Onno ter Wisscha

mobile internet guru, innovator, (mobile) telecoms consultant, gadget freak, guitarist

[Onno ter Wisscha @owisscha]

@tomowenmorgan Thanks for the great prompt!

[Onno ter Wisscha @owisscha]

I had Claude Code build a very similar setup to analyze my TellMeGen VCF and FastQ files. Initially to pinpoint the variant that causes my hearing loss. It found a new one, not (yet) in ClinVar, but right next to a known pathogenic one. Then I had it re-do all the TellMeGen reports with the latest insights. So much better.

[Onno ter Wisscha @owisscha]

Same. But I accidentally configured a solution: I asked Claude Code to cherry-pick from Garry Tan’s GStack. After that, every response started with an uncomfortable question. Annoyingly so. I kept it that way to prevent more all-nighters.
My other medicine: music (dance) festivals.

[Onno ter Wisscha @owisscha]

The brain drain explained

[Onno ter Wisscha @owisscha]

@Yme @AnthropicAI Hahaha, inderdaad ongelukkige plaatsing van de ‘subscribe’ link.

[Onno ter Wisscha @owisscha]

For two months now, I'm living in an AI-augmented build stack: Claude Code/Grok/Obsidian and nightly launchd jobs that write iOS apps on their own. 12 apps in a few weeks.

Users besides me: zero.

This week's observation: in 2026, the patent-equivalent is the time between your publication and the next LLM training round. For open-source code that's already under 30 days. After that it's real-time queryable by 100k+ developers.

Moats are shifting away from code, toward:
— distribution (can you reach people?)
— tacit knowledge (can you do something that doesn't fit in a README?)
— persona (are you a brand that isn't replicable?)

I've trained the code muscle. Not the distribution muscle.

Has anyone found a framework for this that works beyond "post 5x a week and hope"?

[Onno ter Wisscha @owisscha]

@Yme Mijn zonnepanelen liggen in de weg. Toch maar een jetpack vanuit de achtertuin.

[Niko McCarty. @NikoMcCarty]

Huge news. A gene therapy for deafness, targeting a mutation in the OTOF gene, is approved.

Restored hearing in 9 of 12 children, well enough that they could stop using cochlear implants. The treatment will be free in the United States.

[Onno ter Wisscha @owisscha]

Yes, great article. I ran into this article after going ‘founder mode’ on my genetic hearing loss. The Australian guy who figured out cancer treatment for his dog was the inspiration for me. This article filled some gaps in my approach (drug repurposing and compassionate use). See https://t.co/KV5yG55WeO

[Onno ter Wisscha @owisscha]

@Yme Ik ook! Vooral naar twee dingen: 1. Hoeveel irritanter is het monitoren van de bestuurder geworden onder druk van de RDW? 2. Hoe lang moeten HW3 rijders wachten (op die v14 Lite versie)?

[Onno ter Wisscha @owisscha]

@danpeguine @akola77 @karpathy Yes it does. The app ‘just’ needs some extra permissions.

[Onno ter Wisscha @owisscha]

@danpeguine @akola77 @karpathy This is exactly what I did in my fork today: give the app access to your local Obsidian vault and use CLI to prompt (bonus: you can now use your Claude subscription instead of pay per use API). Having the option to select part of the screen to watch is also a big win.

[Onno ter Wisscha @owisscha]

@Yme Zullen we een keer horror en hallelujah verhalen uitwisselen?

[Onno ter Wisscha @owisscha]

@FarzaTV @Scobleizer Love the concept. Feel inspired to build a more local version of it. Just checking: your repo is the one with the typo ‘leanring-buddy’?

[Onno ter Wisscha @owisscha]

@Bart_Mol Mooi en herkenbaar. Geeft het belang aan van vriendschappen buiten je ‘bubbel’. Koester die. Het houdt je scherp. En de wereld wordt er beter van.

[Noderunners.Conf @NoderunnersNET]

Don’t miss out! The second Noderunners Conference is happening on September 19th 🔥 Limited tickets available! grab yours now at https://t.co/JEp08EEzZr

[Onno ter Wisscha @owisscha]

@Yme Die gelekte Anthropic code waar de aankomende Claude features in bleken te staan is inderdaad indrukwekkend. En een duidelijke poging om OpenClaw overbodig te maken. Toch hou ik mijn memory/skills etc liever bij mezelf zodat ik makkelijker kan switchen tussen AI partijen.

[Onno ter Wisscha @owisscha]

@karpathy This is awesome! I was struggling with putting over 4000 Apple Notes in Obsidian. Just telling Claude to create a wiki made all the difference. Thank you @karpathy

[Onno ter Wisscha @owisscha]

@NickSpisak_ Does Claude Channels give more updates about what Claude is doing than Dispatch? It’s annoying that Dispatch stays silent until Claude is completely finished with a task.

[Onno ter Wisscha @owisscha]

@Yme Ik koop de boeken wel, maar lees ze lang niet allemaal 😁. Dus redelijk hetzelfde. We riepen het twintig jaar geleden al, maar TV en krant zijn nu toch echt uit het beeld verdwenen.