Pere Puigserver B

[Journal of Clinical Investigation @jclinicalinvest]

Weekend Read: 🧵 1/3 | JNK inhibition rescues beta cells from ER stress-induced apoptosis https://t.co/q63VnkJ6TR
The findings of Laura C. Alonso & team @WeillCornell highlight the potential for targeting JNK/p53 signaling in the unfolded protein response to preserve insulin secretion in #Diabetes.
In the featured images, TUNEL and insulin colocalization reveals that JNK inhibition (1/2) rescued beta cell death in cultured islets compared with DMSO treatment (2/2).
@the_asci

[Journal of Clinical Investigation @jclinicalinvest]

@WeillCornell 🧵 2/3 | JNK and p53 cause human and mouse pancreatic beta cell death during excessive unfolded protein response: https://t.co/LlAlIvFX0X

[Journal of Clinical Investigation @jclinicalinvest]

@WeillCornell 🧵 3/3 | See the Commentary by Jonathan M. Palozzi & Pere Puigserver: https://t.co/li9RNxbk03

[Journal of Clinical Investigation @jclinicalinvest]

@WeillCornell See the Commentary by Jonathan M. Palozzi & Pere Puigserver: https://t.co/li9RNxbk03

[Journal of Clinical Investigation @jclinicalinvest]

JNK inhibition rescues beta cells from ER stress-induced apoptosis https://t.co/q63VnkJ6TR

The findings of Laura C. Alonso & team @WeillCornell highlight the potential for targeting JNK/p53 signaling in the unfolded protein response to preserve insulin secretion in #Diabetes.

In the featured images, TUNEL and insulin colocalization reveals that JNK inhibition (1/2) rescued beta cell death in cultured islets compared with DMSO treatment (2/2).
@the_asci

[Journal of Clinical Investigation @jclinicalinvest]

Diabetic and ER-stressed pancreatic islet beta cells are in need of some JNK removal: https://t.co/li9RNxbk03

Jonathan M. Palozzi & Pere Puigserver @danafarber provide a Commentary on Sharma et al.: https://t.co/LlAlIvFX0X
#Diabetes

[Puigserver Lab @puigserver_lab]

New commentary from Jonathan and Pere in the JCI on diabetic and ER stress pancreatic islet beta cells related to an article from Alonso's lab on this topic.
https://t.co/t3nqEoW4li

[Molecular Cell @MolecularCell]

If you can only attend a handful of meetings next year, @CellSymposia #CSMito2026 should be a priority. It offers a comprehensive, top-to-bottom perspective on mitochondria, and brings together a diverse group of scientists from across the field.
Visit: https://t.co/TUlucMVPlu

[Nature Cardiovascular Research @NatureCVR]

❤️Our October issue is out❤️Read about the RNA editing enzyme ADAR1 regulating atherosclerosis progression, PGC-1α and cardiac adaptation to exercise training, the role of LYVE1-macrophages in heart regeneration and peripheral artery disease, and more.

https://t.co/6IDTiQSHE7

[Sumeet Khetarpal @SumeetKhetarpal]

The Khetarpal lab at UVA is seeking a research associate (postdoc)! Please see the posting and reach out with any questions! https://t.co/GNNQldP6uo

[Puigserver Lab @puigserver_lab]

Check out the latest paper from the Spiegelman lab that we collaboratored on looking into the role of cardiac PGC1a in adaptations to exercise. Congrats to Sumeet and all the other co-authors!

[Sumeet Khetarpal @SumeetKhetarpal]

Happy to share our manuscript published today on regulation of cardiac adaptation to exercise training by PGC-1α and GDF15 in @NatureCVR! https://t.co/gb1KSEchWM

[Spiegelman Lab @LabSpiegelman]

Cardiac PGC1a is required for adaptations of the heart to exercise (in mice). A wonderful collaboration with the lab of Tony Rosenzweig. Sumeet is off to start his won lab at UVa (congrats!) https://t.co/gR7B2QuLIt

[CIB Margarita Salas (CSIC) @CIB_CSIC]

#CIBseminars

Mechanisms of mitochondrial adaptive respiration

Pedro Latorre Muro, Dana-Farber Cancer Institute/Harvard Medical School, Boston, MA (USA)

📆July 17
⏰15pm

Online seminar. Registration required 🔗https://t.co/sOM9HFzQvJ

[Puigserver Lab @puigserver_lab]

New preview just published in Molecular Cell! We highlight exciting work by Chen et al. identifying an arginine sensing axis mediated by BAG2 and SAMD4B that promotes survival under arginine deficiency.

https://t.co/m71gz29mUv

[Jason Liang @jiaxinliang7]

Thrilled to share that I’ll be starting my new position as a tenure-track assistant professor at the @OSU Comprehensive Cancer Center on July 1st! And to continue my journey to conquer cancer through the lens of metabolism and immunity.

[Jason Liang @jiaxinliang7]

Thanks from my deep heart to @puigserver_lab @PpuigserverB, Kai Wucherpfennig, Hans Widlund, Jean Zhao, and everyone at @DFCI_CancerBio and @harvardmed for your mentorship and support. Excited for what’s ahead!

[Eduardo_Balsa @BalsaEduard]

Job offer! We are looking for a motivated postdoctoral researcher with expertise in cancer metabolism/immunology to investigate metabolic heterogeneity as a driver of cancer metastasis. @CBM_CSIC_UAM @criscancer #cancermetabolism #immunometabolism

[Puigserver Lab @puigserver_lab]

Matthew Ravichandran ’23 Wins ASA Early Career Scientist Award for Bridging Faith and Science  https://t.co/7bf254Wguo via @@gordoncollege
Congratulations Matthew!

[Pere Puigserver B @PpuigserverB]

Frontiers | Study insights in the role of PGC-1α in neurological diseases: mechanisms and therapeutic potential https://t.co/JzLe8oXIIs