Pradeepa Pushparaj

Mom, Scientist. Vaccine/infection immunology, Forever fascinated by antibodies. views are my own.

[Pradeepa Pushparaj @Pradee05]

Check out our paper showing how IGHV1-69 polymorphisms can affect SARS-CoV-2 antibody functions. Amazing supervision from @NillaKH Martin Corcoran.
Great collaboration with @BenjMurrell @DannySheward @das_hrishikesh1 @BMartinHallberg out @ImmunityCP

https://t.co/VCcIBkONPu

[Pradeepa Pushparaj @Pradee05]

Antibodies with shared structure and CDR H3 sequence features from 3 recent publications take center stage in our Trends in Microbiology Spotlight.

A classic example of how mAbs help guide vaccine design.

https://t.co/yfMyb8JlTT

[Pradeepa Pushparaj @Pradee05]

@vinodscaria As a Tamil vaccinologist, I’m proud 🥹

[Pradeepa Pushparaj @Pradee05]

@supriyasahuias @MoHFW_INDIA @TNDPHPM You are one of the few well uniformed politicians. Great job TN for getting the facts right ❤️

[Pradeepa Pushparaj @Pradee05]

@Nature Oh, the paywall? :/ science has enough roadblocks, doesn’t it?

[Michael 英泉 Eisen @mbeisen]

It's an absolute scandal and tragedy that India is forced to spend $250m/year to provide access to the latest science to its people. A complete and total failure of global science leadership and of science writ large.

[Pradeepa Pushparaj @Pradee05]

@camillaengblom @Qirongliiin @thrane_kim Very cool and so thorough 😊

[Pradeepa Pushparaj @Pradee05]

@mbeisen Visit Ulriksdal Slottsträdgården https://t.co/3Fc5kifHi3

[Pradeepa Pushparaj @Pradee05]

By reintroducing somatic hypermutations into a germline-reverted mAb, we delineate the role of affinity maturation in the development of cross-neutralization in a public class of antibodies.

As always, antibodies are fascinating.

Thanks to @NillaKH and everyone involved 🤍

[Martin Hällberg @BMartinHallberg]

Finally out! Structural insights into antibody affinity-maturation. Thanks to @DannySheward @Pradee05 @das_hrishikesh1 @BenjMurrell @mcinerney_gerry
@Jan_Albert_ @_LeoHanke @AllieGreaney @jbloom_lab @NillaKH https://t.co/AnBb3DGMHb

[Pradeepa Pushparaj @Pradee05]

@Jeff_Mold @PGTimmune IgDiscover’s clonoquery module

[Pradeepa Pushparaj @Pradee05]

@camillaengblom @thrane_kim @Qirongliiin @Jeff_Mold @FrisenJonas @joalunatkthse @karolinskainst @scilifelab @KTHuniversity How cool! 😎 congratulations 🍾

[Cell Reports @CellReports]

Stringent and complex sequence constraints of an IGHV1-69 broadly neutralizing antibody to influenza HA stem https://t.co/USBgNAy3uG

[Pradeepa Pushparaj @Pradee05]

Very well deserved! :)

[The Nobel Prize @NobelPrize]

BREAKING NEWS
The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.

[Pradeepa Pushparaj @Pradee05]

@sebbeols @ImmunityCP Congratulations Sebastian🍾 🎉

[Pradeepa Pushparaj @Pradee05]

@ejvillablanca @SmedSorensenLab @camillaengblom @scilifelab @karolinskainst Congratulations 🎉🍾

[Ben Murrell @BenjMurrell]

Real-time data update: we've got our first BA.2.86 (see red arrow) neutralization results. Short 🧵with much credit to @DannySheward and the rest of the team.

[Pradeepa Pushparaj @Pradee05]

@BenjMurrell @DannySheward Amazing work as always

[Yunlong Richard Cao @yunlong_cao]

Sharing some new experimental data on BA.2.86:
1) BA.2.86 is antigenically distinct compared to XBB.1.5.
2) BA.2.86 can significantly escape XBB-infection/vaccination induced antibodies.
3) However, the infectivity of BA.2.86 may be much lower than XBB.1.5 and EG.5. (1/n)

[bioRxiv Immunology @biorxiv_immuno]

Antibody gene features associated with binding and functional activity in vaccine-derived human mAbs targeting malaria parasites https://t.co/oX6krrsBqX #biorxiv_immuno

[Pradeepa Pushparaj @Pradee05]

@PhDVoice @PostdocVoice Give it a couple years 😄 or three

[Pradeepa Pushparaj @Pradee05]

@vinodscaria @bani_jolly @the_hindu Could you please share?