Open Genome

Biomedical AI meets Web3 on Solana. Analyze your health signals, mint the report as a NFT and shop evidence-based herbal supplements. ClinicalTrials-registered.

[Open Genome @Open_Genome]

$oGNOME utility token of OpenGenome on Solana mainnet.

CA: E2mphwn17yszY9BjPaqPfZ5qmAgo1oWALTCu8me5pump

Tokenomics:
• Used to mint biomedical reports as NFTs on-chain
• Payment currency for OpenHerb supplement marketplace
• Every transaction: 93% to seller, 7% to treasury
• Treasury auto-burns every 1M oGNOME accumulated, reducing supply permanently

Links:
Platform: https://t.co/kZ5SpRht78
Shop: https://t.co/UjgMbqXTVa
Token utility: https://t.co/BCT2t02mx3

[Open Genome @Open_Genome]

OpenGenome is a biomedical signal analysis platform built on Solana

We describe what we are doing as Decentralized Science, or DeSci. That word is not branding. It is a description of how this project actually works.

There is no venture capital firm behind OpenGenome. There is no lead investor holding a large allocation who can exit when the price suits them. The funding, the data, and the direction of this project come from the community that participates in it. People who contribute their biomedical signal data are not users in the traditional sense. They are contributors, and their contribution is recorded permanently on-chain in a way that cannot be altered or taken from them.

This is a deliberate choice. Most biomedical research today is shaped by whoever funds it. When funding comes from institutions that need a financial return, that influences what gets studied, who owns the results, and who benefits from them. DeSci is a direct response to that. When funding and knowledge come from the community, the community also holds what gets built from it.

Our observational study is registered on https://t.co/k3jXV0MLMd under identifier NCT07578610, and is indexed by the WHO International Clinical Trials Registry Platform (ICTRP).

Study name: OGNOME-OBS-2026-001
Status: Actively recruiting
Target participants: 10,000
Period: May 2026 through May 2028

https://t.co/k3jXV0MLMd is operated by the U.S. National Library of Medicine. Getting listed there requires submitting a structured protocol that is publicly searchable by anyone. It is not a paid placement and it is not self-reported.

To give that context: two other organizations in the same registry are Eli Lilly and Company, a 150-year-old S&P 100 pharmaceutical company with $65 billion in annual revenue (https://t.co/Q2s1BAukq3), and Spectrum Pharmaceuticals, a Nasdaq-listed oncology company with $109 million in annual revenue (https://t.co/MvUUlxjkIp). We are not the same size as these organizations. The verification standard applied to their submissions, however, is the same standard applied to ours.
Eli Lilly and Spectrum Pharmaceuticals are mentioned here purely as context to illustrate what https://t.co/k3jXV0MLMd registration means in practice. We are not positioning ourselves as competitors to either organization, and we have no affiliation with them.

$oGNOME is the utility token of the OpenGenome protocol. It is used to access Wellness Guidance, the Herb Directory, and the Herb Marketplace. Marketplace transactions split 93% to the vendor and 7% to the protocol. Every transaction generates a compressed NFT receipt on-chain as a permanent record.

Platform: https://t.co/kZ5SpRht78
Blog: https://t.co/Hk9Bcymlgg
NCT07578610 registration announcement: https://t.co/ozHwqchimL
https://t.co/k3jXV0MLMd registry page: https://t.co/FA7kb7v26O
oGNOME token utility: https://t.co/BCT2t02mx3

[Open Genome @Open_Genome]

We were here at $5k market cap on the pump(.)fun bonding curve before most of you knew this existed. We are still here now. The people calling this a scam today were not here building the clinical registry, shipping the NFT minting system, writing the API endpoints, seeding 67 herb products into a live marketplace, or getting NCT07578610 registered with https://t.co/k3jXV0MLMd. We were. Every single day since launch.

Let us be clear about something. We never asked anyone to buy. We never ran a campaign telling people to ape in. The ones who bought made that decision themselves, shilled it to others themselves, and when the price moved against them, pointed the finger at us. Telling other people to buy a token you already hold is also taking liquidity from someone. We did not do that. You did.
Price goes down and suddenly it is a rug. That is not analysis. That is emotion.
Everything we said we would build, we built. The product is live. The registry is real. We are still posting. Still shipping. The Week 2 update: https://t.co/z3ZtllP5XK

No VC. No doxxed front. No borrowed credibility. Just the product, the registry, and the onchain record. If that reads as a scam to you, there is nothing we can say to change your mind, and we are not going to try.

[Open Genome @Open_Genome]

We were here at $5k market cap on the pump(.)fun bonding curve before most of you knew this existed. We are still here now. The people calling this a scam today were not here building the clinical registry, shipping the NFT minting system, writing the API endpoints, seeding 67 herb products into a live marketplace, or getting NCT07578610 registered with https://t.co/k3jXV0MLMd. We were. Every single day since launch.

Let us be clear about something. We never asked anyone to buy. We never ran a campaign telling people to ape in. The ones who bought made that decision themselves, shilled it to others themselves, and when the price moved against them, pointed the finger at us. Telling other people to buy a token you already hold is also taking liquidity from someone. We did not do that. You did.
Price goes down and suddenly it is a rug. That is not analysis. That is emotion.
Everything we said we would build, we built. The product is live. The registry is real. We are still posting. Still shipping. The Week 2 update: https://t.co/z3ZtllP5XK

No VC. No doxxed front. No borrowed credibility. Just the product, the registry, and the onchain record. If that reads as a scam to you, there is nothing we can say to change your mind, and we are not going to try.

[Open Genome @Open_Genome]

We have received many messages asking whether the team is doxxed and whether the price drop reflects something wrong with the project. Here is our full answer. We are an anonymous team. We do not share our identities, and we never have. This space is full of projects that launched with polished social accounts, followed by notable founders, endorsed by recognizable names, with team pages built to look credible. Most of them still rugged. Borrowed credibility turned out to be exactly what the name implies. We built from nothing with no famous co-signs, no purchased reputation, and no manufactured legitimacy. There is no venture capital behind OpenGenome. No institutional round. No vesting schedule. No VC allocation sitting above the market waiting to dump. If the price drops, it is not manipulation. It is panic selling. Pure retail sentiment. There is no coordinated insider exit because there are no insiders in the traditional sense. Anonymity is not a red flag. A doxxed team that exits is far more dangerous than an anonymous team that keeps building.

Medvi just proved what this space is worth: $1.8 billion in telehealth revenue, 2 employees, pure AI. No hospitals, no clinics, no bureaucracy. Just a checkout that works and a product people need. Medical records are moving onchain and Solana is where it is happening. The infrastructure is here. The market is real.

OpenGenome is that model, but for clinical research and biomedical signals. You describe your symptoms, our AI cross-references PubMed and https://t.co/k3jXV0MdWF in real time, pulls the actual studies, and returns a structured biological signal report grounded in peer-reviewed literature. That report gets minted as an NFT on Solana and dual-anchored to OriginTrail's decentralized knowledge graph so the research record is permanent and verifiable. Then you shop. OpenHerb is our marketplace: 67 herbs and supplements, each matched to the biomedical signals in your report. We are a registered observational research study on https://t.co/k3jXV0MdWF under NCT07578610. Status: Recruiting. Full Week 2 update: https://t.co/z3ZtllOy8c

[Open Genome @Open_Genome]

DKG Migration: Base to NeuroWeb

We initially deployed our OriginTrail DKG integration on Base network. After testing, we found that Base does not yet have open public core nodes, meaning knowledge assets published on Base cannot be reliably stored and verified across the network.

We are migrating to NeuroWeb (OriginTrail's native Polkadot parachain, chain ID 2043), which has an active network of core nodes operated by @origin_trail and the community. Every knowledge asset anchored by OpenGenome will be publicly verifiable at https://t.co/mWfxtxDDcC.

We build in public. The full migration process including node configuration, smart contract interactions, and publishing tests is visible in our GitHub at https://t.co/qN9yx411Zw.

Shoutout to the @origin_trail team, for building infrastructure that makes verifiable AI possible.

DKG publishing will go live once the NeuroWeb node is active. All analyses submitted from day one are queued and will be anchored retroactively.

#OriginTrail #DKG #NeuroWeb #BuildInPublic #OpenGenome

[Open Genome @Open_Genome]

Medical records are moving onchain, and Solana is where it's happening.

Medvi just proved the model: $1.8 billion in telehealth revenue, 2 employees, pure AI. No hospitals, no clinics, no bureaucracy. Just a checkout that works and a product people need.
OpenGenome is that, but for clinical herbs and biomedical research.

You describe your symptoms. Our AI cross-references PubMed and https://t.co/k3jXV0MLMd in real time, pulls the actual studies, and returns a structured biological signal report grounded in peer-reviewed literature. That report gets minted as an NFT on Solana, dual-anchored to OriginTrail's decentralized knowledge graph so the research record is permanent and verifiable.

Then you shop. OpenHerb is our marketplace: 67 herbs and supplements, each matched to the biomedical signals in your report. Physical product stays vaulted. Ownership and the clinical record live onchain.

We are a registered observational research study on https://t.co/k3jXV0MLMd under NCT07578610. Sponsor: OpenGenome. Status: Recruiting.

Physical assets stay vaulted. Ownership lives onchain.

https://t.co/v4oiwhvT9z

[Open Genome @Open_Genome]

Medical records are moving onchain, and Solana is where it's happening.

Medvi just proved the model: $1.8 billion in telehealth revenue, 2 employees, pure AI. No hospitals, no clinics, no bureaucracy. Just a checkout that works and a product people need.
OpenGenome is that, but for clinical herbs and biomedical research.

You describe your symptoms. Our AI cross-references PubMed and https://t.co/k3jXV0MLMd in real time, pulls the actual studies, and returns a structured biological signal report grounded in peer-reviewed literature. That report gets minted as an NFT on Solana, dual-anchored to OriginTrail's decentralized knowledge graph so the research record is permanent and verifiable.

Then you shop. OpenHerb is our marketplace: 67 herbs and supplements, each matched to the biomedical signals in your report. Physical product stays vaulted. Ownership and the clinical record live onchain.

We are a registered observational research study on https://t.co/k3jXV0MLMd under NCT07578610. Sponsor: OpenGenome. Status: Recruiting.

Physical assets stay vaulted. Ownership lives onchain.

https://t.co/v4oiwhvT9z

[Open Genome @Open_Genome]

Hey guys, you can check out our OriginTrail DKG integration work right here: https://t.co/KlcqlD0vsN

Here is what we are building. Every time a research report gets minted on OpenGenome, the structured metadata gets published to the OriginTrail Decentralized Knowledge Graph and receives a UAL (Universal Asset Locator) that lives permanently on-chain. This is not just a claim, it is verifiable provenance for every single research output that comes out of our platform, and nobody can tamper with it.

On the infrastructure side, we are running our own full DKG Edge Node on Railway with a stack that includes MySQL, Redis, Blazegraph, and ot-node, all containerized and connected directly to Base mainnet. Our DKG wallet is already live on Base with 150+ TRAC ready to go, and you can track it yourself through our ENS identity at opengenome.base.eth right here: https://t.co/bljIDbf4OK

We are still pushing hard to get everything fully live on time and we know this is ambitious, but we genuinely believe it is worth it because once this is running, every research report on OpenGenome will have a tamper-proof trail that anyone in the world can verify independently.

One more thing we are planning very soon: we will be running a contest to get more people into OpenGenome, introduce $oGNOME to a wider audience, and let people experience firsthand what transparent and verifiable biomedical research actually looks like. Contest details are coming, so stay tuned and keep an eye on this space.
We are building fully in public, the repo is open, and you can see exactly what we are working on at any point.

[Open Genome @Open_Genome]

Many people are confused about what our Base integration actually means, so let us clear this up.

oGNOME is not migrating to Base. What lives on Base is the OriginTrail DKG integration layer, the protocol is native to Base mainnet. Solana is the ownership layer. Base is the knowledge provenance layer. Two chains, two distinct purposes.

[Open Genome @Open_Genome]

OpenGenome Research Dashboard Now Live for Exploration

The OpenGenome research dashboard is now open for early access. You can submit symptoms, generate AI-powered biomedical analyses backed by PubMed and https://t.co/k3jXV0MLMd data, mint your research as a compressed NFT on Solana, and browse the herb recommendation engine.

OriginTrail DKG dual-chain anchoring goes live on Base mainnet within the next 48 hours. Once active, every research NFT minted on this dashboard will be automatically anchored to the OriginTrail Decentralized Knowledge Graph, making each report permanently discoverable, machine-readable, and verifiable across both Solana and Base without any extra steps from you.

In the meantime, the full pipeline is already running in preview mode. You can explore the complete flow end-to-end: from analysis to mint to DKG knowledge asset, the only difference is the blockchain step is currently simulated.

[Open Genome @Open_Genome]

Visit the live research dashboard and explore the full flow yourself from AI biomedical analysis to compressed NFT minting and upcoming OriginTrail DKG anchoring

→ https://t.co/XGDQm3VZxR

[Open Genome @Open_Genome]

OpenGenome Research Dashboard Now Live for Exploration

The OpenGenome research dashboard is now open for early access. You can submit symptoms, generate AI-powered biomedical analyses backed by PubMed and https://t.co/k3jXV0MLMd data, mint your research as a compressed NFT on Solana, and browse the herb recommendation engine.

OriginTrail DKG dual-chain anchoring goes live on Base mainnet within the next 48 hours. Once active, every research NFT minted on this dashboard will be automatically anchored to the OriginTrail Decentralized Knowledge Graph, making each report permanently discoverable, machine-readable, and verifiable across both Solana and Base without any extra steps from you.

In the meantime, the full pipeline is already running in preview mode. You can explore the complete flow end-to-end: from analysis to mint to DKG knowledge asset, the only difference is the blockchain step is currently simulated.

[Open Genome @Open_Genome]

OpenGenome Framework Achieves International ICH GCP Directory ListingWe are pleased to announce that the OpenGenome research framework is now officially indexed in the global https://t.co/u56Ng6Ix3b directory.

What is ICH GCP and Why Does It Matter? The International Council for Harmonisation - Good Clinical Practice (ICH GCP) is the unified global gold standard for designing, conducting, and reporting clinical research. It is jointly maintained by international regulatory bodies (including the US FDA and European EMA) to ensure medical research is both ethically sound and scientifically rigorous.

Key Pillars Achieved under ICH GCP Indexation:
- Absolute Participant Protection: It verifies that our data handling adheres to strict international ethical benchmarks. Your data privacy, anonymity, and rights are legally protected at the highest operational level.
- ⁠Global Scientific Validity: Data gathered under an ICH GCP-tracked registry is universally recognized. This allows global researchers, institutions, and medical journals to trust, verify, and cite OpenGenome’s data outputs.
- ⁠Public Accountability: By maintaining an active, public listing in the ICH GCP directory, our methodologies, safety compliance, and study protocols remain transparently auditable by the global scientific community.

This milestone bridges decentralized open science with traditional clinical compliance, proving that user-driven research can meet the world's highest medical data standards.

���� Verify our official directory entry here: https://t.co/rMn0RvsRi6

#ICHGCP #ClinicalTrials #RegulatoryCompliance

[Open Genome @Open_Genome]

OpenGenome Treasury: Two Cycles Fired

Two treasury cycles have now triggered. 600,000 $oGNOME has been permanently burned. The second cycle completed in full on May 13 - burn executed, 700,000 $oGNOME sold for SOL via Jupiter, and proceeds distributed on-chain.

The staking vault now holds 1.4161 SOL, accumulated entirely from platform mint revenue. 0.8703 SOL remains in the treasury ops wallet covering ongoing protocol costs.

Here is how it works. Every $oGNOME minted flows into the treasury wallet. When the balance hits 1,000,000 $oGNOME, the protocol fires automatically. 30% is burned forever, reducing supply. The remaining 70% is swapped for SOL. Of that SOL, 70% goes into the staking vault and 30% stays for operations. No governance vote, no manual action. It runs on a 10-minute cron with on-chain receipts for every step.

The 89,894 oGNOME currently sitting in the treasury is the start of the third cycle.

This is how OpenGenome stays alive and generates value. Every mint, every herb order, every research NFT - all of it feeds the cycle.

Holders will earn rewards simply by holding $oGNOME. No staking, no lockups. When the distribution mechanism is ready, rewards will flow proportionally to every wallet holding $oGNOME at snapshot time. Hold and earn.

[Open Genome @Open_Genome]

OpenGenome Brings Biomedical Research to the OriginTrail DKG @origin_trail

OpenGenome is an AI-powered clinical research platform that generates biomedical reports backed by real PubMed citations and https://t.co/k3jXV0MLMd data. Each report is minted as an NFT on Solana, giving users verifiable proof of ownership for their research output.

We are now integrating the OriginTrail Decentralized Knowledge Graph as a second anchor for every research record.

When a user mints a research NFT on OpenGenome, the platform automatically publishes the same report to the DKG on Base as a structured knowledge asset. The asset follows the https://t.co/qzDBdWshLJ vocabulary, includes full PubMed citation provenance, and is queryable via SPARQL by any application in the DKG ecosystem.

The result is a dual-anchor research record: a Solana NFT for on-chain ownership, and a DKG knowledge asset for verifiable, tamper-evident, machine-readable knowledge. No research output can be silently edited after publication. Every diagnosis, every citation, every recommendation is permanently anchored on two independent networks.

This integration is being built in the open:
https://t.co/KlcqlD13il

[Open Genome @Open_Genome]

OpenGenome x OriginTrail DKG Integration

We are building the next layer of verifiability into OpenGenome's AI research pipeline.

Every research report generated on the platform will soon be anchored to two independent networks simultaneously. When you mint a report, it gets recorded as a compressed NFT on Solana mainnet as it does today, and at the same time published as a Knowledge Asset on the OriginTrail Decentralized Knowledge Graph via Base blockchain.

This dual-anchoring means your research output is not just a token. It becomes a structured, machine-readable record stored across a decentralized network of nodes, indexed with semantic metadata, and permanently linked to its origin. Any AI system or search engine that understands the knowledge graph can discover and verify it without needing to trust a central server.

@origin_trail DKG uses the Universal Asset Locator standard, giving each research report a globally unique, resolvable identifier that survives chain migrations and platform changes.

The integration is currently in development. The OpenGenome Dashboard will go live with DKG support built in from day one.

Read the full technical breakdown: https://t.co/91I66XjfDZ

[Open Genome @Open_Genome]

OpenGenome x OriginTrail DKG Integration

We are building the next layer of verifiability into OpenGenome's AI research pipeline.

Every research report generated on the platform will soon be anchored to two independent networks simultaneously. When you mint a report, it gets recorded as a compressed NFT on Solana mainnet as it does today, and at the same time published as a Knowledge Asset on the OriginTrail Decentralized Knowledge Graph via Base blockchain.

This dual-anchoring means your research output is not just a token. It becomes a structured, machine-readable record stored across a decentralized network of nodes, indexed with semantic metadata, and permanently linked to its origin. Any AI system or search engine that understands the knowledge graph can discover and verify it without needing to trust a central server.

@origin_trail DKG uses the Universal Asset Locator standard, giving each research report a globally unique, resolvable identifier that survives chain migrations and platform changes.

The integration is currently in development. The OpenGenome Dashboard will go live with DKG support built in from day one.

Read the full technical breakdown: https://t.co/91I66XjfDZ

[Open Genome @Open_Genome]

Coming soon: OpenGenome AI Researcher

OpenGenome is built like an online clinic, except your doctor is powered by real clinical research from PubMed, https://t.co/k3jXV0MLMd, and a growing biomedical corpus. Describe your symptoms, and our AI analyzes thousands of peer-reviewed studies to surface the most likely condition signal, then builds you a complete protocol: evidence-backed lifestyle changes, clinical diet guidance, and targeted herbal supplements, each one traceable to a real PMID.

Every herb recommendation links directly to OpenHerb, our integrated marketplace stocked with 67+ pharmaceutical-grade botanicals. Research it. Buy it. Track it. All in one platform.

[Open Genome @Open_Genome]

From Health Assessment to Your Doorstep: OpenHerb, Early Access, and the Community Shop Vision

We've built the first herb marketplace on Solana that connects directly to OpenGenome's biomedical platform. When your health assessment recommends a herb grounded in PubMed literature, you can find it in the catalog, read the science behind it, and buy it without leaving the platform. Payment is made with $oGNOME on Solana mainnet, every order generates a permanent NFT receipt on-chain, and products ship worldwide from Now Foods.

We're opening access to only 10 buyers in this first phase, not as a promotion, but as a deliberate early evaluation: we want to observe the full order lifecycle, verify the on-chain receipt flow, and ensure the experience holds before opening further. All 10 early buyers get free worldwide shipping included.

This is just the start. The long-term goal is a network of community-operated, OpenGenome-verified shops distributed across regions globally. A user in Berlin sourcing from a verified partner in Germany. A user in New York or Los Angeles ordering from a shop nearby. A user in Italy getting delivery from within Europe. Faster shipping, local presence, and a marketplace that grows with the community rather than around it.

If you want to understand how the full system works from health assessment to your doorstep, and where we're taking this, read the full breakdown at our blog: https://t.co/c90x0D8fRB

[Open Genome @Open_Genome]

OpenHerb is now live.

A herb shop on @Solana, powered by OpenGenome. We are opening early access to the first 10 users as part of our initial service evaluation.

Free worldwide shipping. Products are paid with $oGNOME.

This is our first run. We want to see how the full flow works end to end, from order to delivery. Your participation directly helps us improve the service.

https://t.co/IBzSEjLn1C

[Open Genome @Open_Genome]

Hey everyone, you can check all 67 products we carry and see live order activity here: https://t.co/4SDVZFLeWS

We currently have 3 orders in, all still processing, Ashwagandha shipped to Portugal and Germany, Chamomile to Portugal. Everything is transparent and public, no personal data shown.

7 early access slots still open. If you want in, free worldwide shipping, pay with $oGNOME on Solana, and every order gets a permanent NFT receipt on-chain. We're keeping this first phase to 10 buyers only so we can properly evaluate the full order lifecycle before opening wider.

Grab one of the remaining slots: https://t.co/IBzSEjLn1C

[Open Genome @Open_Genome]

OpenGenome is now officially registered on https://t.co/k3jXV0MLMd.

Study ID: NCT07578610

This marks a significant milestone for the project. Our observational research protocol is now part of the global clinical research registry, verifiable by anyone at https://t.co/jdEArrZopw

OpenGenome uses on-chain genomic analysis to identify early biomedical signals. The registration confirms our commitment to open, transparent, and reproducible research standards.

https://t.co/k3jXV0MLMd is the official US government registry managed by the National Institutes of Health (https://t.co/JkPDrYS0hY) and the FDA where all clinical research must be registered before it can be published in scientific journals. It is the international standard for research transparency.

Its connection to @WHO: The World Health Organization maintains a global registry called ICTRP, the International Clinical Trials Registry Platform (https://t.co/umfNiSPBB9), which aggregates all recognized national registries worldwide. https://t.co/k3jXV0MLMd is one of the primary registries acknowledged by the WHO. Every study registered on https://t.co/k3jXV0MLMd is automatically included in the WHO ICTRP database, though the process runs in batches rather than in real time.

When we will appear on WHO: Typically 2 to 6 weeks after approval on https://t.co/k3jXV0MLMd. We were approved on May 5, so the estimated window is late May to early June 2026.

Why this matters for OpenGenome:

- Global credibility. Anyone in the world can verify that OpenGenome is a legitimate research project, registered in the same system as trials by Pfizer, Eli Lilly, Spectrum Pharmaceuticals, and thousands of other research institutions worldwide.
- @NIH (https://t.co/JkPDrYS0hY) and @WHO recognition immediately strengthens trust with our community and potential research partners.
- Required for publication. The NCT number is a mandatory requirement for submitting research findings to scientific journals.
- Almost no blockchain project holds a https://t.co/k3jXV0MLMd registration. This is a strong differentiator that sets OpenGenome apart.

$oGNOME

[Open Genome @Open_Genome]

OpenHerb is now live.

A herb shop on @Solana, powered by OpenGenome. We are opening early access to the first 10 users as part of our initial service evaluation.

Free worldwide shipping. Products are paid with $oGNOME.

This is our first run. We want to see how the full flow works end to end, from order to delivery. Your participation directly helps us improve the service.

https://t.co/IBzSEjLn1C