I had Claude Code build a very similar setup to analyze my TellMeGen VCF and FastQ files. Initially to pinpoint the variant that causes my hearing loss. It found a new one, not (yet) in ClinVar, but right next to a known pathogenic one. Then I had it re-do all the TellMeGen reports with the latest insights. So much better.
Same. But I accidentally configured a solution: I asked Claude Code to cherry-pick from Garry Tan’s GStack. After that, every response started with an uncomfortable question. Annoyingly so. I kept it that way to prevent more all-nighters.
My other medicine: music (dance) festivals.
For two months now, I'm living in an AI-augmented build stack: Claude Code/Grok/Obsidian and nightly launchd jobs that write iOS apps on their own. 12 apps in a few weeks.
Users besides me: zero.
This week's observation: in 2026, the patent-equivalent is the time between your publication and the next LLM training round. For open-source code that's already under 30 days. After that it's real-time queryable by 100k+ developers.
Moats are shifting away from code, toward:
— distribution (can you reach people?)
— tacit knowledge (can you do something that doesn't fit in a README?)
— persona (are you a brand that isn't replicable?)
I've trained the code muscle. Not the distribution muscle.
Has anyone found a framework for this that works beyond "post 5x a week and hope"?
Huge news. A gene therapy for deafness, targeting a mutation in the OTOF gene, is approved.
Restored hearing in 9 of 12 children, well enough that they could stop using cochlear implants. The treatment will be free in the United States.
Yes, great article. I ran into this article after going ‘founder mode’ on my genetic hearing loss. The Australian guy who figured out cancer treatment for his dog was the inspiration for me. This article filled some gaps in my approach (drug repurposing and compassionate use). See https://t.co/KV5yG55WeO
@Yme Ik ook! Vooral naar twee dingen: 1. Hoeveel irritanter is het monitoren van de bestuurder geworden onder druk van de RDW? 2. Hoe lang moeten HW3 rijders wachten (op die v14 Lite versie)?
@danpeguine@akola77@karpathy This is exactly what I did in my fork today: give the app access to your local Obsidian vault and use CLI to prompt (bonus: you can now use your Claude subscription instead of pay per use API). Having the option to select part of the screen to watch is also a big win.
@FarzaTV@Scobleizer Love the concept. Feel inspired to build a more local version of it. Just checking: your repo is the one with the typo ‘leanring-buddy’?
@Bart_Mol Mooi en herkenbaar. Geeft het belang aan van vriendschappen buiten je ‘bubbel’. Koester die. Het houdt je scherp. En de wereld wordt er beter van.
Don’t miss out! The second Noderunners Conference is happening on September 19th 🔥 Limited tickets available! grab yours now at https://t.co/JEp08EEzZr
@Yme Die gelekte Anthropic code waar de aankomende Claude features in bleken te staan is inderdaad indrukwekkend. En een duidelijke poging om OpenClaw overbodig te maken. Toch hou ik mijn memory/skills etc liever bij mezelf zodat ik makkelijker kan switchen tussen AI partijen.
@karpathy This is awesome! I was struggling with putting over 4000 Apple Notes in Obsidian. Just telling Claude to create a wiki made all the difference. Thank you @karpathy
@NickSpisak_ Does Claude Channels give more updates about what Claude is doing than Dispatch? It’s annoying that Dispatch stays silent until Claude is completely finished with a task.
@Yme Ik koop de boeken wel, maar lees ze lang niet allemaal 😁. Dus redelijk hetzelfde. We riepen het twintig jaar geleden al, maar TV en krant zijn nu toch echt uit het beeld verdwenen.