Biopharma consultant. Interest topics - Biosimilars, oncology & immunology. Posts/tweets here are personal and DO NOT reflect/represent the views of my employer
#AACR23 is just around the corner!
From the multiple data sessions, Course5i selected a few data that will showcase clinical and preclinical results of promising new IO targets and emerging modalities in cancer research. #solidtumors#oncology#immunotherapy#CancerResearch
#SITC22 Updates: $ABBV’s ABBV-151 (GARP-TGF-β1 mAb) + budigalimab (PD-1) showed ORR 16% & 8% in the PD-1 R/R UC & PD-1 naive MSS-CRC expansion cohorts resp.; manageable safety profile – Positive data to support Ph2 plans in these indications
#CRC#immunooncology#CancerResearch
#SITC22 Updates: Remarkable ORR of 69% (9/13 pts) for Oncolytic Biotech's #pelareorep (oncolytic reovirus) +atezolizumab+chemo in pancreatic cancer, >2x rate vs ~25% for historical controls – warrants further evaluation in this setting
#PancreaticCancer#oncology#CancerResearch
$AZN (#AstraZeneca) Q2 results
Early-stage #oncology pipeline- Adavosertib (WEE1 inhibitor) in Ph2 removed due to safety concerns
#Zentalis’ Zn-c3 leads among #WEE1 inhibitors in solid #tumors with pivotal trials -> FDA discussion ongoing
https://t.co/pQO4LJOImc
Great to see the much awaited MOMENTUM data masterfully presented by @mpdrc at #ASCO22. Key points: min TSS 10, max Hgb 10 at baseline, median prior JAKi 2+ y. 130 MMB (200 mg/d), 65 DAN (600 mg/d). Week 24 TSS50 25% vs. 9%, SVR35 23% vs. 3%, TI 31% vs. 20%. PN 4% vs. 2%. #mpnsm
My only two #ASCO22 predictions this weekend (and admittedly these aren't going out on a limb).
1. Enhertu will be ASCO22's biggest news.
2. Tropics-02 will be so bad (< 1 month PFS).
I'm intrigued to see the adicet gamma delta update. Also, a big moment for CD3 bi-specifics.
@Dr_AmerZeidan @CCO_Education Great talks! Thank you! Missed seeing the panel online.. guess that was a perk only for those who were live at Marriot Marquis.
"Yesterday I went to Peppa Pig World... I loved it, it's very much my kind of place"
PM Boris Johnson tells CBI conference "no Whitehall civil servant would conceivably come up with Peppa" as he praises the "power of UK creativity"
https://t.co/jtIu0zy7g3