Gonda Imre

[Monique Straub @moniquesstraub]

I‘m happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬

More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here:
https://t.co/mpdxzbfNpQ

[Gonda Imre @Prolatium]

@seegerlab 🥩 Eat one more steak for me as well! 🥩😋🤠

[Vakil Takhaveev @vakil_takhaveev]

Check out our @NatMetabolism paper that advances the knowledge of eukaryotic cell cycle. 2/n https://t.co/vG1M4VYjiA @HeinemannLab @ResearchGbb @univgroningen @HorizonEU @MSCActions

[Hugues Abriel @[email protected] @SwissIonChannel]

Sonja Rutz from @DutzlerLab presents "Structure of a volume-regulated heteromeric #LRRC8 #ionchannel". Amazing structures! #TransCure2022

[Gonda Imre @Prolatium]

Fun experience in VR, you can even dance with your proteins! #TransCure2022

[Hugues Abriel @[email protected] @SwissIonChannel]

#VirtualReality helping @NCCR_TransCure scientists to understand the protein structures of @seegerlab at #TransCure2022. Super grateful to Luciano Abriata from @EPFL. @snsf_ch #agora

[Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. @annetkiraboc1]

Fantastic talk by ⁦@moniquesstraub⁩ #Switzerland @uniofbern #unibern! Great program Prof. @SwissIonChannel #TransCure2022!

[Annet Kirabo D.V.M., M.Sc., Ph.D., F.A.H.A. @annetkiraboc1]

Fantastic talk by ⁦@Prolatium⁩ at #TransCure2022 ⁦@NCCR_TransCure⁩ ⁦@seegerlab⁩ #Switzerland!

[Seeger Lab @seegerlab]

Our latest preprint is out🥳
https://t.co/7MfsLjMEPU
We performed DMS on EfrCD to determine the drug efflux activity profile of 1539 single variants!
Many interesting findings🔎, amongst which, that single mutations (!) can convert the exporter into a drug-specific ABC importer!

[Anastasiia Sukalskaia @asukalskaia]

TTYH proteins, AKA Tweeties, have long been mistaken for chloride channels. Unraveling the possible functional relation of the Tweety family to lipid transport and metabolism in our new paper out in @NatureComms: https://t.co/3TaP8prn58

[Oliver Adams @Oli_T_Adams]

Happy to say our cryo-EM structure of Mtb MmpL3 is now out in @Structure_CP! (https://t.co/7DKGUi3ZLk). Thank you to all co-authors for your hard work (@justindeme85, @S_M_Lea, @philipwfowler, @inwardopen & twitterless Joanne Parker)!

[Gonda Imre @Prolatium]

@moniquesstraub @seegerlab @structurabio Achieved by: @moniquesstraub @CarolinaAlvadia @MartaSawicka6

[Gonda Imre @Prolatium]

Nice structural work on a new protein family from the Dutzler lab! 👏🏻 Pushing the size limit of membrane protein cryoEM! 👀 Great use of sybodies (@seegerlab) and cryoSPARC (@structurabio). https://t.co/z0baWHeBiG

[Monique Straub @moniquesstraub]

Proud to share our latest cryo-EM structures on a yet unexplored, teeny-tiny member of the XKR family 🥳❄️🔬

[Vakil Takhaveev @vakil_takhaveev]

I am more than happy to share this beautiful story that was a big part of my PhD at @HeinemannLab @univgroningen @ResearchGbb https://t.co/UxK1hzLKaP

[Ali Punjani @a_punjani]

Continuous flexibility is the next frontier for #cryoEM.
We are thrilled to introduce 3D Flexible Refinement, a new deep generative model that solves both detailed non-rigid motion, and high-res structure of flexible proteins!!
https://t.co/k3y6LTThvL
https://t.co/rorutueufG
1/

[Seeger Lab @seegerlab]

Agonist-bound OX2R cryo-EM structure in complex with a conformation-specific sybody👏
https://t.co/D5QrsjpGM6
We are proud to have contributed to this seminal study of Kaspar Hollenstein from @Merck by generating a conformation-selective high-affinity (600 pM) sybody💪

[Seeger Lab @seegerlab]

Currently our institute is an island on the ocean of constructions🚧 Imre recorded and edited a video of our old lab building being teared down. CAUTION: catchy tune!😅😅 (song credit: Parry Gripp)

[Seeger Lab @seegerlab]

The Seeger Lab in 2020😀

[Seeger Lab @seegerlab]

📢Further progress at our COVID-19 front: six sybodies now characterized; decent binding affinities (20-180 nM); five sybodies strongly compete with RBD binding to ACE2; a sybody pair can bind simultanously.
Find the updated manuscript on @biorxivpreprint: https://t.co/q0RFr4iQYu

[Seeger Lab @seegerlab]

📽️IrtAB, an ABC transporter with an exporter fold, imports iron-bound mycobactins while the cytoplasmic domain (blue) reduces it to facilitate iron release. Our structure reveals a partially collapsed inward-facing substrate-binding cavity. Full story: https://t.co/1nCkcmsi5n