Neha Malhotra

Project Scientist at UCSD. Working on Antimicrobial Discovery.

[Neha Malhotra @nehastar03]

@biorxiv_micrbio Environmental fungi target thiol homeostasis to kill Mycobacterium tuberculosis. A coculture mediated approach to elicit the production of anti-Mtb molecules from environmental fungi, which kills Mtb by disrupting thiol homeostasis: https://t.co/yRlWAGVd6K

[mBio @mbiojournal]

Oxidative protein folding is a crucial process for #mycobacteria. Disulfide bonds are critical for stabilizing cell division, cell envelope biogenesis, and antibiotic resistance proteins in mycobacteria. https://t.co/cE62DrmWi3

[RootPath @RootPathGx]

We are excited to share another #MegabaseSpark submission, from @nehastar03: "We bioengineer microbial biosynthetic gene clusters (BGCs) to unlock cryptic pathways and discover novel antimicrobial compounds. Using heterologous expression and rational design, we aim to produce potent and structurally diverse bioactive metabolites." Like and repost if you think this idea is interesting! #SynBio #SyntheticBiology #DNA

[Nature Reviews Microbiology @NatureRevMicro]

New online! Antimicrobial peptides: structure, functions and translational applications https://t.co/WZSzOCk6ys

[AMR Action Fund @AMRActionFund]

A new paper modeled the impact that various climate change scenarios could have on fungal pathogens and patients in Europe. Under one scenario, Aspergillus fumigatus could increase by 77.5% and potentially expose 9 million people in Europe https://t.co/sAQBQ2lWMQ #AMR

[Babak Javid @javid_lab]

Rapid tuberculosis diagnosis from respiratory or blood samples by a low cost, portable lab-in-tube assay | Science Translational Medicine https://t.co/juY4vZwImG

[Nature Chemical Biology @nchembio]

The long-mysterious gene cluster for the biosynthesis of a decades-old antibiotic negamycin has been identified and characterized to reveal a heme-dependent enzyme that directly couples glycine and nitrite to form the unusual N-N bond in negamycin

https://t.co/7oqhGuUgc3

[Neha Malhotra @nehastar03]

Scientists ponder the peat bog to fight TB | C&EN Global Enterprise https://t.co/LDzCND269h

[Nature Microbiology @NatureMicrobiol]

Emergency bulletin! 14 journals have co-published an urgent call for the deployment of microbial solutions against climate catastrophe, by @peixotors et al.
https://t.co/yYQZO4Gm6b

[PLOS Biology @PLOSBiology]

#Fungi & #mycobacteria are both found in sphagnum peat bogs. This study screens bog fungi for inducible #antitubercular activity, identifying 3 distinct natural products that induce a thiol stress response in Mycobacterium #tuberculosis #PLOSBiology https://t.co/SaBVwwWyht

[Olivier Duss @OlivierDuss]

First paper of our lab today @Nature by Nussi!

We provide a real-time movie on how #transcription and #translation cooperate using multi-color #single-molecule FM: we find long-range #ribosome-#polymerase communication mediated by #RNA looping! @embl

https://t.co/ui1h01VaQW

[Brian Roemmele @BrianRoemmele]

“Peat-bog fungi produce substances that kill tuberculosis-causing bacteria”

https://t.co/Ds5gjHc69Z

[Neha Malhotra @nehastar03]

New tuberculosis cure could come from fungi found in US bogs https://t.co/bG7cEv2I5Q

[Neha Malhotra @nehastar03]

Tuberculosis Bacteria Vulnerable to Substances from Peat Bog Fungi https://t.co/sdF5HUE7Ms via @GENbio

[Neha Malhotra @nehastar03]

Peat-bog fungi produce substances that kill tuberculosis-causing bacteria https://t.co/3YMu27izj9

[Neha Malhotra @nehastar03]

Scientists Discover a Hidden Weapon Against TB in Peat Bogs https://t.co/8lr2jK9mfx . Find the original article here: https://t.co/yRlWAGUFhc

[Neha Malhotra @nehastar03]

Preprint of our interesting study is available here: Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis https://t.co/Q25sSmTDMI
#Tuberculosis #Mtb #sphagnum #fungi #Natural_products #biorxiv #drug_discovery

[Neha Malhotra @nehastar03]

Preprint of our interesting study is available here: Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis https://t.co/Q25sSmTDMI
#Tuberculosis #Mtb #sphagnum #fungi #Natural_products #biorxiv #drug_discovery

[bioRxiv Microbiology @biorxiv_micrbio]

Environmental sphagnum-associated fungi target thiol homeostasis to compete with Mycobacterium tuberculosis. https://t.co/o0QW3SMBD3 #biorxiv_micrbio

[Neha Malhotra @nehastar03]

Stop making India a political hub. It can be YOU, ME or anybody in d neighborhood tomorrow like it is martyrs today #khoonkidalalifight