Samuel Opatowski

Founder of Orbittat | Building ecosystems and constellations powered by AI & technology

[Claude @claudeai]

Introducing Claude Sonnet 5.5, the second model in the Claude 5.5 family.

It’s a clear upgrade over Sonnet 5, runs more than 30% faster, and costs up to 30% less for most work.

[Andy @PositivFuturist]

It’s just a stochastic token predictor.

[Anthropic @AnthropicAI]

This is the first result from our new molecular biology lab, where a team of Anthropic biologists is using Claude to explore and accelerate fundamental biology research. There, Claude works through data and literature to generate hypotheses and candidate biological systems to study. After our scientists review Claude’s hypotheses, they test the most promising ideas, with all lab work done by our scientists.

We’d like to extend this approach to a broad range of problems—in genomics and in other fields. If you have a proposal for a research question, we’d like to hear from you.

[Dario Amodei @DarioAmodei]

Today we announced the Claude-led discovery of a molecular machine that we suspect could represent a new gene editing mechanism. Its precise function, biotechnological utility (if any), or level of significance is not yet clear, but at minimum it is work I would have been proud to do as a PhD student. The work was done mostly, though not entirely, by Claude: our life sciences team suggested a broad area of research, Claude read through the literature and a bunch of genome data and discovered something interesting, then Claude proposed experiments to verify the discovery and our team carried them out.

It’s easy to dismiss this as a one-off or curiosity, but we’ve repeatedly seen a pattern where AI performance in new intellectual domains goes from weak to superhuman in a matter of a few years. In 2023 models struggled to do math at the level of an average high-school student. In 2024 they started to do well on math competitions for the best high-schoolers in the country, in 2025 they started to solve minor open problems, in early 2026 more significant open problems, and in late 2026 they are beginning to solve the top few open problems in all of mathematics. We believe AI for biology is on a similar exponential trend.

The main difference between biology and mathematics, of course, is that math can be done purely theoretically, while biology requires experimentation. Some have used this to draw the conclusion that AI’s utility in biology will be limited. We think this is wrong. As we’ve demonstrated today, humans can collaborate with AI to perform the experiments, validate key results in a few weeks and, if necessary, work with the AI to iterate on what they find. Eventually it may even be possible for Claude itself to safely perform the experiments by autonomously controlling lab equipment, with appropriate safeguards in place, but we aren’t doing that today (our lab is also a BSL1/BSL2 facility that doesn't handle materials dangerous to humans).

More broadly, biomedical advancement has many stages — from fundamental biology discoveries, to translational research, to drug discovery, clinical trials, and finally the actual delivery of medicines and health care to patients. We are also interested in these later stages, but even simply accelerating the first stage of fundamental biological discoveries has the potential to speed up and broaden the entire pipeline. Improving our understanding of biology and sharpening biologists’ tools can drive forward all of the later stages, for example by identifying new drug targets, finding new therapeutic modalities, allowing for more precise measurement, and speeding up the experimental loop which itself further accelerates our understanding of biology. This will not in itself speed up clinical trial times, but if it succeeds it could greatly increase the number of promising candidates that go into the pipeline — an increase in throughput even though latency remains.

In Machines of Loving Grace, I wrote about AI’s potential to “cure most diseases in 5-10 years” — a goal that sounds impossible, but one I believe is just barely possible if AI is applied to every stage of the pipeline. The first step is showing that AI can first help with, and then drive, biological discoveries.

Claude’s discovery is the latest in a line of related prior work that goes back decades, beginning with systems like CRISPR, and continuing with discoveries like the bridge recombinase and VIPR in the past few years. Recently, there has been heightened interest in systems based on reverse transcriptase (RT) enzymes, the enzyme underlying the system Claude identified. And most recently, a Stanford team working independently described a novel RT system with an associated non-coding array that is in some ways similar to the one Claude found, though they are distinct systems that evolved independently from each other. I believe that we’re at the very beginning of finding such systems and developing them into powerful tools for biotechnology.

I’m proud of the resources Anthropic has invested in accelerating the public benefits of AI through the life sciences, and we’re aiming both to grow our life sciences team and to work with other scientists to extend this approach to a broad range of problems. If you have a proposal for a research collaboration or are interested in joining our life sciences team, please reach out.

[Anthropic @AnthropicAI]

Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.

We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.

Read more: https://t.co/RuEosScSMb

[Sam Altman @sama]

We want the OpenAI API to feature the best model at every price point and to be the best at every modality (text, code, image, video, etc).

And then we want you all to come up with great ideas and build them and to get to be happy users. The best ideas will come from you all.

[OpenAI @OpenAI]

Please welcome GPT-6 Sol and GPT-6 Luna to the GPT-6 universe.

GPT-6 Sol and Luna build on the advances behind GPT-6 Astra, bringing much of its strengths into faster and more affordable models to support work at scale.

We’ve also made caching and inference more efficient, and we’re passing the savings directly to you: 50% lower API prices for Sol and Luna compared with GPT‑5.6 promotional pricing.

[Claude @claudeai]

Introducing Claude Opus 5.5, the first model in our new Claude 5.5 family.

It performs at the level of Claude Fable 5.1 for most tasks, and costs 40% less to run than Opus 5.

[Tibo @thsottiaux]

We have been focusing on efficiency and intelligence for all.

Very proud of the team. Only possible when you have incredible models at the top end of the capability that you can then use to make a big difference in everything else.

[Samuel Opatowski @Opatowski01]

@thsottiaux Ready !!! LFG 😎🚀🚀🚀🚀

[Samuel Opatowski @Opatowski01]

@katiekirsch Would love to join!

[Brett Adcock @adcock_brett]

The holy grail for robotics is being able to generalize: doing work in unseen places

We rented 30 homes in the Bay Area and are doing tasks without any new training

[Diogo Almeida @CompleteSkeptic]

After co-inventing ChatGPT, I kept asking myself: why have superhuman chat models not led to AGI?

I’ve spent the last 2 years in stealth building a new way to train models (RLCD), and a new type of frontier AI model that we are releasing today: Jev

• 20-200x faster
• 40-400x cheaper (w/ output tokens free)
• Frontier composable intelligence optimized for decisions

AFAICT the shortest path to AI-based economic revolution

[Samuel Opatowski @Opatowski01]

@LDT0545 $300 for unlimited frontier-level intelligence with Codex? Brother, people pay more to feel something at Coachella.

[Samuel Opatowski @Opatowski01]

@MatthewBerman @bot @SpaceXAI Thank you 🙏

[Samuel Opatowski @Opatowski01]

@alecwilcock Here
https://t.co/ECfuR5mtjM

[Samuel Opatowski @Opatowski01]

@imanebrahimi 😂😂

[Samuel Opatowski @Opatowski01]

@DavidOndrej1 Yes!! And Fast very fast

[Samuel Opatowski @Opatowski01]

@DotCSV First mathematics.
Then science.
Then the world changes.