Jakub Schimmelpfennig

First steps as #psychedelics (DMT) and #consciousness researcher. Chief of Psychedelic and Consciousness Research Group on @SWPSUniversity
Neuropsychology 🧠 🍄

[Jakub Schimmelpfennig @psychedmt]

🧵 Endogenous DMT: What Do We Really Know?
Two recent papers shed new light on endogenous DMT, its biosynthesis, regulation, and function:
📄 Exploring DMT: Endogenous Role and Therapeutic Potential – by @psychedmt
📄 N,N-Dimethyltryptamine (DMT) in Rodent Brain: Concentrations, Distribution, and Recent Pharmacological Data – by Steven Barker
This thread summarizes key findings.

These studies challenge the idea that DMT exists in only trace amounts and has no biological role.

Let’s dive in. ⬇️🧵

[Earl K. Miller @MillerLabMIT]

Sleep pressure in flies is regulated by a rhythmic seesaw between two groups of neurons. This oscillation isn’t just a byproduct of sleep. It helps generate it.
https://t.co/h629RTRpGD
#neuroscience

[Robin Carhart-Harris @RCarhartHarris]

Formatted version of "The Entropic Brain Today" coming very soon...

[Robin Carhart-Harris @RCarhartHarris]

Big up, Lorenzo and co! https://t.co/zwuuMWLOyI

[James Murrough @JMurrough]

Excited to share this work from the amazing team at @IcahnMountSinai @MountSinaiNYC illuminating the brain dynamics underlying #depression. Major depressive disorder remains one of the leading causes of suffering worldwide. Our new work in @NatureComms uses advanced brain imaging and mathematical modeling to better understand how the depressed brain may become trapped in maladaptive patterns. The ultimate goal of our work is improving #antidepressant #treatment outcome patients.

[Captain Pleasure, Andrés Gómez Emilsson @algekalipso]

Published in Neurology, "the most widely read and highly cited peer-reviewed neurology journal", on June 9 2026

Results

From a total 248 completed surveys, 100 participants met criteria for cluster headache. Of these, 84% were male and average age was 49 years. The most common place to have learned about DMT treatment was social media/online. More than one mode of ingestion was often tried, but 75% had used a vape pen. Among those who used DMT to abort attacks (n = 85), the majority reported it completely eliminates pain (67.5%) and that it works every (45.7%) or almost every (35.8%) single time. Over half reported that DMT worked in under 30 seconds, and all participants reported either no change or an improvement in their health with DMT use.

[Sheila Macrine, Ph.D. @MacrinePhD]

How the Unconscious Blocks Distressing Language. Your conscious intuition says you can’t ignore a negative comment—but your nonconscious mind says otherwise.
A new study in Psychological Science reveals that when we are focused on a task, our brains actively filter out and suppress negative spoken words before they ever reach conscious awareness.
Rather than letting threatening language hijack our attention, the brain acts as an automated "cognitive gatekeeper," shielding our limited mental resources from costly, distressing distractions. Interestingly, researchers hypothesize this protective filter might break down in clinical populations dealing with anxiety or PTSD. https://t.co/tInX0NaGST https://t.co/NZIkK3U5jh
#Psychology #Neuroscience #CognitiveScience #BrainResearch #Consciousness #MentalHealth #BehavioralScience

[Julie Holland, MD @BellevueDoc]

The Allostatic Reset Model (ARM) of Psychedelic Action https://t.co/RxoMwKwIdo via @OsfFramework

[Johns Hopkins Psychedelic Research Center @JHPsychedelics]

CPCR Director @FredBarrettPhD quoted in @AP “It’s been incredibly difficult to study ibogaine in the U.S. because of its known cardiotoxicity... If the executive order can pave the way for doing objective, scientific research with this compound, it would help us understand whether it is truly a better psychedelic therapy than others.” https://t.co/rwBlMuJiX7

[Sheila Macrine, Ph.D. @MacrinePhD]

Is forgetting the secret to intelligence? An epic roundtable with Michael Levin, Karl Friston, Mark Solms, Richard Watson, and Alexey Tolchinsky break down why selective forgetting is absolutely essential for cognition, agency, and building a coherent sense of self.
A fascinating deep dive into the mechanics of the mind! https://t.co/zmDsc5Sutm
#CognitiveScience #Neuroscience #PhilosophyOfMind #Psychology #MichaelLevin #KarlFriston @drmichaellevin @alexeytolchinsky @Mark_Solms @RichardWatson90
@tolchinsky.bsky.social

[Julie Holland, MD @BellevueDoc]

An international mega-analysis of psychedelic drug effects on brain circuit function

lots of great researchers involved in this paper.

(whole article)

https://t.co/vKhH0duJqv

[Earl K. Miller @MillerLabMIT]

Adult brains operate near a “critical point” of balanced excitation/inhibition, enabling more coordinated rhythms and greater efficiency.

Brain criticality emerges with developmental shifts in frequency-specific excitation-inhibition balance
https://t.co/LcaRQCll0W
#neuroscience

[Earl K. Miller @MillerLabMIT]

Action potentials are only one layer of brain computation.
https://t.co/dwm2jJSIAH
#neuroscience

[Earl K. Miller @MillerLabMIT]

New discovery! Different anesthetics all seem to push the brain into unconsciousness in the same way: Activity is destabilized and dominated by slow waves. This could block signals.
https://t.co/bUPlOMWM3K
#neuroscience @MIT_Picower @mitbrainandcog @mcgovernmit @ScienceMIT

[Robin Carhart-Harris @RCarhartHarris]

"It's not magic, it's psychology."

[Sheila Macrine, Ph.D. @MacrinePhD]

Emerging evidence shows higher cognition relies on rhythmic electric fields—acting like "radio waves"—to enable large-scale organization, executive control, and energy-efficient analog computing. Catch Professor Earl K Miller’s Presidential Special Lecture at Neuroscience 2025 https://t.co/1Yn643l4KT @MillerLabMIT
#Neuroscience #Bioelectricity #CognitiveScience #AnalogComputing #SfN25

[Robin Carhart-Harris @RCarhartHarris]

I read this recently: https://t.co/uHMlSzFV0J It says 2A blocker studies often "over-dose the blocker" and thus lose specificity to 2A. Could this apply here? https://t.co/mr1DiR52Rp

[Robin Carhart-Harris @RCarhartHarris]

Buzzy times: https://t.co/IAOBsGQkvi

[David Luke @drdluke]

Ecodelia and the lost art of lichenthropy - On becoming fungus on acid and on being publicly ridiculed by grass on Salvia

My latest Substack exploring the psychedelic experiences leading folk to connect & communicate with, or transform into other species

https://t.co/7f4YC1Up8S

[Alex Fornito @AFornito]

Interested in cortical wave dynamics?

Check out our review on the physics, physiology, and psychology of cortical waves led by J Cruddas with @jchrispang

Out now in @NeuroCellPress

https://t.co/2xxP6hYjaJ

[Robin Carhart-Harris @RCarhartHarris]

This is significant: https://t.co/qGETU7CdPC