Boaz Palterer

MD PhD, Allergy and Immunology Fellow @BostonChildrens @harvardmed | Ex-Clinical Immunologist @AOUCareggi | Exploring #Autoimmunity and #Immunodeficiency

[Boaz Palterer @palterer]

@allisonoconn HLH

[Boaz Palterer @palterer]

@P_McCulloughMD @McCulloughFund VAERS data is unverified and uncontrolled. This is analysis makes no sense. It's like using a survey to evaluate survey participation. Garbage in, garbage out.

[Boaz Palterer @palterer]

@seagertp @KnowledgeAcqui1 By the way, this conversation is looking only at direct mortality, and ignoring morbidity and indirect mortality.

Measles wrecks havock in the immune system.
https://t.co/RAEXG2qO8L

[Boaz Palterer @palterer]

@DrJesseMorse The death rate for measles in 1962 was about 1 in 500,000 from the total population.... which is between 1 in 1,000 and 1 and 10,000 cases

[Boaz Palterer @palterer]

@seagertp @KnowledgeAcqui1 The passage from hundreds of deaths per year (1960) to single digits (1980), which is driven by the decrease in the number of cases, and it's not "a continuation of the pre vax trend".
Without the vaccine we would still have hundreds of deaths per year.

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp The purple rectangle was driven by better life conditions and medical advancements. From thousands to hundreds of deaths.

The vaccine caused an incidence plummet, which tackled the "intrinsic" mortality (e.g encephalitis cases).
From hundreds to single digit deaths

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp Not questioning that.
Ultimately regardless of whether it was "vast" or "slight", we have the hard boundary of the deaths that shows how incredibly effective the vaccine is

[Boaz Palterer @palterer]

@seagertp @KnowledgeAcqui1 In the 50' early 60’ you had a few hundreds deaths per year, 70' in the tens, by the 80' and up to now we are in the single digit...

[Boaz Palterer @palterer]

@seagertp @KnowledgeAcqui1 The point is that before the vax in the US you had a few hundred deaths per year, after the vaccine those plummeted to close to 0

Other example UK data https://t.co/EsOPrfl5Pe

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp I can't speak to the accuracy of this specific data in the US in 60', but the incidence and fatality rates are consistent across multiple years and locations, including places where reporting is for sure more accurate

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp It would be a circular reference if it was derived from a single experience... But we have the same numbers from multiple countries and multiple years, including recently, when reporting is very strict given how rare measles is now

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp As you pointed out mortality is very well documented and it imposes bounds to what is the incidence.
Regarding reporting, measles is different then the flu... It was possible to make a clinical diagnosis and you get it only once.

[Boaz Palterer @palterer]

@KnowledgeAcqui1 @seagertp Cases might have been slightly underestimated, but given the known bounds of mortality for the infection, the error is likely small.

By the way, this is only direct mortality, indirect morbidity and mortality is missed in this reports.

[Boaz Palterer @palterer]

@seagertp Another way to look at it 1 death/500.000 population, equals 400 deaths for a population of 200 million.

[Boaz Palterer @palterer]

@seagertp Its in the legend of figure 1 "cases and death for 100.000 population"... Look at figure 2 in the same paper, it reports the fatality rate, and it's perfectly in line with the CDC data

[Boaz Palterer @palterer]

@ALNeehus @NatImmunol Terrific work, congratulations to all

[Boaz Palterer @palterer]

@JRosain @casanova_lab That's so disappointing... Now I have to recheck all my "transient thrombocytopenias" for WAS 😂

[Journal of Experimental Medicine @JExpMed]

Mizuno lab @HiroshimaUnivEn show monoallelic mutations in MMD2 disturb fMLP-induced activation of Ras/ERK signaling & underlie the impairment of neutrophil chemotaxis which leads to the development of the autosomal dominant form of aggressive periodontitis https://t.co/0ZxWi9kdo4