Pete Wongkongkathep

Reseacher at Chulalongkorn University, Thailand. Cancer immunotherapy, Mass spectrometry geek, Bioinformatician, Peptide chemist, and Landscape Photographer

[Eric Topol @EricTopol]

AlphaFold: predicting the protein structure from amino acid sequence for >200 million proteins (awarded @NobelPrize)

Today
Alpha Genome Atlas: predicting the molecular impact of all 9 billion variants of the human genome

https://t.co/DkEtZofJ8s

[Anshul Kundaje @anshulkundaje]

Very excited to announce ENCODE GRAMMAR (Genomic Regulatory Atlas of sequence Models, Motifs, Annotations & Rules): 3,865 experiment-specific deep learning model sets and sequence annotations for decoding human regulatory DNA. 1/

[Jensen Huang @JensenHuang]

For my first post, I’m sharing a letter @NVIDIA signed on why open models matter.

AI will transform every industry, power every company, and be built by every country.

Open models strengthen safety and cybersecurity, accelerate innovation and diffusion, and enable sovereignty.

The world needs both frontier closed models and frontier open models.

https://t.co/AUKzoQ5Ikb

[Pete Wongkongkathep @piriyawk]

Our neoantigen paper is finally out!

[Clinical Cancer Research @CCR_AACR]

Now online: The Phase Ib IMPACT Trial of Intramuscular Personalized Neoantigen Synthetic Long Peptide Vaccines in Patients with Advanced Melanoma and Renal Cell Carcinoma https://t.co/UdUM3t1ie7

[Oscar Tahuahua @drtahuahua]

🚨 1 in 7 NSCLC patients on first-line immunotherapy will develop severe toxicity

And it begins early
➡️14% severe irAEs
➡️~70% within the first 3 months
➡️Median onset 1.4 months

Risk ↑
ChT + ICI (HR 2.35)
Pre-existing autoimmune disease (HR 1.25)
Longer diagnosis to treatment interval (HR 1.50)

Risk ↓
Atezolizumab vs pembrolizumab (HR 0.75)
Nivolumab (HR 0.91)

Lung, blood, GI, these lead (not rare, not late, and not random)

The highest risk patients are already defined before treatment and show it within weeks
https://t.co/BArHqRsOcd @OncoAlert

[Eric Topol @EricTopol]

What's the meaning of the glucose spikes after eating?
A new @NatureMedicine study finds people have different food triggers and some connect with insulin resistance, along with ways to mitigate spikes
https://t.co/MIcS5hS5nU

[Vorachat @vorachatMD]

ลัทธิ anti-vax และ anti ยาปัจจุบัน อ้างว่า
- ��่อมะเร็ง
- หมอได้%จากบริษัทยา

Fact
- ยาสมุนไพรไม่เคยมีpaperถึงมะเร็ง
- ตัวเองขายสมุนไพร

คนเชื่อเยอะมากโดยใช้ตรรกะ
มีคนพูดแบบนี้เยอะ = ต้องจริง
ด้วย algorithm ที่ส่งคอนเท้นซ้ำๆให้คนดู

หรือกำลังกลับสู่ยุคป่วยแล้วกินใบไม้ต้ม 🤔

[Marios Georgakis @MariosGeorgakis]

Time for the weekly read list on genetics, multiomics, & precision medicine🧵

1⃣Drivers of immune cell-specific gene expression in an Asian population

Across 619 Asian donors, integration of scRNAseq with genetic data enabled the discovery of molecular properties of immune cells while offering a great new resource of single-cell eQTLs❗️

🔗https://t.co/8Mon6J8o8B

[Yansheng Liu @Yanshen73854711]

Thrilled to share our latest work published in @CellCellPress: Turnover Atlas of Proteome and Phosphoproteome Across Mouse Tissues and Brain Regions! https://t.co/LrnmFtK24I @Yanshen73854711 @JunminPengLab @euforna @YaleMed @YalePharm @CancerYale @HUPO #Proteomics #TeamMassSpec

[Cell @CellCellPress]

Now online! Asian diversity in human immune cells https://t.co/kbvjKAIn4y

[Nature Reviews Genetics @NatureRevGenet]

New online! Beyond the black box with biologically informed neural networks https://t.co/prbcPOr63Y

[The Nobel Prize @NobelPrize]

"People considered me unsuccessful."

Katalin Karikó met with biomedicine student Emanuelle Tavares to talk about life and science. Our medicine laureate explains that, despite being terminated from her position, she felt successful as she was always learning in her lab.

Watch the full conversation: https://t.co/MEd8gfttDQ

#WomeninScience

[The Nobel Prize @NobelPrize]

Consider this advice from 2023 medicine laureate Katalin Karikó on managing stress.

Do you have any tips for stress management?

[Itai Yanai @ItaiYanai]

Published today! We found that cancer cells adapting to drug treatments don't simply switch from a sensitive to resistant state; instead there's a ‘resistance continuum’ of resistant phenotypes with epigenetically reprogrammed states. 🧵⬇️
https://t.co/Jgx79K3i3a @Gustavo_SFranca

[Olivier Elemento @ElementoLab]

Wow! GLP-1 receptor agonists now linked to a substantial reduction in incidence for 10 types of cancers, in patients with Type 2 Diabetes !https://t.co/xUiXl0wUAy

[Fan Liu lab @theliulab]

A fly stuck at the spray tip?? You must be kidding me…

[Patrick Hsu @pdhsu]

What if we could universally recombine, insert, delete, or invert any two pieces of DNA?

In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design

[James Lucas @JamesLucasIT]

Thread of before and after photos 🧵

1. Chichen Itza in 1892 and now

[OpenAI @OpenAI]

Say hello to GPT-4o, our new flagship model which can reason across audio, vision, and text in real time: https://t.co/MYHZB79UqN

Text and image input rolling out today in API and ChatGPT with voice and video in the coming weeks.

[Google DeepMind @GoogleDeepMind]

Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬

Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 https://t.co/gjw6Ip4F2M