Serine Bouzouaoui, MD

PGY-3 Pathology Resident 🔬
Centre Pierre-et-Marie-Curie. 🇩🇿

[Charlie Herndon @DrCycloPath]

✅ Paraganglioma 🎯
• Neuroendocrine neoplasm of neuronal subtype showing classic Zellballen morphology.
• Characteristically negative for keratins and positive for GATA3.
• Strongly associated with germline mutations in SDH genes or VHL.
• All cases are considered to have a lifelong risk of metastasis.

[Pathology mcqs @Pathology_mcqs]

📌 34-year-old male with a retroperitoneal mass
The correct diagnosis is Paraganglioma — a highly vascular neuroendocrine tumor showing zellballen architecture.
#Paraganglioma #ZellballenPattern #RetroperitonealTumor #Histopathology #PathologyEducation #NEETSS #FRCPath #MedicalPG

[Dr sthanu subramanian @drsthanus]

The "zellballen pattern" is a characteristic histological feature, where tumor cells form small, rounded nests or "balls of cells" (zellballen in German) within a vascularized fibrous stroma, and is pathognomonic for paragangliomas.

https://t.co/OAMIQsD9mC

[Ahmed Montasser @AMontasserMD]

When tumors read books:
• At carotid body
• “zellballen” nested arrangement with prominent fibrovascular stroma
• Nuclear atypia but rare mitosis
• Melanin-like pigment

#Endocrine #Pathology #BenignIsBeautiful #Pathresident #PathClassic

[Jay "Thymocyte" Hwang @Path4People]

Insular Architecture

•Growth pattern comprised of tightly packed islands or nests
•May be seen in Neuroendocrine tumors and carcinomas, Poorly differentiated+medullary thyroid carcinoma
• Not to be confused w Zellballen pattern (has s100+ sustentacular cells)

#pathagonia

[Miruna Popescu, MD @MirunaPopescu13]

MPNST:
➡️ Sporadic, in NF1, or after RxT
➡️Hyper- & hypocellular areas
➡️Perivascular accentuation
➡️Uniform spindle cells
➡️Sometimes fibrosarcoma-like fascicular (🐟bone) growth
➡️+/- hyalinized, myxoid stroma
➡️S100, SOX10 focal, patchy or -ve
➡️Loss of nc H3K27me3

#BSTPath

[Vivi (traveling_pathologist) D.O. 🐈🐈‍⬛🌈🇨🇺 @path_girl88]

Oocytes staining for SALL4 in the ovary 🥰. #gynpath #pathtwitter #pathx

[Eman Magdy @EmanMagdy91D]

Glandular odontogenic cyst

Via notebooklm

#pathology

[Eman Magdy @EmanMagdy91D]

Pleomorphic adenoma

#pathology

[Jay "Thymocyte" Hwang @Path4People]

Adenoid Cystic Carcinoma (ACC)

Salivary Gland Tumor that is composed of both epithelial and myoepithelial cells.

Accounts for ~25% of primary salivary gland carcinomas

Can have a t(6;9) MYB::NFIB fusion.

Here’s ACC in a hard palate
Credit: Kelly Hall,MD
#pathagonia #pathx

[Jay "Thymocyte" Hwang @Path4People]

Salivary Gland Tumor: Adenoid Cystic Carcinoma (ACC)

• ~ 60% occur in major salivary glands
• Accounts for 25% of primary salivary carcinomas
• Median age ~60 y/o
• Genetics: t(6;9), MYB::NFIB
• Biphasic tumor (ductal+myoepithelial cells)

#pathagonia #path4people

[Aswathy Menon @dr_amenona]

Just a picture to appreciate classic morphology of Adenoid cystic carcinoma. Sometimes I forget to look at the finer details in more 'commonly' seen entities
#headandneckpath #PathX #Pathresidents #PathTwitter

[Elizabeth Montgomery, MD @LizMontgomeryMD]

This is a nice example of hepatocellular carcinoma in a cirrhotic liver that shows the pattern of endothelial cells wrapped around tumor cell groups and the beautiful reticulin distribution in the tumor and the adjoining cirrhotic liver.

[Ziad El-Zaatari @ziad_zaatari]

🔬 Ground Glass Hepatocyte Inclusions ~ Can be seen in Hepatitis B, Drugs, and Transplant Recipients ~ #GIpath #LiverPathology #Hepatology #Pathology

[Aatur Singhi, MD PhD @PancPathologist]

A Whipple is not only done to remove #PancreaticCancer; but, under certain instances, to remove a high-risk precursor neoplasm. In this case, a Main Pancreatic Duct Intraductal Papillary Mucinous Neoplasm (IPMN) #Pathology #GIPath #PancreaticCysts #PancreaticCancerAwarenessMonth

[HackDentistry @hckdentistry]

Did you know the differences between orthokeratinized odontogenic cyst and odontogenic keratocyst? Well, if you ever wanted to dive deeper 👉 https://t.co/Sj8aTrQhnN
#hackdentistry #dentistry #oralpathology #oralmedicine #odontogeniccyst #orthokeratinizedodontogeniccyst #dental

[anapath 2c @2cAnapath]

La biopsie confirme le diagnostic d'hépatite alcoolique aigue, en mettant en évidence la présence d'hépatocytes ballonisés, clarifiés avec corps de Mallory, de stéatose et d'un infiltrat polymorphe

[Manana Jikurashvili @M_Jikurashvili]

Reminder: In children, the liver cells are arranged in two-cell-thick plates. The presence of two-cell-thick plates and rosette formation in adults indicates hepatocyte regeneration.
Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract and Pancreas, 3rd Ed.

[Serine Bouzouaoui, MD @nanapath97]

@M_Jikurashvili The rosettes look like what exactly in the liver ?

[Jen Findeis-Hosey, MD @JFH_Path]

Like a jigsaw puzzle! Biliary-type cirrhosis in a patient with end-stage liver disease due to PBC (trichrome stain). #pathology #gipath #liverpath @GIPathologyURMC