Pluchino lab - Regenerative Neuroimmunology

Developing experimental molecular medicines for chronic inflammatory diseases of the brain. 🇬🇧🇺🇸🇮🇹🇫🇷🇿🇦🇭🇰🇺🇦

🦋 Bluesky @pluchinolab.bsky.social

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Honoured and humbled to be elected a Fellow of the @acmedsci
Looking at the remarkable colleagues I join as Fellows, I hope to be worthy of this recognition. Dedicated to advancing stem cell tech for research and cure of neuroinflammatory diseases @CentreMyelin @Cambridge_Uni

[Academy of Medical Sciences @acmedsci]

Our new cohort spans an impressive range of sectors and disciplines:

🔬 Industry including pharma, biotechnology and drug discovery
💡 Traditionally under-represented fields such as speech and language therapy, medical ethics, traumatic brain injury and AI in healthcare

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Circulating cell type senescence signatures track distinct dimensions of health status and trajectories in human longitudinal cohorts https://t.co/GJsdmHYi2V

[ECTRIMS @ECTRIMS]

🚀 New podcast series: 𝐌𝐒 𝐑𝐞𝐬𝐞𝐚𝐫𝐜𝐡 𝐁𝐫𝐢𝐞𝐟𝐬

Welcome to our new ECTRIMS podcast series delivering an expert guided tour of important new studies in multiple sclerosis research.

In each episode, leading MS experts will take a small number of recently published studies and go beyond the headline findings – exploring what the research shows and how it may influence clinical practice and future discovery.

In our first inaugural episode, host Prof. Alan J Thompson of UCL and guest host Prof. Olga Ciccarelli of UCL discuss two important new publications:

📄 Paramagnetic Rim Lesions and Development of Clinical MS in Radiologically Isolated Syndrome (@JAMANeuro, 2026)

📄 Machine learning-based combination of the central vein sign, cortical lesions and paramagnetic rim lesions (@braincomms, 2026)

𝐓𝐨𝐩𝐢𝐜𝐬 𝐢𝐧𝐜𝐥𝐮𝐝𝐞:

· Radiologically isolated syndrome (RIS)

· Paramagnetic rim lesions (PRLs)

· Central vein sign (CVS)

· Machine learning and AI-supported diagnosis

· The future of MRI biomarkers in MS

🎧 𝐋𝐢𝐬𝐭𝐞𝐧 𝐧𝐨𝐰:
𝐀𝐩𝐩𝐥𝐞: https://t.co/UVbvdw3UQi
𝐒𝐩𝐨𝐭𝐢𝐟𝐲: https://t.co/h01GfZBQlQ
𝐖𝐞𝐛𝐬𝐢𝐭𝐞: https://t.co/Xinocy8NC3

Timothy Reynold Lim et al. from St. Michael's Hospital, University of Toronto. Maxence Wynen et al. from UCLouvain - Université catholique de Louvain.

#MultipleSclerosis #MSResearch #Neurology #Neuroimaging #MRI #ArtificialIntelligence #ECTRIMS #MSResearchBriefs

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

The neuroimmune system and cognition https://t.co/FpWe6LrNst

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Advances in Multiple Sclerosis https://t.co/Ib14uwhBXk

[Nature Immunology @NatImmunol]

Read our special focus on Neuroimmune connections:

https://t.co/MXY9NKJG8E

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Epigenetic mechanisms of inflammatory memory in the central nervous system https://t.co/mxFgYeVJgr

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Blood-based circular RNAs for early diagnosis of Alzheimer’s disease https://t.co/Gh4wC9Q44l

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Meta-analysis of DNA methylation aging signatures in 17 human tissues https://t.co/OrFhTg9Hva

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Functional neuronal circuitry and oscillatory dynamics in human brain organoids https://t.co/On7SloVVZZ

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data

(helping with particle-based simulations of mitochondria, motors, and microtubule networks)

https://t.co/tk74AbYE05

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Mitochondrial quality control in human ageing and longevity

https://t.co/CTLBg1UdKB

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Arc mediates intercellular tau transmission via extracellular vesicles: Cell https://t.co/xWKCHYJQKc

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Genotoxicity profiling reveals distinct platform-and cell type-specific effects in therapeutic gene editing for genetic hyperinflammation https://t.co/EHW5Ef0JFD

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Spreading α-synuclein rewires organelle communication and impairs neuron–astrocyte mitochondrial quality control | bioRxiv https://t.co/7Dj8NnJCSQ

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

How to give a bad talk | Nature Reviews Cancer https://t.co/lrRTxAkYH7

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

@Ella_Maru 👏🏻👏🏻👏🏻

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

The aging genome exhibits organized vulnerability to somatic mutations | bioRxiv https://t.co/mrcyproiT1

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Aging: from cellular mechanisms to organismal physiology - PLOS Collections https://t.co/PKlukpXVEe

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

The elephant in the room: impact factor | Development | The Company of Biologists https://t.co/jqif0GvVED

[Pluchino lab - Regenerative Neuroimmunology @Pluchinolab]

Brain age gap in multiple sclerosis: associated with disability but independent of serum biomarkers https://t.co/wdmmKFlAe2