Bart Williams

[Science Magazine @ScienceMagazine]

"Research is messy. … Trying to protect students from that reality does them a disservice." #TeacherAppreciationWeek https://t.co/xbeaiaHlD4

[Blake Harms @wxblakeharms]

Grand Rapids, Michigan: the city with the worst quality in the nation this morning.

AQI of 217, firmly in the “very unhealthy” quality

[Charlie Johnson @BioMath]

.@Illumina announced that 200 NovaSeqX orders were placed in Q1, and with the competitive pricing offered by labs for X sequencing, it seems a tsunami is about to hit the sequencing core lab market. We are currently experiencing the calm before the storm, with only ripples of what is coming. If we assume that most single NovaSeq facilities will convert to Xs, then market capacity will double. This, coupled with a 44-60% price break with 10B/25B respectively relative to the S4, means that NovaSeq users will have to convert or change brands to remain competitive on price to survive.

In 2020, @Illumina cut Novaseq reagent costs in half, evening the playing field for single NovaSeq labs to be competitive with large outsourcing facilities. This resulted in a massive jump in single NovaSeq labs, and if most of those convert to X, the market capacity will go up by 2.5x. These labs will be looking for ways to use the extra capacity, assuming they were satisfied with one NovaSeq.

Unless demand increases significantly, this year will be tough for labs that cannot afford to buy an X or one of the other short read competitors to reach a competitive price point and keep their customers from looking elsewhere. The last time there was a big buy year was in 2017 with the launch of the NovaSeq. It took a very long time to hit 200 NovaSeq installs, which I used to track on our website. Good luck and hang on for a wild ride.

[Genetic Engineering & Biotechnology News @GENbio]

Drug Corrects Limb Length in Rare Skeletal Syndrome Model

First proof of principle study in mice shows limb length in mouse models of FZD2-associated autosomal dominant #RobinowSyndrome can be corrected using a drug instead of surgery. Read more: https://t.co/3hXdAxIiKp

[Van Andel Institute (VAI) @VAInstitute]

A new laboratory model, developed by VAI and @michiganstateu scientists, allows researchers to see how healthy cells in the lining of the uterus transform into malignant ones, offering new insights into endometrial cancer. Read more: https://t.co/B1mm5gLqkv

[Bart Williams @owen_gr]

Dr. Daisy Fu of the #vai Bioinformatics and Biostatistics core presenting the work from #vanandelinstitute collaborative core group on Spatial omits at #mwacd

[David Cabrera @cabreradm]

Variegated Flycatcher in Michigan! Normally found in South America, there have been less than 10 reports in the US. Super rare find over the weekend, so I made the drive to Port Austin yesterday.#BirdsSeenIn2022 #birding #abarare

[Stephanie Grainger @sgraingerPhD]

I’m super proud of our first pre-print from my lab. Everyone worked really hard getting this together. I think it’s pretty cool. Hopefully some of you do as well! EGFR-initiated endocytosis of Wnt9a and Fzd9b is required for β-catenin signaling https://t.co/ktzAuZjoXB

[Dan Dakich @dandakich]

As we move into the last 4 minutes of the Purdue game REMEMBER…ALL timeouts must be approved by Coach J Howard of Michigan

[Bart Williams @owen_gr]

@TiWindisch DDV is 1 for 14 from inside the arc this year.

[Bart Williams @owen_gr]

@TiWindisch His ballhandling might be worse.

[Bart Williams @owen_gr]

@TiWindisch Hard to do when Connaughton, DDV, and Galloway are 0 for 16.

[Bart Williams @owen_gr]

@TiWindisch Nwora, Hood, and Galloway were a combined 0 for 14 in the first half.

[Bart Williams @owen_gr]

@TomOatesWSJ I think CC is the best manager in baseball, but this seemed like a panic move. I thought that in real time. As others said, there was one out, not two. Other than the grand slam against the Cards, Vogelbach was 4 for 27 as a pinch hitter this year with 1 RBI.

[Bart Williams @owen_gr]

Will the Bucks score in the OT?

[Bart Williams @owen_gr]

@KanePitman And he's the tallest guy on the floor. It's not like it's getting blocked

[Bart Williams @owen_gr]

The Bucks may lose this game because Brook Lopez lost track of the shot clock? After a timeout they took because they had 2.1 seconds left on the shot clock?

[Bart Williams @owen_gr]

@JacobKniffen @TiWindisch @rkattijr Winning these types of games are what makes being a fan great.

Losing these is a gut punch that lasts for months.

Just once, I'd like to be on the right side of one of these as a Bucks fan.

[Bart Williams @owen_gr]

@TiWindisch 2 for 17. He's almost to the John Starks legendary 2 for 18 Game 7 of the 1994 Finals.