Damian Elle

[Anish Koka, MD @anish_koka]

On June 30, 2026, the NEJM retracted the clinical trial that got a drug approved by the FDA, triggering a $3.7B acquisition by Amgen.

The reason: the primary endpoint data was manipulated.

Here's how it happened, how it came to light, and who paid the price. 🧵

[Damian Elle @quackingmo]

@jawnzilla i would be wary of anything this guy claims he “hears”

[Damian Elle @quackingmo]

"3-4 months"

[Damian Elle @quackingmo]

$lrmr would be good to know how big a dosing gap has to be to count as re-exposure – is it fair to ask daily subq patients to never miss a dose?

[Damian Elle @quackingmo]

@jensenjeans you keep your silverware in a cupboard?

[Damian Elle @quackingmo]

@ShortSeller

[Damian Elle @quackingmo]

@AppieAnanas @Longroaderstar i’d argue inter-EON variance is actually probably too great and sequence/mod-dependent to make any platform-based learnings on the translational PK/PD side, but sure it’d at the very least validate their internal modelling.

[Damian Elle @quackingmo]

@Longroaderstar @AppieAnanas data from a single oligo is not gonna make a dent in any model’s performance

[Damian Elle @quackingmo]

$sgmo I mean, what did you lot honestly think was going to happen ???

[Damian Elle @quackingmo]

@TrueTrueIke seems to be quite a reasonable Prasad/Makary-reversal target, surprising that the stock’s not reacted

[Damian Elle @quackingmo]

the year is 2037. $ALNY have entered their 12th TTR molecule into the clinic - this time with q10y dosing. the patients rejoice.

https://t.co/xqUhCmY8l7

[Damian Elle @quackingmo]

@BiotechAnalysst if you think the reason $sgmo is priced the way it is is because of uncertainty over ST-920 efficacy, I don’t think you’ve been paying attention over the past few years

[Damian Elle @quackingmo]

$prqr

[Yair Einhorn @yaireinhorn]

1/🚨WOW! $LLY continues to strengthen its leadership position in the Gene & RNA Editing space with its recent p announcement of a $1.9B collaboration & licensing agreement signed with Ascidian Therapeutics to develop RNA-editing therapies 🧵👇for undisclosed kidney diseases. $XBI

[Sasha Gusev @SashaGusevPosts]

Writing my instructions for Claude ..

[pharmabro @pharmabro0782]

$xbi

[Damian Elle @quackingmo]

$tnya nice. shits on $lxeo from where i'm standing.

[Damian Elle @quackingmo]

@BGatesIsaPyscho shocking the amount of people who can’t recognise a fake video

[Matthias Schmidt @eurofounder]

If the EU built Claude