nainasm168 from @OxVaccineGroup @UniofOxford on human challenge models of paratyphoid infection & vaccination #BactiVacEvents #Vaccines4AMR @MicrobioSoc @Wellcome_AMR @bIGIdeas_UoB @UKgovGHS @britsocimm @unibirm_MDS

[BactiVac Network @BactiVac]

Last scientific talk from @nainasm168 from @OxVaccineGroup @UniofOxford on human challenge models of paratyphoid infection & vaccination #BactiVacEvents #Vaccines4AMR @MicrobioSoc @Wellcome_AMR @bIGIdeas_UoB @UKgovGHS @britsocimm @unibirm_MDS

[John Burn-Murdoch @jburnmurdoch]

NEW:

Britain’s grim winter of strikes, falling incomes and a worsening NHS crisis is not some unfortunate series of events

It’s the inevitable result of a decade of Tory austerity that steadily weakened the state’s capacity to respond to shocks

https://t.co/xJcNiCJk2b

Thread:

[Oxford Vaccine Group @OxfordVacGroup]

🚨 NEW JOB POST 🚨

Adult Clinical Research Fellow position available!

This is an exciting opportunity to join the team that have been working on the rapid clinical development of vaccines against COVID-19 & other key vaccine-related studies.

@OxPaediatrics | @UniofOxford

[Naina McCann @nainasm168]

Our paper summarising the last 11 years of enteric fever cases presenting to HTD is out! Showed majority managed as outpatients with good outcomes:

[The HTD @HTropDis]

HTD have looked at our last 93 cases of #EntericFever, mainly outpatients attending HTD’s travel walk-in clinic. We managed most patients entirely as outpatients (mainly with oral azithromycin), with good effect. More 👇
https://t.co/nvcLlegIqY

#typhoid #paratyphoid

[Muge Cevik @mugecevik]

As the monkeypox virus (MPX) outbreak continues, a lot of data emerging in real-time & being rapidly disseminated (as well as misinformation). I complied the unfolding scientific data (with direct links to papers and threads) on what we (don’t) know so far. #IDTwitter 🧵(1/n)

[Naina McCann @nainasm168]

For any Oxford dwellers...our paratyphoid challenge study is recruiting now to test a new paratyphoid vaccine - volunteers needed, see below

[Oxford Vaccine Group @OxfordVacGroup]

With a unique collaboration with the @UMmedschool we have begun recruiting for our new paratyphoid vaccine.

In the first study of its kind, after vaccination, our volunteers will be ‘challenged’ with paratyphoid to see whether the vaccine can prevent infection.

More info 🔻

[Michael Marks @dr_michaelmarks]

#COVID19 & Spo2 <94% w FiO2>=0.4 CPAP not HFNO decreased need ventilation @recovery_rs https://t.co/iixv0mxvIu Great see trials these key choices

[Naina McCann @nainasm168]

What a contrast

[David Lammy @DavidLammy]

This is how you do it! Senator John McCain giving a seminal gracious concession speech upon losing to Barack Obama. Reduced me to tears.

[Behzad Nadjm @BNadjm]

WANTED! Physicians w 3+ yrs PG experience. For work in clinical services @mrcunitgambia. Immediate start. ✈️ , 🏠 , registration, stipend. Great opportunity to experience tropmed under expert supervision. Pm if interested @EADTMH @LSHTM @RSTMH pls RT

[Professor Chris Whitty @CMO_England]

From today people should self-isolate if they develop a new continuous cough or fever or anosmia.

We have been monitoring emerging symptom data on COVID-19 and adding anosmia slightly increases sensitivity, and may lead to earlier isolation.

[Naina McCann @nainasm168]

Amen. They’ve been amazing 👏

[Keir Starmer @Keir_Starmer]

To mark #MayDay I'd like to thank all our brilliant key workers, especially the 47 newly qualified doctors who have come across the country and the world to work at the Whittington Hospital.

I nominate @DavidLammy, @AnnelieseDodds and @nick_forbes to #ThankAWorker.

[Professor Chris Whitty @CMO_England]

This is really important - if you need urgent medical care, the NHS is ready to help you. COVID-19 does not change this.

People who might be having a heart attack, stroke or life-threatening emergency usually do much better the faster they get medical care.

[Jake Dunning @OutbreakJake]

The reality of R0 explained, very clearly. #StayAtHome

[Naina McCann @nainasm168]

Useful resource of papers...

[Sachin J. Shah @sachinjshah]

I did a deep dive into the COVID literature scanning 1300+ PubMed articles. I put together what I think is a core group of papers for clinicians and medical educators.

You can access the library here: https://t.co/0JhP7AkmWY

Pls send me your feedback!

#FOAMed
#COVID19

[Muge Cevik @mugecevik]

#COVID19 hospitalisation and ICU admissions stratified by age group in the US:

- 20-44 age group: ~1 in 5 hospitalised, 1 in 20 in ICU
- 45-64 age group: ~1 in 3 hospitalised, 1 in 10 in ICU

The risk of severe disease and intensive care admission in young adults is not zero.

[Armando Iannucci @Aiannucci]

This is how the virus works. Read it and stay the fuck in. https://t.co/nmeqJ410dV

[Jake Dunning @OutbreakJake]

More great news in the fight against #COVID19! A European adaptive RCT of antiviral treatment is now recruiting & it includes the following arms: standard of care (SoC); SoC + remdesivir; SoC+ Kaletra; SoC + Kaletra + interferon-beta-1a. Well done to the trial team on launching.

[JP ✌️🌱 @JPetrides_]

Newsflash ⚡️ Downing Street are stockpiling with style! @allplants to the rescue for Carrie and Boris @No10 eating plants 🌱✌🏼