Ronald A. Primas,MD,FACP,FACPM

Integrative board certified internist/concierge #doctor available 24/7 for housecalls, preventive, urgent & routine care, #longevity,#healthspan #Biohacker.Dad.

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@TulsiGabbard Glad to hear the surgery was successful. Recovery is often the hardest part, but it sounds like Abraham is on the right path. Wishing him strength, comfort, and a full recovery. Keeping you both in my thoughts and prayers.

[Ronald A. Primas,MD,FACP,FACPM @Primas]

Well said. While we gather this Memorial Day weekend with family and friends, enjoying BBQs, laughter, and the freedoms we often take for granted, let us pause to remember the brave men and women who made the ultimate sacrifice so that we may live free. Their courage, duty, and selflessness are the foundation upon which this nation stands, and we remain forever indebted to them.
May we never forget those who gave everything in defense of freedom and the values we hold dear. May they all rest in peace.
The more you sweat in peace, the less you bleed in war.

[Dalton (Analyze & Optimize) @Outdoctrination]

Glycine is a powerful sleep enhancer.

3g of glycine before bed:

⬩Increases subjective sleep quality
⬩Decreases time to fall asleep
⬩Increases cognitive performance the next day
⬩Makes falling asleep easier
⬩Lessened daytime sleepiness

in part due to glycine's ability to help regulate the circadian rhythm in the brain via the NMDA receptor in the SCN.

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@CharlesMullins2 Do you have a link to the clinical trial?

[Andrew Brack @BrackLab]

Treatment of frailty is effectively palliative care. We need to move on from exercise and protein shakes if we genuinely want to take people out of frailty.

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@davidasinclair Congrats to all of you!!! Well done!!!

[David Sinclair @davidasinclair]

Welcome, Mr. Simons 👏

[Bryan Johnson @bryan_johnson]

Talent is flowing to longevity

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@aubreydegrey Amazing Dynamic duo!!!

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@RobSheko This is great. Thx

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@DrMakaryFDA This is a major step. Organoids and organ-on-chip systems are promising, but the real inflection point will be how well these platforms are integrated with AI and human omics data to improve predictive validity over traditional models.

[Ronald A. Primas,MD,FACP,FACPM @Primas]

Nice work. This aligns with mTOR biology. Inhibiting that pathway around exercise will predictably blunt anabolic and training responses.
I would frame this less as rapamycin worsening outcomes and more as timing dependent interference. Spacing likely determines the result.
Would be very interesting to see the same protocol with dosing spaced away from exercise.

[Dr Brad Stanfield @BradStanfieldMD]

Our Rapamycin & Exercise clinical trial has just been published!

The topline result?

Rapamycin didn't help. Instead, it may have made things worse.

Here's what we found 🧵

https://t.co/vpy9bPrGDJ

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@agingdoc1 @mkaeberlein @soniaarrison @bettslacroix @KeithComito @joedesantis @KarlPfleger @eric_k_morgen @BreannaDeutsch @jenngarrison @NirBarzilaiMD @MartinBJensen @kpfortney Grateful to be working with you and all of our illustrious colleagues as well my friend!!!

[Ronald A. Primas,MD,FACP,FACPM @Primas]

@elonmusk It's amazing but is it HIPAA compliant?
Just curious. Thanks.

[Lifespan @JoinLifespan]

Trials are @lifebiosciences in Boston, an extraordinary company doing extraordinary things. Stay tuned for updates by following them & sign up @ https://t.co/SHqer8esdv

[Eric Topol @EricTopol]

More today on exercising fathers and metabolic health of offspring, summarized https://t.co/BMIvUaRjvD

[David Sinclair @davidasinclair]

Most breakthroughs like age reversal don’t happen in isolation. They happen when the right people, technology & mission align.

That’s why I’m building Lifespan

Follow the science. Join the community. Shape the future

[Ronald A. Primas,MD,FACP,FACPM @Primas]

I've always said this and enlighten my patients about thisMany other studies have similar findings. Light IS medicine! @MaxGulhaneMD @hubermanlab
https://t.co/rg4Z1yADU5

[David Sinclair @davidasinclair]

The link
https://t.co/T3WA3HhOQK

[David Sinclair @davidasinclair]

A new paper says lifespan gains will be small due to our biology

That’s true - if we don’t change. But if we can change our biological age, the equation changes

In 1700, we couldn’t imagine moving faster than a horse. Biology ruled. Then came the steam engine 🚂 🏎️ 🚀…