Anna Obraztsova

Computational immunologist @Genentech
@obrzts.bsky.social

[Teddy Yewdell @TYewdell]

The Yewdell Lab @genentech is seeking a summer intern for 2026!! An excellent opportunity to learn how we combine fundamental, basic research with drug discovery to create novel therapeutics, and to see what biotech is all about. Apply now! https://t.co/NPF0WZOpMW

[Anna Obraztsova @obrzts]

Summer 2026 internship @genentech! Join us in South San Francisco to help advance cancer treatments through computational biology. MS and PhD students welcome
https://t.co/WpPdVqN9eT

[Waggoner Lab @LabWaggoner]

Fibroblastic FLT3L supports lymph node dendritic cells in the interfollicular niche @NatImmunol @sunnyz_wu
@genentech @TurleyLabGNE @SorenMuller1
https://t.co/5uLFMUMjWW

[Anna Obraztsova @obrzts]

@iskander What if the heavy drinkers were the ones given a poorer prognosis? Self-fulfilling prophecy

[Paul G Thomas @PGTimmune]

TCR repertoire dream: decoding immune status by sequencing TCRs. Problems: 1) Need paired TCRab chains 2) Interesting T cell clones are often VERY small. Our solution: TIRTL-seq 🐢Deep, quantitative, & affordable paired TCR repertoire sequencing. 🧵 https://t.co/n90d3DLZHV (1/11)

[Waggoner Lab @LabWaggoner]

Mechanistic framework of how antibodies can optimize protective immunity, regulating B cell response participation and duration in a way that can be harnessed for vaccine design @ImmunityCP @isaak_quast
https://t.co/DA8VPZdQ5q

[Prof. Nikolai Slavov @slavov_n]

One of the most important things to know is to know when you know and when you do not know.

[Anna Obraztsova @obrzts]

@iskander Wow! We had fewer but also from a much smaller sample. Could it possibly be anything other than clonal cells?

[Anna Obraztsova @obrzts]

Would be cool to map out what's the overall landscape of antigen reactivity of human memory B cells, and what vaccines/pathogens cross-reactivate what

[Anna Obraztsova @obrzts]

In new preprint we delve into early memory B cells which are the frontline in generating antibodies against a familiar threat. We found that after first COVID vaccination a lot of pre-existing memory rapidly makes antibody-secreting cells despite weak binding to the viral protein

[Anna Obraztsova @obrzts]

Like others have shown, many pre-existing memory B cells against SARS-CoV-2 don't recognize common cold coronaviruses – the main suspect for triggering the generation of these cells

[Anna Obraztsova @obrzts]

Academics be like "it all started with a very simple question" and then hit you with a profound Q you'd never dream about

[Anna Obraztsova @obrzts]

Bioinformatician

[Danny @Danny_]

What are you called when all of your non-technical friends think you're technical and all of your technical friends think you're non-technical?

[Anna Obraztsova @obrzts]

@Arien_Schiepers @biorxivpreprint Beautiful experiments! What do you think about why antibody feedback doesn't stop MBCs from generating PBs after boost?

[Anna Obraztsova @obrzts]

@agalitzina Unfortunately not 😅

[Anna Obraztsova @obrzts]

Bulk vs single-cell

[Anna Obraztsova @obrzts]

@ejvillablanca It's time to take a step further and stop writing the bricks altogether