Great to see N17350 move into first-in-human evaluation. This is the kind of milestone that reflects both the strength of the science and the enormous amount of operational work behind the scenes, from translational research, manufacturing and clinical execution.
Onchilles has dosed the first patient in a Phase 1/2 trial of N17350, our lead tumor-directed ELANE pathway therapeutic, to evaluate its potential to selectively kill cancer cells in advanced solid tumors while preserving and not suppressing immune cells.
https://t.co/FruOaetRdX
New NEU-002 data presented at #AACR26 support a systemic approach built on the ELANE pathway, intended to kill tumor cells while sparing immune cells. Program leads showed anti-tumor activity after both IV and IP administration.
https://t.co/bOBw1xLcPb
Excited to share new data at AACR 2026 on NEU-002, demonstrating anti-tumor activity via systemic delivery as we extend our ELANE pathway approach into systemic solid tumor targeting.
It is rare to see a cytotoxic approach that also preserves immune function. From a development and partnering perspective, that combination opens meaningful strategic pathways.
Court and Lev explain the science and strategy well in this episode. Worth a listen.
For decades, weโve accepted a tradeoff: kill the tumor or preserve the immune system.
Not anymore.
On this podcast, our co-founders discuss how our therapeutics targeting the ELANE pathway can pair selective cancer killing with immune activation.
https://t.co/AxryqxI7Pw
Onchilles will present and participate in 1-on-1 meetings at the Oppenheimer 36th Annual Healthcare Life Sciences Conference.
For details and scheduling information, see the release: https://t.co/Rn6bPNI2aQ
IND clearance for N17350! The ELANE pathway represents a cancer-selective, immune-activating approach with broad potential across solid tumors, and weโre excited to begin exploring how this differentiated biology could translate into meaningful clinical outcomes.
Onchilles Pharma Announces IND Clearance for N17350, Advancing the First Next-Generation Cytotoxic Therapeutic Leveraging the #ELANE Pathway into the Clinic
Read the release for more: https://t.co/PvEhE9TlvN
The #AACR25 data highlight that N17350 continues to show strong and selective anti-tumor activity while avoiding immune toxicityโa key challenge with traditional cytotoxic therapies. Get in touch should you want to learn more!
New data presented at #AACR25 show our lead therapeutic candidate, N17350, delivers potent, selective tumor killing while preserving immune functionโwith the potential to overcome chemotherapy-resistant disease.
Read the release: https://t.co/KNY6i49ZMr
#ELANEpathway#ELANE
We are excited to present new preclinical data at #AACR25 for N17350, our lead ELANE-based drug candidate, which has the potential to become a major new treatment modality for cancer. If youโd like to learn more, send me a DM.
We're unveiling at #AACR25 new preclinical data for the next-generation cytotoxic therapeutic, N17350, which leverages the #ELANE pathway and has the potential to selectively kill #cancer and stimulate the immune system.
https://t.co/QtHuPKnpm4
Excited to welcome @Lev Becker as CSO and @Emily Roberts-Thomson as SVP of Development Operations at @Onchilles Pharma! Together, weโre poised to advance our pan-cancer therapeutics targeting the #ELANE pathway into clinical trials.
Thrilled to welcome Dr. Lev Becker as CSO and Emily Roberts-Thomson as SVP of Development Operations! Their leadership will drive our pan-cancer therapeutics targeting the #ELANE pathway into clinical trials.
Learn more: https://t.co/VDqs1gzsHg
#immunotherapy#cancer
The highlights of the data presented at #SITC24 from our IV-delivered NEU-002 program targeting the #ELANE pathway:
โก๏ธ๐๐ป๐ต๐ฎ๐ป๐ฐ๐ฒ๐ฑ ๐ฆ๐ฝ๐ฒ๐ฐ๐ถ๐ณ๐ถ๐ฐ๐ถ๐๐ ๐ฎ๐ป๐ฑ ๐๐ฐ๐๐ถ๐๐ถ๐๐
โก๏ธ๐ฆ๐ฒ๐น๐ฒ๐ฐ๐๐ถ๐๐ฒ ๐๐ฎ๐ป๐ฐ๐ฒ๐ฟ ๐๐ฒ๐น๐น ๐๐ถ๐น๐น๐ถ๐ป๐ด
โก๏ธ๐๐๐ฟ๐ฎ๐ฏ๐น๐ฒ ๐ฅ๐ฒ๏ฟฝ๏ฟฝ๐ฝ๐ผ๐ป๐๐ฒ๐
Today we announced new preclinical data presented at #SITC24 for the NEU-002 program โ targeting the #ELANE pathway through systemic delivery, for potent and selective cancer killing with the potential to treat a wide range of cancers.
https://t.co/LYyemHGq4l
Today we announced new preclinical data presented at #SITC24 for the NEU-002 program โ targeting the #ELANE pathway through systemic delivery, for potent and selective cancer killing with the potential to treat a wide range of cancers.
https://t.co/LYyemHGq4l
We are excited to present new data at #SITC24 for NEU-002, leveraging our novel MoA, the ELANE pathway. Our first-in-class oncology programs have the potential to become a major new treatment modality for a wide range of cancer types. If youโd like to learn more, send me a DM.
Today we announced the presentation of new preclinical data at #SITC24 for our NEU-002 program, leveraging the #ELANE pathway, a novel innate immune MOA for potent and selective cancer killing with the potential to treat a wide range of cancers.
https://t.co/evmkolaWz5
Excellent Q&A with @Lev Becker sharing more about the #AACR24 buzz around our lead drug candidates with their novel mechanism of action that @Onchilles Pharma is leveraging to treat a wide range of cancer types.
Our cofounder @LevBecker chatted with @Pharmashot about the excitement around our #AACR24 data, the difference between N17350 and N17465, and details for our upcoming #clinicaltrial.
Read the Q&A here: https://t.co/MfsZdq9S1s
Our cofounder @LevBecker chatted with @Pharmashot about the excitement around our #AACR24 data, the difference between N17350 and N17465, and details for our upcoming #clinicaltrial.
Read the Q&A here: https://t.co/MfsZdq9S1s
Today in #SanDiego we gave a talk titled, โN17350: a novel therapeutic modality that selectively kills #cancer cells and induces potent anti-tumor immunity to eradicate tumors.โ
If you missed it, read our recent data release: https://t.co/JjUwJffIOq
Weโve had an exceptional response to the data we presented at #AACR24 and our clinical trial plans. If youโd like to learn more, DM me to set up a meeting.
Our cofounders chatted with @SDbusiness about our recent #AACR24 data showing our lead drug candidate works across many #cancer types to kill tumor cells but leave healthy cells alone โ as well as how our upcoming #clinicaltrial could quickly yield data.
https://t.co/JaHVAZzStO
We are excited to present our preclinical data at #AACR24 for N17465 and N17350, first-in-class biologic therapeutics, harnessing a novel innate immune MoA, with the potential to become a major new treatment modality for a wide range of cancer types.
We're unveiling at #AACR24 preclinical data on systemically delivered N17465 in an oral presentation and new preclinical data for tumor-directed N17350. Both leverage a novel innate immune MOA and have the potential to treat a wide range of cancers.
https://t.co/QpZMBjv93a
N17350โs is truly a unique cancer drug. While immunotherapies and targeted therapies can deliver one or two of these attributes, our belief is that all three are needed to lead to global and durable tumor responses.
In this Q&A with @DrugTargetRev, our cofounder Dr. Lev Becker shares more about how N17350 selectively and potently kills cancer cells irrespective of their genetics and anatomical origin, mobilizes adaptive immunity, and avoids resistance mechanisms.
https://t.co/olBshgdumy
We will be presenting at #ImmunoSeries on our lead drug candidate, N17350, which is an emerging therapeutic modality that selectively kills any #cancer cells and stimulates anti-tumor immunity.
For the full @ImmunoOncConf agenda visit: https://t.co/nHw6Qc9LDW
We are excited to present our preclinical data at #SITC23 for N17350, a first-in-class biologic therapeutic, inspired by the immunobiology of neutrophils, with the potential to become a major new treatment modality for a wide range of cancer types. If want to learn more, DM me!
We will be presenting at #SITC23 our latest data on our lead drug candidate, N17350, showing a unique combination of potent and selective #cancer killing activity to eradicate #tumors independent of genetics or anatomical origin.
https://t.co/pvUMdERFk7