Peter Ly

Genome Integrity Lab | Assistant Professor @CRI_UTSW @UTSWMedCenter. We study how chromosomes segregate, break, and rearrange in cancer genomes.

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Peter Ly @PeterLyLab]

The Ly Lab @CRI_UTSW is recruiting two #postdocs to study intercellular DNA transfer. Join us to tackle fundamental questions at the intersection of genome instability, cell-cell communication, and cancer evolution. Please share! 🙏

Full posting: https://t.co/INoSPaqx95

[Discover Magazine @DiscoverMag]

Learn how DNA can be exchanged between two cells that connect by forming nanotubes, and find out why this is crucial for cancer research. https://t.co/TnR95PRDuO

[Peter Ly @PeterLyLab]

Proud milestone for our lab. Congrats to our first two graduate students, Lizz Maurais, PhD, and Justin Engel, PhD! @UTSWGradSchool

We also celebrated Lizz’s last day as she moves on to an exciting new adventure @biogen. Good luck Lizz!

[James Dewar @JamesMDewar]

🧬 ⛓️‍💥 Our paper is now out in @NatureSMB! We examined the fate of replication forks that collapse at single-strand DNA breaks (SSBs) in vertebrates 🐸, comparing the consequences of collapse at single vs convergent forks. https://t.co/fBccyccPUU

[Science News @ScienceNews]

Until now, no one had seen DNA voyaging between human cells along intercellular highways called tunneling nanotubes.
https://t.co/SWBYnx7yRI

[Zha Lab @zha_lab]

Are you ready for the Summer? Social DNAing is! Check out the 2026 Summer line-up! Please note one schedule change on June 4th, 2026. Please RT! Sign up at https://t.co/XaGM9LsycS

[Cell @CellCellPress]

Now online! Genome instability triggers intercellular DNA transfer between human cells https://t.co/36msLGRyJh

[Floris Barthel @florisbarthel]

Telomere crisis is an engine of genomic instability, driving the structural evolution of cancer genomes. Our new preprint finds this damage isn't random: it converges on the nucleolus and the chromosomes that build it. 🧵
https://t.co/oKnZv6hgo6

[Peter Ly @PeterLyLab]

Had a fun conversation with @ScienceNews about our recent findings. Thanks for covering our work!

[Science News @ScienceNews]

Like prisoners tunneling out of jail, damaged DNA travels via tubelike structures between neighboring cells.
https://t.co/SWBYnx7yRI

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

ONLINE NOW in @CellCellPress: @PeterLyLab has discovered large pieces of DNA can transfer directly between human cells & that DNA can persist, change how the recipient cell functions. Read more about this #relentlessdiscovery ⬇️ https://t.co/cmNRqAfXaR

[Children’s Research Institute at UT Southwestern @CRI_UTSW]

#relentlessdiscovery from @PeterLyLab

[Peter Ly @PeterLyLab]

Congrats to grad student Lizz Maurais, who drove this project with relentless resilience alongside a remarkable team of lab members and collaborators! (7/7)

@CRI_UTSW @UTSWMedCenter @UTSWGradSchool

[Peter Ly @PeterLyLab]

Excited to share our latest paper, out today @CellCellPress. We found that large pieces of the human genome can transfer between cells upon direct contact, endowing recipient cells with heritable phenotypic changes. (1/7)

https://t.co/SbshGhofN0

[Peter Ly @PeterLyLab]

Many questions remain. We now aim to define the prevalence, mechanisms, and biological impact of intercellular DNA transfer across physiological and disease contexts.

🚨 We are recruiting #postdocs to lead these efforts – please reach out if interested! (6/7)

@UTSWPostdocs

[Joe Nassour @NassourJoe]

Our review is now live @TrendsCellBio. We discuss how the DNA repair pathways c-NHEJ, MMEJ, and HR intersect at mammalian telomeres and the consequences for chromosomal instability. https://t.co/TTstou5YZW

[Kazuhiro Maeshima @kazu_maeshima]

Our new preprint! 🧬 https://t.co/tnSERwnIWm
@NagataY51868 et al. combined single-nucleosome imaging with Fucci probes to follow local chromatin behavior during interphase. Local nucleosome motion stays nearly constant from G1 to G2, except in early G1. Thanks to all coauthors!