Neesha Dhani

Chemo doctor, hypoxia scientist and mom. Realistic optimist striving for that elusive work-life balance and making cancer a chronic disease.

[Nicholas Hornstein @GIMedOnc]

#ASCO26

This one is special.

This is the hottest paper of 2026 and potentially in the history of pancreatic cancer.

Let’s dive in.

RASolute 302: Daraxonrasib vs investigator’s choice chemotherapy in previously treated metastatic pancreatic cancer
Abstract LBA5 (soon!)
Presentation: May 31, 2026, 3:21-3:33 PM CDT

For decades, pancreatic cancer has been where good ideas go to die.

We have optimized chemotherapy. We have sequenced chemotherapy. We have celebrated modest gains.

But the central driver of PDAC has always been sitting there in plain sight:

RAS.

More than 90% of pancreatic cancers have oncogenic RAS mutations, and until recently, we had essentially nothing direct to do about it.

Daraxonrasib is an oral RAS(ON) multiselective inhibitor targeting the active GTP-bound state of mutant and wild-type RAS.

And in RASolute 302, it delivered.

Quick hits:

📌 Phase 3 international randomized trial 500 patients with previously treated mPDAC Daraxonrasib vs investigator’s choice chemotherapy

🧬 RAS G12 population
91.8% of patients had RAS G12 mutations

📈 OS in RAS G12 population
13.2 vs 6.6 months
HR 0.40
P<0.001

📈 OS in overall population
13.2 vs 6.7 months
HR 0.40
P<0.001

📊 PFS in RAS G12 population
7.3 vs 3.5 months
HR 0.45
P<0.001

📊 PFS in overall population
7.2 vs 3.6 months
HR 0.49
P<0.001

🔥 12-month OS
Overall population: 53.2% vs 17.3%

⚠️ Toxicity matters, but this was not just more efficacy for more toxicity
Grade ≥3 AEs: 61.8% vs 69.6%
TRAEs leading to discontinuation: 1.2% vs 11.2%

This is the kind of survival curve we almost never get to see in pancreatic cancer.

This validates RAS(ON) inhibition in the most RAS-addicted major cancer. It takes a target we have talked about for decades and turns it into a clinically meaningful survival benefit in a randomized phase 3 trial.

The next questions come fast: 1L combinations, maintenance, perioperative disease, sequencing, resistance, toxicity management, and whether this becomes a new backbone.

RAS is here, and it couldn’t have come sooner.

https://t.co/Y4WJRlRRTk

@TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO
@NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc

[Harold J. Burstein, MD, PhD, FASCO @DrHBurstein]

1/ the @NHS-Galleri trial is 1st RCT for molecular screening for early cancer detection. 142K participants; found ~1400 cancers overall (i.e. 1% ). No sig reduction in incidence rates of stage III/IV cancers. No change in rate @ prevalent vs incident rds.

[WeBelieve @WeBelieveEM]

Carter Hart is about to play in the Stanley Cup Final. He was acquitted of sexual assault charges this past summer, but there is a lot more to the story. With the brightest lights now shining on him, it is important to understand the nuance of the controversial case.

“We Believe E.M” does not mean we believe every detail of her testimony. It does not mean we believe she did not make any mistakes that night. It simply means we believe she was sexually assaulted. And the evidence supports that belief.

I will leave you with some facts. This is all available if you research (tw // sa):

- There is ZERO evidence or testimony that EM ever asked Michael McLeod to invite additional men to that hotel room. McLeod never testified, and all we have is a video interview with police where he never made that claim, meanwhile LYING when he denied sending a text invite to ALL his teammates. On the otherhand, there is text evidence the following day of EM telling McLeod she did not expect more partners, and it was not disputed by McLeod.

- There is ZERO evidence or testimony that EM ever asked (or was asked) for Cal Foote to do the splits over her. Even if you believe the men’s story that she was saying “have sex with me”, she never said “teabag me”. The judge actually agreed in her report there was no consent, instead she dismissed it saying it was non-sexual based on Carter Hart’s testimony that Foote was not naked.

- In 2022, Alex Formenton & Dillon Dube BOTH CONFESSED to Hockey Canada that Cal Foote was naked during the splits. This was ruled inadmissible on a technicality. Other than Hart, no other witness dared to say Foote was clothed; they all pretended to not remember.

With this information, at the very least, McLeod and Foote are guilty:

- Foote performed a sexual act without consent. It does not make him a rapist, but it is a crime

- McLeod is an accessory to that sexual assault

If these two men were given the guilty verdict I strongly believe they deserved (even if it was a proverbial slap on the wrist; i.e. a 6-month house arrest), it would have been an amazing teaching moment for our nation while setting a modern standard for consent.

The conduct of the others, including Hart, may not have been illegal. There was certainly not enough evidence to prove it was. But that does not mean what they did wasn’t morally reprehensible. The NHL and Hockey Canada both agreed.

The NHL kept the players out of the league for months PAST the ruling, citing their own private investigation. Hockey Canada stood in the House of Commons and said “harm was caused” after paying out a civil settlement.

But what Hart did was more than morally wrong. He lied under oath to protect his teammates. This is actually perjury. The judge by law is not privy to those 2022 confessions, but we as a public are. We are allowed to pass judgement in the court of public opinion.

Hart is not a conquering hero who overcame adversity. He is a liar who abused his privilege and legal protection to obstruct justice. He is allowed to continue his career, and we are allowed to remind him of his abhorrent behaviour.

[Neesha Dhani @ncdhani]

Sunny vibes this Mother’s Day, started the day with a nice run @UofT campus and now @TorontoMets baseball with @RoShowBaseball. After games cancelled for rain yest, the baseball Gods must be moms! ☺️💕

[Rohan Persad @RoShowBaseball]

Got the start for @TorontoMets @CPBLeague 3.0 IP 7 Ks 0 ER. Looking forward to the next game! @richleitch47 @RDM_26 @DuncanWatt19 @ding3722 @PrepBaseballON @JoshArcePB @CamAraujoPB

[Rohan Persad @RoShowBaseball]

Pre-season clips. Timely triple in one game and 3 Ks over 2 innings in another. @TorontoMets @CPBLeague @richleitch47 @RDM_26 @DuncanWatt19 @ding3722 @PrepBaseballON @JoshArcePB @CamAraujoPB

[NEJM @NEJM]

In a patient with metastatic cervical cancer treated with the nectin-4–targeted antibody–drug conjugate bulumtatug fuvedotin, a new hepatic lesion proved to be pseudoprogression and resolved with continued therapy. Read the full case details: https://t.co/1WpwH9XOdz

[Prep Baseball Ontario @PrepBaseballON]

𝐎𝐧𝐭𝐚𝐫𝐢𝐨 𝐅𝐮𝐭𝐮𝐫𝐞 𝐆𝐚𝐦𝐞 𝐓𝐫𝐢𝐚𝐥𝐬

SS/RHP Rohan Persad
2027, @TorontoMets
@PB_Uncommitted

5-foot-11, 180-pounds.

Peak EV - 89.3 mph
Max Dist - 320 feet
Sweet Spot % - 53
Hand Speed Avg/Max - 18.6/20.1
Bat Speed Avg/Max - 67.2/71.5
Rotational Acc Avg/Max - 16.4/21.1
INF Velo - 90 mph

@RoShowBaseball | #FGT26🇨🇦

[JAMA @JAMA_current]

"Medicine can have extraordinary meaning. But it cannot substitute for being present in your own life."

In #APieceofMyMind, a psychiatrist and residency program director reflects on an unexpected #LungCancer diagnosis.

https://t.co/V3Tae6P6mU

[Prep Baseball Ontario @PrepBaseballON]

𝐎𝐧𝐭𝐚𝐫𝐢𝐨 𝐅𝐮𝐭𝐮𝐫𝐞 𝐆𝐚𝐦𝐞 𝐓𝐫𝐢𝐚𝐥𝐬

SS/RHP Rohan Persad
2027, @TorontoMets
@PB_Uncommitted

5-foot-11, 180-pounds.

FB 80-82 | 9.3 IVB | 4 HB
SL 69-71 | -8.6 IVB | -16.1 HB
CH 70-72 | 14.8 IVB | 10.8 HB

@RoShowBaseball | #FGT26🇨🇦

[Rohan Persad @RoShowBaseball]

A few highlights from Spring training in #Florida @RussMattFL with @TorontoMets @CPBLeague Clip 1- Double to force a mercy Clips 2,3
- Pitched a scoreless 5 innings to help secure a W. @RDM_26
@DarrylReid2066 @schachow @richleitch47 @DuncanWatt19
@ding3722 @dbails20

[LeafsJellyHD @LeafsJelly]

Not sure why Sportsnet hasn't posted it, but an unbelievable opening montage

[Sportsnet @Sportsnet]

A season we’ll never forget 🫶

[Jon Levett @jonlevett]

It's #OpeningDay for the #BlueJays50 ! Here's "All These Things That I've Done" by The Killers to get you set. @Sportsnet @BlueJays

[Ben Verlander @BenVerlander]

This is incredible

The Blue Jays celebrate 50 years of history 🇨🇦

[EJ @ejmb0000000]

Daniel Palencia tearing up before even throwing the last pitch is absolutely incredible

[Neesha Dhani @ncdhani]

Good catch @RoShowBaseball @WBCBaseball finals game! Now time for a pre-game cocktail!

[Neesha Dhani @ncdhani]

@RoShowBaseball caught a ball at batting practice @WBCBaseball finals! Now time for a pre-game cocktail!

[Harriette Van Spall, MD MPH 🇨🇦 @hvanspall]

He was a mentor

But departing from evidence, he had my dad w new angina wait 4wks for CABG: Cath/IVUS had shown 70% LM, tight ostial LAD+LCx lesions, RCA occlusion

My beloved dad died before CABG

The ensuing silence left me w #lessons I carry everyday1/
https://t.co/vxkKTIeenh

[Bishal Gyawali, MD, PhD, FASCO @oncology_bg]

New episode of our podcast Grounded in Groundshot is out!

In this episode we discuss with Prof @EAEisenhauer about far ranging topics including work-life balance, running clinical trials, mentorship, women in oncology, RECIST criteria, etc.
I can assure you that you’ll find this episode most insightful, educational, and inspirational.
I guarantee you this is worth your time. You learn more in 1 hour with @EAEisenhauer than in years of your fellowship!

▶️ YouTube - https://t.co/Lan5ZhkmDI
▶️ Apple Podcasts - https://t.co/tWizlwK674
▶️ Spotify - https://t.co/itD0xVtRij