connie shen

drug developer @genentech | prev phd @mcgillu & @mandllab | immunology • mechanobiology • cell migration 👁🧫👁🔬

[Waggoner Lab @LabWaggoner]

T cells must preserve their structural integrity while migrating through dense environments. A central actin pool under confinement balances forward propulsion with shape integrity to protect nucleus from DNA damage @SciImmunology @peepingcells @mandllab
https://t.co/xY59SJAYSC

[connie shen @peepingcells]

@LammerdingLab @MandlLab Thank you!

[Mandl Lab @MandlLab]

Huge congratulations to Dr. Connie Shen @peepingcells on delivering an outstanding thesis defense! Our fourth Mandl PhD will soon be leaving the nest, trading cold Montréal for sunny California! ☀️All the best!

[Mandl Lab @MandlLab]

Check out our recent publication in collaboration with the Khadra Lab at @mcgillu - where computational modelling 🖥️ and experimental immunology 🔬join forces to study the role of T cell diversity and antigen binding strength on chronic infection clearance! Find out more 👇

[orthweinlab @orthweinlab1]

10 years after I helped generating an Otub1 knock-out mouse model in the @durocherlab, now Dr. @MingyiLuo cracked it down... With the immense help of the @MandlLab, he identified the γ-Subunit Gng2 as a novel substrate of Otub1 in splenic B cells.
https://t.co/hKMi00UbCa

[Mandl Lab @MandlLab]

Wondering what we can learn from the T cell receptor beta sequence about the self-reactivity of a T cell? check out our paper in Cell Systems where we used machine learning to ask this very question👇: https://t.co/r5wIUCuyxF

[connie shen @peepingcells]

@tlngy @MandlLab We don’t have migration data without the pillars, but in the wider 6um sections we don’t see the speed differences!

[connie shen @peepingcells]

@tlngy Thank you! We love a good imaging session 😎

[connie shen @peepingcells]

Why do neutrophils have a uniquely lobulated nucleus?

We used primary human neutrophils with differentially segmented nuclei to examine whether one role is in facilitating migration through tight spaces. Read about it here!

[J Cell Science @J_Cell_Sci]

Connie Shen @peepingcells, @MandlLab @mcgillu, @Vrisekoop @UMCUtrecht and colleagues discover that nuclear segmentation allows neutrophils to migrate faster in confined spaces.
Highlight: https://t.co/pYxP4oEofJ
Report: https://t.co/RvCDk25qPQ
#OpenAccess #ReadandPublish

[connie shen @peepingcells]

@MandlLab

[connie shen @peepingcells]

@caitlinsciences Thank you my dearest science mother 🥹

[Mandl Lab @MandlLab]

Why do neutrophils have multi-lobed nuclei? 🧐

Does this enable their rapid migration through tight spaces? 🏃‍♀️💨

In this study, we sought to answer this question experimentally 🔬

Here is what we found 👇

[FocalPlane @focalplane_jcs]

Our aMAZ(E)ing #MidweekMovie comes from @peepingcells, @MandlLab, @Vrisekoop and colleagues. They discover that neutrophils with segmented nuclei have a speed advantage when migrating through confinement spaces.
📖@J_Cell_Sci: https://t.co/E3JghLGJSY

[connie shen @peepingcells]

@jpostat Merci papa couldn’t have done it without you 🥹🥹🥹

[connie shen @peepingcells]

@MikeGoldVan Thank you! 😀

[connie shen @peepingcells]

Please appreciate the brilliant @J_Cell_Sci research highlight title: Knobbly neutrophil nuclei navigate narrow niches 😍

[connie shen @peepingcells]

@jpostat Oh yes this should be a fun journal club! 👏

[connie shen @peepingcells]

Submitted! Thank you @CdnImmunol for the travel award to attend @iuis_online congress in Cape Town!

Incredibly excited to visit South Africa and talk immunology with everyone 👩🏻‍🔬

[International Union of Immunological Societies @iuis_online]

🚨LAST CHANCE TO SUBMIT YOUR ABSTRACT!🚨

There is less than 1 weeks left to submit abstracts for #IUIS2023 in Cape Town! Don't miss this opportunity to share your research at the largest immunology conference in the world.

Submit at https://t.co/TmiSZIXdvj before May 2nd.

[timisstuck @timisstuck]

After they learned what everyone studied, two patrons at this little gay bar in Galveston TX started chanting “Cell migration! Cell migration

Surest sign of a successful @GordonConf 😃

[Mandl Lab @MandlLab]

Connie & Jeremy enjoying #celllavie2 https://t.co/q1RzeEkePk in Paris showing off our newest movies of human neutrophils and T cell crowds.