Stephanie Holdener

Attending Pathologist MD🔬 Animal lover🐈🐕 Video gamer ( @pathsmalls ). Former BCM AP/CP Resident, 2020 MDACC Cytopath Fellow, & 2021 UNM Hemepath Fellow.

[Siba El Hussein, MD @SibaElHussein]

Tricky case of Cyclin-D1-positive neoplasm➡️

Patient presented with "pancytopenia, rule out MDS"

Flow cytometry of a limited marrow aspirate revealed a CD20-positive Kappa restricted population that appeared to be negative for CD19 expression #hemepath #lymsm #mmsm #MedTwitter

[Siba El Hussein, MD @SibaElHussein]

An underrecognized variant of nodal marginal zone lymphoma (NMZL) is the "eosinophil-rich variant", which is a unique subset not mentioned/emphasized by the current WHO/ICC

A knowledge of this variant of NMZL can prevent it from being misdiagnosed as PTCL (particularly AITL) which seems to be not an uncommon mistake

More on this & illustrative picture below of this variant from➡️
https://t.co/FTUiB5bXLq

#hemepath #lymsm #pathtwitter #surgpath #medtwitter #bmtsm

[Charlie Herndon @DrCycloPath]

Desert Island Dermatopathology:

You get 1 IHC to dx this small blue cell tumor

Which will it be??

Leukocyte common antigen (LCA)
S100
CK20
Thyroid Transcription Factor-1 (TTF-1)
#DermPath #BSTPath #PathResidents #PathMatch2024 #Pathology #PathTwitter
📝https://t.co/8IWeuUwHYS

[Stephanie Holdener @path_smalls]

🤢

[Pathology Society of Philadelphia @philly_path]

Hi #PathTwitter! We have 9 year old girl presented with fever, muscle pain after consumed pork, chicken sandwich and potatoes. The following is the muscle biopsy of the child. What is the most likely etiologic agent for the children's illness? #Microbiology #Pathology

[Siba El Hussein, MD @SibaElHussein]

Nodal TFH cell lymphoma, follicular-type➡️ If a lymph node looks like it's involved by NLPHL or FL, but the aberrant population has a T-cell phenotype, think about
this entity #hemepath #lymsm #PathTwitter #medtwitter

[Stephanie Holdener @path_smalls]

@4theLoveofPath @PeymanDin83 @RiveraRolonMD I love it! 😍

[Sanam Loghavi, MD صنم لغوی 🔬🧬 @sanamloghavi]

59 y/o man with leukocytosis (WBC: 265K)
You can order one test…. Which would you choose based on this morphology. Poll below or comment if feeling brave. #hemepath

[Siba El Hussein, MD @SibaElHussein]

Drug Reaction With Eosinophilia and Systemic Symptoms Syndrome (DRESS) involvig LN with AITL-like morphology:

🩸Dense infiltrate of polymorphic lymphocytes
🩸Preserved overall architecture: Adequate B & T-cell compartments (sign of benignancy)

#hemepath #lymsm #pathtwitter

[Gloria Sura, MD @Gloria_SuraMD]

Pap test cytology reveals squamous cells that have multinucleation, nuclear margination, and nuclear molding. What is the diagnosis? Answer: https://t.co/fch8lt2bYe #CytoPath #Cytology #Cytopathology #PathArt #IDTwitter #MedTwitter

[Sanam Loghavi, MD صنم لغوی 🔬🧬 @sanamloghavi]

Takes 100 mg of #Zinc 3 times a day 😒
#hemepath PSA: STOP self-prescribing excessive zinc people, it depletes your #copper and makes your bone marrow very angry 😡

[Stephanie Holdener @path_smalls]

@ErnieKeeblerr 🙏 RIP

[Stephanie Holdener @path_smalls]

@ErnieKeeblerr Why are they not in Dark Mode? My eyes burn

[Stephanie Holdener @path_smalls]

@DoctorVig @OSUMedPedsRes Hey now, only 2! LOL Pathology takes time 🤣

[Stephanie Holdener @path_smalls]

@AaronGoodman33 Beautiful example!

[Stephanie Holdener @path_smalls]

@AaronGoodman33 Important point Dr. Foucar always stressed was to look at feathered edge and side of smears, especially in cases of complete marrow failure. Blasts can be sneaky!

[Mehrnoosh Tashakori, MD, PhD @TashakoriM]

Minnesotan elderly with 5 days of fever, headache, myalgia, low WBC (low absolute lymph), low Plt; increased LFT; any takers #pathtwitter ? 🔬🩸 #hemepath

[Stephanie Holdener @path_smalls]

@BloomquistSuzy Congratulations!!! 👏

[Stephanie Holdener @path_smalls]

@DanBabuMD @hemepathguy Still in shock from ours! 🥴

[The New York Times @nytimes]

Sales of plastic water bottles and other single-use plastic products will be phased out at national parks and on public lands in the U.S. over the next decade, the Interior Department said this week. https://t.co/eTXKDNVl4Z