N Molecular Systems

[N Molecular Systems @Nth_step]

Recent advances reveal architecture of energy transduction systems in pathogens.

Heme transporter CydDC promotes assembly/maturation of cytochrome bd (target for development of novel therapeutics).

Cover depicts CydDC/heme embedded in bacterial bioenergetic membrane milieu.

[N Molecular Systems @Nth_step]

(1/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA.

Checkout this intriguing work!!

Structure and mechanism of Zorya anti-phage defence system.
Nature (2025)

Image for: @NMITaylorLab
Created by: N Molecular Systems | @Nth_step

[N Molecular Systems @Nth_step]

(2/3) Molecular defense systems: bacteria deploy motorized spindles to entangle & degrade viral DNA.

Checkout this intriguing work!!

Structure and mechanism of Zorya anti-phage defence system.
Nature (2025)

Image for: @NMITaylorLab
Created by: N Molecular Systems | @Nth_step

[N Molecular Systems @Nth_step]

(3/3) Molecular defense systems: bacteria deploy motorized spindles to trap & degrade viral DNA.

Checkout this intriguing work!!

Structure and mechanism of the Zorya anti-phage defence system.
Nature (2025)

Image for: @NMITaylorLab
Created by: N Molecular Systems | @Nth_step

[N Molecular Systems @Nth_step]

Molecular mechanism of substrate recognition and cleavage by human γ-secretase ▼ Science

https://t.co/uQ9EU23ANR

[N Molecular Systems @Nth_step]

"Dissecting the conformational complexity and mechanism of a bacterial heme transporter" | A passage for heme | Nature Chemical Biology, August 2023 Vol. 19 No. 8

Open Access pdf:
https://t.co/a83WaFUVIh

EMD-14640 | 7ZDB, ...
https://t.co/BE4DBrZ9pq

[N Molecular Systems @Nth_step]

HEME TRANSPORTER. Decades-old enigma in bioenergetic membrane biogenesis.

Max Planck's @MPIbp @SafarianSchara et al resolved CydDC in 23+ states/conditions 2.7-3.9Å by cryoEM, probing heme structural dynamics via mutations, 20 MD simulations.

Image (2021, version B): @Nth_step

[N Molecular Systems @Nth_step]

Thank you to Max Planck @MPIbp and to Nature @nchembio for selecting the cover. It looks great in print!

Congrats to all for the great work @MPIbp @ALIFE_VU @UGent @UniKent @MiChAeL_900922 @AhmadRezaMehdi1 @franziska_f1nke @sonjawelsch @ShepherdLabKent @HummerLab @SafarianSchara

[Max Planck Institute of Biophysics @MPIbp]

The role of CydDC, a potential target for new antibiotics, in the bacterial energy metabolism has remained nebulous for decades. Scientists from our Institute, @ALIFE_VU, @UGent, @UniKent solved the riddle: CydDC is a heme transporter👉https://t.co/qqkC21S97a
#biophysics #cryoEM

[N Molecular Systems @Nth_step]

@SafarianSchara @MiChAeL_900922 @franziska_f1nke @AhmadRezaMehdi1 @HummerLab Truly elegant work.

"Dissecting the conformational complexity and mechanism of a bacterial heme transporter" | Nature Chemical Biology

Open Access:

https://t.co/a83WaFUVIh

[N Molecular Systems @Nth_step]

Congratulations to Safarian lab at Max Planck @MPIbp !!

It was a real pleasure working with you!
@SafarianSchara @MiChAeL_900922

https://t.co/gmt8HdEOMT

[N Molecular Systems @Nth_step]

Congrats to @NogalesLab @Yildiz_Lab on insights into MAP7 & Kinesin-1 https://t.co/wJW8uNF0XB

A warm flashback to our formative model (vis-a-vis 2018 "Microtubules: From Atoms to Complex Systems", EMBL) in collab with Ori-McKenney lab.

#MAPs #kinesin #microtubules #cellpolarity

[N Molecular Systems @Nth_step]

Our collaboration on PYRD 310-helical element implicated in human disease & conserved in kinesin superfamily molecular motors, with McKenney/@ucdavisbiology @GennerichLab/@EinsteinMed Niwa/@TohokuUniPR

#AccelerateResearch, please read
https://t.co/YP6zURj3rI

@KIF1A #KAND #KIF1A

[N Molecular Systems @Nth_step]

Intriguing aspect of the work @A_Amunts is 20Å gap between exit / insertase, providing for additional factors and #proteinfolding milieu (which differs from bacteria that favor early compaction of TM helices). We visualize 32 AA of #MTATP6 here (red) in place of poly-Ala in 6zm5.

[N Molecular Systems @Nth_step]

If a machine could talk to us, what would it say?
#beautifulmachine #code #recursion #dance

https://t.co/PSjofuJalF