Pascal Devant

Postdoc @Marsonlab @GladstoneInst @UCSF | PhD in Virology with @jkagan1 @harvardmed | Interest in Mechanistic Immunology, Cell Biology, Synthetic Biology

[Pascal Devant @pascal_devant]

Ever wondered how inflammatory caspases recognize IL-1 cytokines for cleavage?
Read more in our new paper, a collaboration between @jkagan1 and @WuLabHarvard labs out today @Nature

See🧵👇
1/
@harvardmed @BostonChildrens @VirologyHarvard @HarvardMicro
https://t.co/B7ae8BjK6K

[Ivan Zanoni @Lo_Zanzi]

More than thrilled to share that I’ve been promoted to full (tenured) Professor @harvardmed @Harvard. This only happened because of the hard work of many people, but I want to dedicate this promotion to my grandmas, Nonna Maria & Nonna Vevè. A #FirstGen thread 🧵 1/x

[nature @Nature]

Nature research paper: Caspase 5c amplifies Wnt via APC cleavage to promote intestinal homeostasis

https://t.co/7Xr1tQF5k8

[Murad Mamedov @MuradRMamedov]

New Lab Alert! I am thrilled to share that next month I am starting my new role as an Assistant Professor at The Wistar Institute. I am extremely excited to work with fantastic new colleagues at Wistar and collaborate with researchers across UPenn.

[Prof. Hao Wu @WuLabHarvard]

Excited to share an amazing video on the NLRP3 inflammasome pathway generated by talented Ann from the Iwasa lab @janetiwasa @Ann_HuiLiu. It shows the real cryo-EM structures of the pathway from #NLRP3, #ASC, #caspase-1, #GSDMD, #IL-1b, to #NINJ1. #cryoem @LeXiao17 Enjoy

[Brandon Chen, PhD @BrandonTWChen]

Excited to share that my PhD work on ER mito contact sites is finally out at @MolecularCell! Big shout out to @stark2_d to take this across the finish line, and @YatrikShahLab and @LyssiotisLab for their guidance as always!

[Pascal Devant @pascal_devant]

Tachykinin signaling defines distinct populations of glia in the enteric nervous system.
Excellent work by Anu Muppirala, Meena Rao and team @BostonChildrens @harvardmed @PiN_Harvard published today in @NeuroCellPress

https://t.co/4x5U2xTDkN

[Ronghui (Ron) Zhu @RonZhu2015]

Together with Emma Dann, we are thrilled to present a massive new Perturb-seq atlas of 22M primary CD4+ T cells, from 4 donors, across 3 timepoints – the result of a decade-long collaboration between the Marson (@MarsonLab) and Pritchard (@jkpritch) labs.
🧵👇

[@AbrahamLabHMS @abrahamlabhms]

We are excited to share our new @CellCellPress paper revealing mechanisms of action of promising drugs against the helicase–primase of herpes simplex virus 1 (HSV-1) 🤩@HarvardMicro https://t.co/gI9eIKPeEL

[Waggoner Lab @LabWaggoner]

@biorxivpreprint Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells
https://t.co/ZKuus86EZr
@HyuncheolJung @pascal_devant @Marsonlab
@GladstoneInst @UCSF @jccarnevale

[Stacie Dodgson, PhD @StacieDodgson]

Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant

[Pascal Devant @pascal_devant]

Excited to share the first Co-First author manuscript from my postdoc in the Marson lab @GladstoneInst Great collaboration with @HyuncheolJung from @jccarnevale lab @UCSF on CRISPR editing and screening in primary human myeloid cells!
See tweetorial below!
https://t.co/EVVBBGPwND

[Stacie Dodgson, PhD @StacieDodgson]

Another exciting paper from @GladstoneInst Genomic Immunology - check out our latest preprint on myeloid cell editing: Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells, led by @HyuncheolJung and @pascal_devant

[bioRxiv Immunology @biorxiv_immuno]

Virus-like particles enable targeted gene engineering and pooled CRISPR screening in primary human myeloid cells https://t.co/AXrWic6D14 #biorxiv_immuno

[Dave Boucher @dave_boucher]

New preprint from the lab from PhD student Seb Grant. Started as a summer side project and developed into an exciting story.
Evolutionary convergence of a Pyroptosis-Apoptosis crosstalk drives non-canonical inflammasome signalling. https://t.co/lIjMX6F4mz

[Pascal Devant @pascal_devant]

@dave_boucher Congrats on the cool findings!

[Cornelius Taabazuing @taabaman]

Check out our latest work led by two talented postdocs, Madhura and Chris @TheBourneImmuno. We find that CASP4/5 can cleave and activate CASP3/7, acting as initiators of both pyroptosis and apoptosis. Notably, both are needed for full pathogen defense! https://t.co/L4LkUm29jl

[Jonathan Kagan @jkagan1]

meta-PAMPs: A new class of immunostimulatory molecules that control the ability of bacterial factors to operate as PAMPs. Jordan Jastrab reveals that wall teichoic acid (WTA) is a key regulator of inflammasomes and interferons during infection.
https://t.co/daLucqLeEi

[Ivan Zanoni @Lo_Zanzi]

#InterferonPower! Thrilled for our latest work @CellCellPress! With @dfrboehmer, we dug into tons of papers & created what we hope will be a go-to resource for immunologists & non-immunologist about type I, II, III (& IV😉) #interferons! Free link 👉 https://t.co/gYwGir0npB

[Dave Boucher @dave_boucher]

New review from our lab. Kudos to PhD student @SebGrant346534. 10 things you wish you knew about inflammatory caspases: a holistic review of their biochemistry, activation, and signalling - Journal of Biological Chemistry https://t.co/9zrVa1sU0T

[Jonathan Kagan @jkagan1]

Everything you wanted to know about oxidized lipids & immunity, in one review. We explain how oxidized lipids impact inflammation, dendritic cells, anti-tumor immunity and more.
Kudos to Joon Choi for his exceptional work.
@harvardmed @BostonChildrens

https://t.co/8J68zbKONa

[Shiyu Xia @ShiyuXia]

In January 2026, I will be joining Berkeley @UCBerkeley as an Assistant Professor in the Department of Chemical and Biomolecular Engineering, College of Chemistry @UCB_Chemistry, with exciting connections with world-class communities including the Lawrence Berkeley National Laboratory @BerkeleyLab and the California Institute for Quantitative Biosciences @QB3Berkeley.

Incredibly grateful to all the mentors (especially @ElowitzLab and @WuLabHarvard), colleagues, friends, and family who made this next chapter possible. ❤️🙏

Research directions and student/postdoc opportunities coming soon. Stay tuned! 👀