Fantastic overview of Skin Bx in Suspected #Vasculitis#IRACON21
👉 HOW (location, depth)
👉 WHEN (timing)
👉 WHY (👀differentials!)
👉 Always do DIF
🎯Granular ICs along BM in CTDs
🎯IgA in HSP/HCUV
🎯IgM in Cryos and RV
🎯 Pauci vs Immune mediated
Among adults with mild to moderate knee osteoarthritis, treatment with platelet-rich plasma vs saline injection did not significantly improve knee pain or slow disease progression https://t.co/uH9VPkActi
If only one test - would do HRCT chest, else with PFT. Also look at risk factors for developing Rapidly Progressive-ILD i.e. age > 50, high ferritin, LDH, and Lymphopenia. Watch for any dyspnea or cough over next few months to a 1 year post dx. Risk of RP-ILD in US 30-50% in MDA5
#SLE and PJP is totally RARE. This study begs against #septra prophylaxis. 3.2 million pts of whom approx 0.1% has #lupus, found by chart audit 4 SLE pts had #pneumocystis#pneumonia of whom 2 had concomitant HIV. So risk of AEs likely outweigh Rx @RheumNow#ACR21 abst#O337
Dr Pillinger on gout: Consider switching atorvastatin ➡️ rosuvastatin (not a CYP3A inhib) in patients on colchicine to reduce risk of toxicity (myopathy)
#ACR21#ACRAmbassador
Good news - a great steroid sparing drug in ANCA vasculitis #avacopan. Bad news - need to mortgage your house and the whole block to get it! #ACR21@RheumNow
#ACR21 Clinical Review of ILD by Dr. Kristin Highland
Approach to SSc-ILD (and often how she approaches CTD-ILD): how to consider incorporation of nintedanib and tocilizumab after focuSSced and SENSCIS Trials ↓
#Scleroderma#RheumTwitter#PulmTwitter
Live from #ACR21:
Learning about osteoarthritis from Dr. Marc Hochberg.
"Don't use the term degenerative joint disease."
-much more involved.
I like this figure of the multiple different phenotypes.
#ACRAmbassador
In ANCA-associated vasculitis, does reverse seroconverting (ANCA+➡️ANCA-) make a difference?
relapse - no
ESRD - no
death - no
Don't measure serial ANCAs for prognosis
(no diff MPO/PR3, RTX/CYC)
target trial emulation @BrighamWomens@MGHrheumatology#ACR21 ABST0419 @RheumNow
Dr Doliner @zach_wallace_md on ILD in AAV. ILD in 13% - of which 76% fibrotic. UIP most common. Most MPO+, but also rarely seen with PR3+. 47% ⬆️ risk of death. Abstr#0430 #ACR21@RheumNow