Raik Grünberg

biochemist turned structural bioinformaticist turned synthetic biologist engineering and tormenting proteins, cell-free systems and robots

[Raik Grünberg @raikgruenberg]

Our paper on the first biosynthesis pathway transplantation into living cells is out and featured in a KAUST press release.

[KAUST @KAUST_News]

KAUST researchers have achieved a world first: six proteins delivered into living cells, working together as a single system. The most complex protein delivery ever recorded.

Read the story: https://t.co/I9e4K0kjNB

[Raik Grünberg @raikgruenberg]

#Proteins are team players! We have packed a six-protein biosynthesis #pathway into #MOF #nanoparticles and turned them into #SyntheticOrganelles for intracellular #drug #biosynthesis -- The most complex protein system yet delivered into cells. Preprint: https://t.co/UhVMucAfJc

[Raik Grünberg @raikgruenberg]

@AcrossTheMersey There is zero evidence for a bone marrow viral reservoir in this paper. They do not even look at this question. They find that monocytes of PASC patients show moderate, barely significant, loss of respiration efficiency. The rest is speculation.

[Nature Custom Media @NatureCustom]

A new diagnostic test, developed by KAUST scientists, can deliver highly accurate results in less than 15 minutes. @STRUBE_KAUST @InalSahika [Partner content with @KaustResearch]

[Raik Grünberg @raikgruenberg]

Our #bioelectronic #COVID19 sensor is now officially published. Proud to be part of this fantastic collaboration. Protein #synbio meets material science for fast single molecule protein detection. Stay tuned for further adventures! https://t.co/eybWCSUkPf

[Raik Grünberg @raikgruenberg]

@rjerala There was press coverage over here that China is testing a vaccine in UAE. Apparently they have trials running in Brazil, too: https://t.co/bBFMrrhqTi That should give them plenty of cases...

[Raik Grünberg @raikgruenberg]

Thanks @XavierPita_ for a fantastic textbook-level illustration.

[Sahika Inal @InalSahika]

See our #bioelectronics efforts on making rapid tests for #COVID19 available
A nanobody-functionalized organic electrochemical transistor for the rapid detection of SARS-CoV-2 or MERS antigens at the physical limit https://t.co/ZHviWWfuT8 Hope such sensors will make a difference

[Raik Grünberg @raikgruenberg]

Fantastic collaboration with the team from @InalSahika. A special shout-out to @maxmoser29 for a magic semiconductor material and to @FatimahAlhamlan and KAUST Health for making measurements on clinical #COVID19 samples possible. And we just got started :)

[Sahika Inal @InalSahika]

See our #bioelectronics efforts on making rapid tests for #COVID19 available
A nanobody-functionalized organic electrochemical transistor for the rapid detection of SARS-CoV-2 or MERS antigens at the physical limit https://t.co/ZHviWWfuT8 Hope such sensors will make a difference

[Raik Grünberg @raikgruenberg]

@rjerala I Chinese student of ours who is still stuck back home already got a vaccine there too. Are there any data on that one?

[Raik Grünberg @raikgruenberg]

ELISA get ready for retirement! Here comes rapid and robust single-molecule protein (and virus) sensing from raw saliva or serum https://t.co/IyQTb54AS3 #coronavirus #synbio #diagnostics

[Raik Grünberg @raikgruenberg]

@emulenews This paper doesn't meet any scientific standards -- there is no information whatsoever about what antibody or what virus proteins they used. Also, no negative controls, no replicates.

[Raik Grünberg @raikgruenberg]

@hsalis What about the barcoding? You still have to put every single sample into the well oof a 384 plate. Putting that plate into a qPCR straight away would be much easier, cheaper, and faster, wouldn't it?

[Raik Grünberg @raikgruenberg]

@hsalis A pretty run-of-the-mill qPCR instrument with two 384 well blocks can analyze 500 patient samples per hour (2 virus genes plus positive control per patient). That's 4 h for 1000 patients. And those devices are much more common and much cheaper than sequencers.

[Raik Grünberg @raikgruenberg]

@hsalis I don't really get what's the point of sequencing if you can detect more cheaply and *much* more rapidly by RT-PCR? Plus I think there is RT-PCR protocols that skip RNA extraction. lysis is enough.

[XKCD Comic @xkcdComic]

Robot Future https://t.co/V33IIMjm4q https://t.co/WGZdHxnNLB

[Edward Snowden @Snowden]

Businesses that make money by collecting and selling detailed records of private lives were once plainly described as "surveillance companies." Their rebranding as "social media" is the most successful deception since the Department of War became the Department of Defense.

[Sri Kosuri @srikosuri]

Excited to release DropSynth to the world. Congrats to @calinplesa @nathanlubock @angus_sidore . You can find out more on our blog post on the work: https://t.co/8Eh2bLVpGP

[Raik Grünberg @raikgruenberg]

A nice antidote to the current blockchain and crypto cyrrency madness
https://t.co/jjF1bTBci9

[Raik Grünberg @raikgruenberg]

@jimhaseloff The mCitrine extinction is also at least 30% too high. So don't use this table as a reference for anything related to concentrations.

[Raik Grünberg @raikgruenberg]

@jimhaseloff purification without gel filtration (from Top10?!), BCA concentration...renders extinction coeff and thus Q, and brightness worthless. E.g. I have measured mCherry E=60.000, consistantly, in 3 different labs and in 10+different fusions.