Raúl Padrón

Curiosity-driven research rules! Muscle Structural Biologist, Professor. UMass Chan Medical School, Division of Cell Biology and Imaging, Padrón-Craig Lab.

[Raúl Padrón @raulpadron]

Our paper is now in @Nature: #CryoEM 6 Å reconstruction of #human cardiac thick filament C-zone in #mavacamten, showing #myosin heads, tails, #titin, #MyBP-C. Many implications for a 60-year mystery on #cardiac #muscle #physiology, #structure and #disease.
https://t.co/oUeBWQOyyt

[Raúl Padrón @raulpadron]

https://t.co/Qc9UIY4zIz

[Raúl Padrón @raulpadron]

https://t.co/oPSlYuFRcA

[Raúl Padrón @raulpadron]

https://t.co/oPSlYuFRcA

[UMass Chan Medical School @UMassChan]

How can you not smile at this photo of one Nobel Laureate from @UMassChan, Craig C. Mello, PhD, taking a selfie with another, Victor R. Ambros, PhD? Dr. Ambros was named the co-recipient of the 2024 Nobel Prize in Medicine or Physiology on Oct. 7. #NobelPrize @NobelPrize @UMass

[UMass Chan Medical School @UMassChan]

Learn about UMass Chan Medical School’s newest Nobel Laureate, Victor R. Ambros, PhD: https://t.co/ga9J4gLTn0

This morning, Dr. Ambros learned that he is the co-recipient of the 2024 @NobelPrize in Physiology or Medicine for the discovery of microRNA. #NobelPrize @ProgMolMed

[nature @Nature]

This week in Nature: Beat generation - molecular structure of the myosin filaments that power the heart

Browse the full issue: https://t.co/Qs79zemlnf

[Raúl Padrón @raulpadron]

@JulienPaganin @Nature Thanks Julien!

[The Shaw Prize @ShawPrize]

“While science can be a challenge… All that pales in comparison to the thrill of the questions to be asked, of seeing them answered one day.”
Prof. Eva Nogales’ acceptance speech at 2023 #ShawPrize Award Presentation Ceremony.
https://t.co/4dHX3KNbX2
@NogalesLab @UCBerkeley

[Nature News & Views @NatureNV]

Thick filaments help the heart to beat.

Peter Knight @AstburyCentre @ScienceLeeds discusses structural evidence that provides new insights about these myosin-containing filaments. https://t.co/HntBdCddlt

[Nature Reviews Cardiology @NatRevCardiol]

Two papers in @Nature describe the structure and conformation of myosin in the cardiac thick filaments and how it interacts with other proteins, such as titin and cMyBP-C, in mammalian hearts ($): https://t.co/4AHuRtxAWJ @DvdGently, @intein, @raulpadron #ResearchHighlight

[Raúl Padrón @raulpadron]

@JulienPaganin Congrats to Julien and Anne!

[Julien Robert-Paganin @JulienPaganin]

Really proud to share our last preprint on Omecamtiv and Mavacamten, two modulators of cardiac myosin. Years in the making. Very happy to work with the team, especially Anne, Carlos, Daniel & Stéphane on this paper.

https://t.co/s7ZeIwbCey

[Campbell Muscle Lab @ UKY @CampbellLabatUK]

Excited to have played a small part in this amazing study in @nature by Drs. Dutta, Nguyen, Padron, and Craig from @UMassChan, @umassradiology.

Thank you to the patients and families who made it possible. Let's hope the research accelerates therapies.
https://t.co/2diFuCFNp1

[nature @Nature]

Nature research paper: Cryo-EM structure of the human cardiac myosin filament https://t.co/Mx19b3LbV8

[nature @Nature]

Nature research paper: Structure of the native myosin filament in the relaxed cardiac sarcomere https://t.co/g1mgGm5MXm

[nature @Nature]

Thick filaments help the heart to beat.

Peter Knight @AstburyCentre @ScienceLeeds discusses structural evidence that provides new insights about these myosin-containing filaments. https://t.co/gw50YnVPrF

[Raúl Padrón @raulpadron]

The @UMass Chan Padron-Craig lab PDB 8G4L atomic structure was achieved at the @UMass Chan Cryo-EM Core, superbly staffed and equipped (@thermofisher Titan Krios, Talos-Arctica, Glacios), providing excellent hands-on training.
https://t.co/bxYDLYSZGA
https://t.co/w4r7L3oKMu

[Raúl Padrón @raulpadron]

PDB 8G4L atomic structure of #human #cardiac #myosin thick filament released: it resolves past uncertainties & integrates previous data on cardiac #muscle structure & function.
https://t.co/9b9MNtmbVI
https://t.co/5ORASCEtyV
https://t.co/9J9j3kpaZs

[Raúl Padrón @raulpadron]

@UMass Chan cryo-EM Core is superbly staffed and equipped to carry out our work (@thermofisher Titan Krios, Talos-Arctica, Glacios, with K3 cameras and energy filters, Aquilos FIB-SEM, etc.) and to provide excellent hands-on training
https://t.co/CuJlRt2PBW