Peter Crane

CEO, Founder, Entelo Bio. AI for Human Physical Resilience

[Jake P. Taylor-King @wildtypehuman]

Two-year anniversary scTrends update

CC @scTrends_update @AdamCribbs @peterkcrane

[Peter Crane @peterkcrane]

Great piece from @danny__kruger here especially around the concept of a "Patriotic Compact". If the UK can nurture the conditions that enable founders to start, scale and sustain their companies in the UK, then many founders, I believe, will give back by choice, creating positive ecosystem effects that lead to inflows of capital, expertise and wider societal benefits.

[Danny Kruger @danny__kruger]

My essay 'Britain and AI: the Patriotic Compact', published today - https://t.co/oYzaDNk2hc

Summary:
AI is not a sector. It is a change in the conditions of national life.

AI could have the social and strategic effects of the printing press, nuclear energy, and the internet - all at the same time, concentrated into less than a decade.

Each of these had enormous benefits for humanity - but huge side-effects too. The printing press drove the Reformation and all its positive social consequences in terms of personal liberty, economic development and national sovereignty. But the Reformation prompted the Thirty Years War, devastating the continent.

Seeing the upheaval that printing threatened for an ordered society, Europe’s neighbour the Ottoman Empire took a different approach: they banned it. That didn’t work out well for the Ottomans. They ultimately lost the race of civilisation, and declined and declined till they were finally snuffed out in 1918.

Our challenge is to avoid the fate of the Ottomans, but to avoid the Thirty Years War as well. Because our Thirty Years War may be a lot shorter, and a lot more terminal.

AI could transform human health and deliver the productivity our economy has lacked for 20 years - with huge benefits for us all. To realise this we need more AI, not less - but AI managed well. The only way out is through.

At the moment we are at the mercy of the USA. It could be worse - China would be worse - but we urgently need to set a course for soveriegnty. That doesn't mean autarky; it just means more capability and more opportunity to shape our own future.

Reform UK offers the 'patriotic compact' to AI entrepreneurs: we will help you build the data centres and connect to the grid; for your part you must keep your firms here, pay your taxes here, create jobs here.

Jobs are crucial - Britain must stop destroying work and start helping businesses grow; and use tax and welfare to help people adapt to the jobs of the new economy.

And most of all - we must make AI serve humanity not subjugate it. The Pope is right: AI does 'not know from within what love, work, friendship or responsibility mean.' We must focus ourselves, and focus AI, on nurturing human relationships - or will be, like the builders of Babel, ‘lords of towers destined for ruin’.

Fundamentally Britain cannot slow down AI. What Britain, and countries like it, can do is develop AI at the pace of innovation but in the direction of human flourishing.

[Peter Crane @peterkcrane]

@NateHindman @drrichjlaw Just like every synbio company starts off trying to “change the world” and eventually becomes a drug CRO or CDMO

[Peter Crane @peterkcrane]

You can just do things…..just not in the British State it seems….

[Tom Jones @93vintagejones]

The Chinese built the Huajing bridge, the world's tallest, for about £215 m.

[Peter Crane @peterkcrane]

@jontycorrin You’ll have to explain to them who Demis is….

[Peter Crane @peterkcrane]

This is the most underrated tweet I’ve seen and needs more attention. Not pro or anti China but is downstream risk on commercial launch being diligence or priced?

[Bharath T. @PreemptDisease]

There is a major IP diligence issue hiding in China biotech asset acquisitions.

Some enabling technologies may be patented in the U.S. but practiced abroad where enforcement is weaker or impractical.

Under 35 USC 271(g), importing, selling or using in the U.S. a product made by a U.S.-patented process can create infringement exposure. 35 USC 295 can also shift the burden under defined conditions.

This is no longer just a 'China cost advantage' issue. It is an IP provenance issue for acquirers: what platform, process or enabling technology was actually used to generate the asset?

[Quanquan Gu @QuanquanGu]

After solving protein structure prediction, the next frontier is designing therapeutics.

Foundation models has transformed language.
They will transform biology next.

AI for drug discovery is no longer just a niche application, it’s becoming a frontier AI problem.

[Peter Ottsjö @peterottsjo]

Listen to Jake. Stop moaning. Build.

[Jake Wintermute 🧬/acc @SynBio1]

I knew as soon as midjourney announced that CT scanner I was going to be treated to every medical imaging expert on earth posting every possible technical limitation of CT scanning that might make it not work

Never change biotech

[Peter Crane @peterkcrane]

@rheum_ai So I agree 1-2 OOM underestimation easy, but ppl inside medical/biology often convince themselves it’s 7-8 OOM as rationale for not doing / having a swing

[Peter Crane @peterkcrane]

We need more of this and kudos to @midjourney

[Midjourney @midjourney]

A technical dive inside our new "Midjourney Scanner"

[Peter Crane @peterkcrane]

@Aria_Churchill @SaraNayeem posts some really useful stuff!

[Tim Peterson @timrpeterson]

@PalmerLuckey @anish_koka And current biotech. Moar.

[Peter Crane @peterkcrane]

Now waiting for the #UK to counter this by announcing a £10M funding call.... of course, gated by a 10,000-word grant application and a 6-month+ wait until decisions communicated....

[Peter H. Diamandis, MD @PeterDiamandis]

Russia just committed $26 billion to anti-aging research and made longevity a national priority. Welcome to the longevity arms race!

[Peter Crane @peterkcrane]

@alex_karnal is spot on. Latent demand is there in chronic and lifestyle-associated diseases, across continents. Now on us in the bio industry to get safe, simple and accessible medications out quickly to satisfy this desire.

[Alex Karnal @alex_karnal]

For years, the assumption has been that people struggle to prioritize their health, that life gets in the way.

The data is starting to tell a different story.

In my conversation on @InvestLikeBest earlier this year, we discussed what the early launch data for oral Wegovy was showing: people are more motivated to take ownership of their health than many assume.

New reporting from @Bloomberg offers another data point worth paying attention to.

More than 10,000 people in the UK have already joined a waiting list for @novonordisk's oral Wegovy ahead of its expected approval.

Roughly three-quarters of those individuals have never previously taken a weight-loss injection.

This is more than simply existing GLP-1 users switching from a weekly injection to a daily pill. It suggests a large cohort of people who were previously sitting on the sidelines are now willing to act.

When effective interventions become easier to access, use, and incorporate into everyday life, people respond.

That lesson extends well beyond GLP-1s.

Whether it's diagnostics, continuous monitoring, preventive medicines, or other components of the broader health stack, we should not underestimate people's desire to invest in their long-term health when practical and affordable options are available.

https://t.co/VT6snMA0e0

[Peter Crane @peterkcrane]

@bryan_johnson @bryan_johnson Given that GLP-1a medications are also vasodilatory, which is suggested as one of their indirect but beneficial adaptive effects on skeletal muscle, I'd be super interested to see if there's any stacking seen between these 2 common medications.

[Peter Crane @peterkcrane]

Must be all the Reta in the air / water……

[Lukas (computer)🔺 @SCHIZO_FREQ]

Something about being in the city of san francisco makes me find the concept of sex absolutely disgusting

If you forced me to live here long enough I would find a way to reproduce through cloning

[Mgoes (bio/acc 🤖💉) @m_goes_distance]

are you paying attention chad?

the anti-aging and human enhancement arms race just went geopolitical

- Russia committed $26B. Putin made longevity a Kremlin priority. organ printing, genetics, cryotherapy.
- China published a 5-year national biotech plan. gene therapy, BCIs, AI drug discovery. genuine human firsts, not me-too drugs.
- UAE launched a national longevity program backed by sovereign wealth. zero taxes. fastest clinical trial approvals in the world.
- Singapore is funding longevity research at the state level and recruiting the world's best biotech founders.

and the private sector is not waiting

- Life Biosciences just injected the first reverse-aging drug into a human
- NewLimit raised $435M from Peter Thiel's Founders Fund. Brian Armstrong's bet on age reprogramming is moving from lab to clinic.
- Retro Biosciences raised $1.8B. Sam Altman's bet on adding 10 healthy years to human lifespan is scaling.
- Isomorphic Labs raised $2.1B. Demis Hassabis betting AI designs drugs better than humans.
- Neuralink has 21 implants in humans. Merge Labs launched with $252M. the BCI race is real.
- Altos Labs. $3B from Bezos. cellular rejuvenation. the largest single longevity round ever.

every major power and every serious founder on earth is pointing at the same problem

the race has begun

bio/acc

[Peter Crane @peterkcrane]

@katclone @mattgdean03 Would argue strongly that IP is largely irrelevant in 2026 :) — https://t.co/cN78BiHz4b

[Peter Crane @peterkcrane]

@shelbynewsad @CompoundVC @Basecamp_Res @NOETIK_ai @recursus Nooooo.... arrive back into SF from BIO day after :S! Line-up looks great!