How much analgesia is needed to manage pain levels in mice after brain surgeries?
A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint):
https://t.co/Ztrjfybfqj
We just released the largest amount of stress profiling data from our (any?) lab so far!
How does the molecular stress response adapt as an acute stressor becomes chronic?
Multiomic profiling in the 🐭 hippocampus, led by @RebeccaWaag and co-last author Pierre-Luc Germain! 💪
🚨Our new #behavior work is out in @Naturemethods! We introduce BehaviorFlow, a pipeline that takes @DeepLabCut tracking and the output of any clustering algorithm to compute the dynamic transitions between behavioral motifs for downstream data analysis 🥳https://t.co/0ned6XaSXm
🔵 I've long been fascinated by the impact of #stress on exploratory rearing in mice. Imagine my excitement when our local collaborator @DeBurdakov approached us with these stunning results: #noradrenaline suppresses rearing through MCH neurons & MCHR1!🤩 https://t.co/ctnTQOwroC
🔵 Noradrenaline directly regulates gene expression in the brain. 8 years in the making, now finally published in @eLife 🥳
During revisions, we added 32 RNAseq samples and a meta-analysis of 71 RNAseqs to rule out major sex differences. #stress
Please RT
https://t.co/80PCFtX44Y
Huge thanks to @Swiss3RCC - our lab's third Swiss 3RCC funding in a row 🥳! Thanks to @osturmscience who leads the 3R efforts in our lab.
This funding is allowing us to radically expand the 3R work in our lab. Stay tuned for the launch of a new 3R-Hub @ETH_en ! 🔥
🚨In our latest preprint🚨 we propose a radical change to the analysis of rodent #behavior in preclinical research.
Featuring @DeepLabCut ♥️
Check out the manuscript and the 🧵👇
https://t.co/7gEbIpRR3a
1st preprint of the Gapplab! Check out our PROTAC tool to mingle with stress hormone receptor signalling A fun collaborative effort by @Carreiralab @BohacekLab @bel_ethz @Meijer_Lab@GermainPl
Lead by stellar students @MGazorpak & Karina Hungentobler https://t.co/JJCwquLQ1g
Serendipity is a huge part of science.
This 🧵 tells the story behind our latest preprint, a journey involving #Stress, #Angiogenesis, #Stroke, #Ischemia, #Cancer and a gene you’ve never heard of!
https://t.co/2UiOTSQSfI…
Kudos to @debocklab who guided most of the work!
The idea for sci-trailers was born at a lab retreat in 2019. The brilliant @osturmscience then started posting these trailers along with new research from our group.
So much fun just putting this list together 😂
Which one is your favorite? The one with the most likes wins!🧵
Our multiomic screen of the changes triggered by acute #stress in the hippocampus is now out in @NatureComm 🥳
Don't miss the wild preprint trailer👇and follow the 🧵 to find out what has changed during the review process. We added (and removed!) a lot! https://t.co/Vfw6U2Hd9B