BREAKING: SERENA-4 is negative. Similar to giredestrant, camizestrant did not improve outcomes vs AI when combined to CDK4/6i in the 1L setting. Its role remains confined to pts with ESR1 mutations, which seems to be the sweet spot for oral SERDs in MBC. https://t.co/d4g58bmmzM
One week to #ESMO25. An unprecedented ESMO conference. Seven positive press releases, anticipating the expansion of T-DXd to the curative setting, two Trop2 ADCs reaching first-line mTNBC, 2 novel ET-based combos, adjuvant CDK4/6i improving OS. See you in Berlin! #ESMOAmbassadors
The honesty, thoughtfulness, and wit of @ChrisSweens1
Phase 3 trials of Immunotherapy in Prostate Cancer --
A Case Study of "Failed All-Comer Strategy"
⚡️8 negative trials
💰 >$700 million USD
👨🦰 7,305 patients
#ESMO24@urotoday
Ribociclib is now approved by the FDA for the adjuvant treatment of patients with stage II and III ER+/HER2- breast cancer based on the NATALEE trial, showing 5% iDFS benefit at 4 years with the addition of ribo to adjuvant endocrine treatment
Incredibly proud of Peter de Gooyer from my group presenting NICHE-3 on neoadj nivo/rela in dMMR colon cancer at #ESMO24 with concomitant publication in @NatureMedicine ➡️ open access https://t.co/rditsr605Q @NKI_nl#ESMOAmbassadors
#Ribociclib now @US_FDA ✅ for adj early stage HR+ breast cancer. Recent #ESMO24#NATALEE: Stg IIA - III, 400mg (3wks on/1wk off) for 3yrs
- Improved iDFS w/Ribo at 4yrs (HR: 0.715)
- Improvement seen in all subgroups including N0. OS immature
#bcsm#OncTwitter@OncoAlert
#ESMO2024 Total neoadjuvant treatment (TNT) with non-operative management (NOM) for proficient mismatch repair locally advanced rectal cancer (pMMR LARC): First results of NO-CUT trial by Alessio Amatu
- 97% dfs , 85% organ preservation achieved
Presidential for @Silke_Gillessen@Uromigos#ESMO2024 Radium223 + enza vs enza alone shows a PFS and OS advantage in metastatic CRPC. PEACE3 is an investigator trial and rejuvenates radium-223 in prostate cancer. 0.69 HR for PFS and OS !!!
The 1st disitimab Vedotin (HER-2 MMAE ADC) & pembro showing 1st line response rates of 75% in HER 1-3+ UC. Toxicity profile looks distinct from EV (fatigue>skin). There is a global randomised phase 3 of DV & pembro vs standard chemotherapy. #ESMO24@DrRosenbergMSK@MattGalsky
Nectin-4 is the target for Enfortumab Vedotin and is widely expressed in UC (median 275/300) . EV302 is 1st randomised trial to explore its relationship with response. IHC results show no clear relationship between Nectin-4 and outcome (RR,PFS,OS) or PD-L1 #ESMO2024
Two years later, on Sept 15th #ESMO24, I will present the long awaited 3-year DFS data for NICHE-2 ‼️
But that’s not all…exciting🩸ctDNA dynamics included. See you there! @myESMO@NKI_nl