Rachel Yan

MD/PhD student (MS4) interested in neurosurgery and developing platforms for personalized medicine @RWJMS @nygenome @CBTP_lab

[Rachel Yan @rachyan_]

So honored to be featured on the cover of @NatureBiotech this month!

[Nature Biotechnology @NatureBiotech]

The October issue is live https://t.co/uEGWhO2B55

The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state https://t.co/KcjY604fNf

[Jonathan H Sherman, MD @ShermanMDneuro]

Attend the Second Annual International Brain & Spine Tumor Symposium to learn from national and international experts, at NJ's only NCI-designated
Comprehensive Cancer Center.
https://t.co/y5ACb39V7O

[Tim Stuart @timoast]

Pleased to share the beta release of Signac v2 today. This release makes some important changes, including support for BPCells matrices for large-scale analysis. Documentation can be found here: https://t.co/VAYTJX05h4

[Rachel Yan @rachyan_]

@michaelrallo95 Congrats Mike!!

[Neville Sanjana @nevillesanjana]

Delighted to share new work from our lab: CRISPR fusion proteins to boost PRECISE genome editing (TruEditors).

We wondered what if we could “turn on” and test every gene in the human genome to accelerate protein design?

[Rachel Yan @rachyan_]

Pleased to share CRISPore-seq, which expands single-cell CRISPR screens to isoform resolution using long-read sequencing. Grateful to @nevillesanjana and my co-lead authors @drsimonmueller, @nathan__andrews, and @akashsookdeo100, whose foundational work made this possible.

[Neville Sanjana @nevillesanjana]

Looking for some Thanksgiving reading? 🦃🦃🦃

🚨Check out our new preprint on CRISPore-seq!🚨

Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.

[Rachel Yan @rachyan_]

@hannahkhanshali @nevillesanjana @NatureBiotech thanks @hannahkhanshali!!

[Rachel Yan @rachyan_]

@foodskop @nevillesanjana @NatureBiotech Thanks so much @foodskop!!

[Nature Biotechnology @NatureBiotech]

The October issue is live https://t.co/uEGWhO2B55

The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state https://t.co/KcjY604fNf

[Rachel Yan @rachyan_]

Huge thanks to my mentors @nevillesanjana, Jeffrey Greenfield, Nadia Dahmane, Shridar Ganesan, my teammates @nygenome @CBTP_Lab @RWJMS, and especially @SciStories for the beautiful art!

[Rachel Yan @rachyan_]

So honored to be featured on the cover of @NatureBiotech this month!

[Nature Biotechnology @NatureBiotech]

The October issue is live https://t.co/uEGWhO2B55

The cover shows perturbations that convert stem-like, atypical teratoid rhabdoid tumor (AT/RT) cells into a more differentiated, neuron-like state https://t.co/KcjY604fNf

[Rachel Yan @rachyan_]

Check out this thread for more https://t.co/gMgVkvQiBi

[Neville Sanjana @nevillesanjana]

Delighted to share new work from our lab:
MultiPerturb-seq 🎛️❌📥📤

Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.

[Antonio Santinha @AntonioSantinha]

In vivo CRISPR screens offer a unique way to study gene function at scale🐁. In our new @NatureRevGenet article, Alessio Strano, @randall_platt, and I review current methods, experimental designs, and explore exciting future directions!https://t.co/L1HGdoEgks

@ETH_en @ETH_BSSE

[10x Genomics @10xGenomics]

High-throughput #singlecell #CRISPR screens are unlocking #cancer drug targets + gene mutation functions. Read more in our blog, and learn how GEM-X Flex Gene Expression can make scalable CRISPR screens more accessible than ever: https://t.co/a9axvyhN0L

[Rachel Yan @rachyan_]

@vishali_moond @rutgershealth @SPUHIMresidents Congrats Vishali!!

[Ryan Denu, MD, PhD @RyanDenu]

Thanks @meburkard for stopping by my poster today at #AACR25
Forever grateful for your mentorship.
Iowa is very lucky to have recruited you to direct their cancer center.
@UWMSTP

[Vijay Sankaran @bloodgenes]

Delighted to have our Perturb-multiome paper, led by @jmartinrufino and #AlexisCaulier from our lab, published today in @ScienceMagazine. Please check out this powerful approach to decipher gene regulatory networks enriched for genetic variation: https://t.co/TOhYCqOvO1

[Chenxu Zhu @chenxuzhu]

We're incredibly excited to share our new method, Paired-Damage-seq, out @naturemethods today! This technique allows us to jointly analyze oxidative DNA damage and SSBs with RNA, all at the single-cell level (1/5). https://t.co/epPZuVC1jA

[Rachel Yan @rachyan_]

Fantastic event - thank you for having us!

[India Shelley @indiashelley]

Phenomenal day of learning and networking at our 3rd annual @TJUHNeurosurg Bootcamp! Such a great time welcoming over 40 students from 20+ institutions 🧠

[Rachel Yan @rachyan_]

@Chandler_Berke Congrats Chandler!!!

[Raimondi Ivan @raimondi_ivan]

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: https://t.co/mfsDO3kKa0 #Genomics #Epigenetics