🧵New preprint! How does an elongating RNA polymerase deal with a DNA-bound transcription factor in its path?
We developed a label-free single-molecule assay that detects RNAP arrival by suppression of fluctuations in a partially unzipped DNA fork.
https://t.co/L8Oscmt02P
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I'm trying to win a DS-11 FX+ Spectrophotometer / Fluorometer from @denovix, recipient of the SelectScience Diamond Seal of Quality! https://t.co/BoeWjCoI7x #DeNovix#DiamondDS11
Postdoctoral fellowships from the Azrieli Foundation.
Join us to use cutting-edge single-molecule biophysics to study transcription regulation!
https://t.co/sG37VjgIde
**לא בבית ספרנו** סגל הטכניון יוצא במסר תמיכה חד משמעי בסטודנטים/ות ועובדי/ות הטכניון, תהיה דתם, נטייתם המינית וזהותם המגדרית אשר תהיה ומתנגדים להפצת שנאה, היררכיה הדרה ולהפרדה מגדרית .
https://t.co/zNjck3Kiw8
Interested in single-molecule methods to study #chromatin dynamics and #transcription?
We have a #postdoc opening in the lab, and the Zuckerman Postdoctoral Fellowship is an excellent opportunity.
https://t.co/Itl4mtfXuX
For more info: https://t.co/em4X1TXdkY
During nucleosome passage, Pol II causes loss of H2A-H2B dimers from the nucleosome, resulting in hexasome formation. We provide structural evidence for this process and observe that Pol II backtracks upon encountering nucleosomal barriers @MolecularCell.
https://t.co/FVvsNUKPu9
How do ATP molecules rapidly reach their catalytic sites in the ultrafast helicase RecBCD?
Our new publication, in collaboration with Arnon Henn’s and @KleifeldO, is now out in @NatureComms:
“Auxiliary ATP binding sites support DNA unwinding by RecBCD” 1/n
https://t.co/hxGV7Ii8Lh
Single molecule characterization of the binding kinetics of a transcription factor and its modulation by DNA sequence and methylation https://t.co/p1DkKuqDN1 Congratulations @Hadeel_Khamis8!