Many chronic diseases have a common denominator that could be driving their dysfunction: reduced protein mobility, which in turn reduces protein function. A new paper from @youngricka's lab describes this pervasive mobility defect: https://t.co/2BxETPuCra
@CellRepJrnl@eskamoah@cc_biology_@rejuvenatebio Both promising that there was some life extension and disappointing in that the modest effect shows either that partial of epigenetic age was too partial, perhaps due to technical reasons, or that epigenetic age reversal is not the whole story when it comes to rejuvenation.
Bitcoin is engineered to have an artificially limited supply on the one hand, but is easily clonable given its open source nature on the other. That such clones haven't gained traction is just a matter of hype and fashion. The extreme volatility of bitcoin makes it an unsuitable world currency, which could destabilize global economic activity.
@AgingBiology Predictions about such extended human longevity should probably be considered highly speculative. OTOH there is great potential to reverse aging at the epigenetic level.
@migtissera You forgot
2020: AlphaFold which allows prediction of protein structure, winning the 2023 Lasker Prize for DeepMind inventors Hassabis and Jumper, but really for AI.
@Cal_Engineer This is an underappreciated paper so far-- certainly quite consequential regarding earlier DNA clock-based publications. Would be useful to reevaluate raw data from those using Conboy's new model.
@prof_horvath How can these results be reconciled with David Sinclair's recent study that presented evidence that ds DNA breaks could drive epigenetic aging (such as DNA methylation clocks)?
Focusing on the ageing brain, they show that "activation of STING triggers reactive microglial transcriptional states, neurodegeneration and cognitive decline."
Nature: cGAS/STING play a major role in inflammaging. The author's show that "cGAS–STING signalling pathway, which mediates immune sensing of DNA, is a critical driver of chronic inflammation and functional decline during ageing." https://t.co/RCvb9cRiLw
@stackhodler The Bitcoin bubble is the consequence of creating a system appealing to insatiable greed: synthesize money out of the ether, and then make it increasingly more difficult to do so with time. Just needs publicity and herd mentality to work. Appeals to humanity's basest instincts.
@itsPaulAi Beware!!! Just tried a version of this on a search related to frontotemporal dementia and Bard like ChatGPT fabricated references. I even added seatch Google Scholar and it still persisted in this.
@elonmusk Give us the ability to increase the frequency of seeing certain topics and people by creating a rating scale for users. No need to make it public, just have twitter use it internally.
@ylecun True, OTOH there will be benefits to allowing AI free rein in terms of greater creativity if nothing else. Therefore there is and will be motivation to create such entities.
@UrnovFyodor Good idea, but it would need to have a near complete set of papers as a database. Currently, perhaps only a few organizations (Google?, a few of the biggest universities) have sufficient access to create the database.
@heykahn Actually the technology underlying ChatGPT will replace many jobs in addition to saving people work. Think about it this way, if you are correct, and 100's of hours of work are saved for each person, then not as many people are needed at a workplace.