MDMA plus high-dose psilocybin was the hardest psychological work Andrew Huberman has ever done.
He is explicit: no one should try this without clinical support, and many people should not take these compounds at all. He has only done the combination twice.
MDMA first created the empathogen effect that made difficult material approachable. Psilocybin alone at four to five grams of dried mushrooms had been terrifying and physically harsh.
Together, the MDMA allowed him to stay with the hardest childhood material instead of pushing it away. He also reported no typical post-MDMA drop.
Both compounds increase neuroplasticity in different ways, MDMA primarily through elevated serotonin and oxytocin systems, psilocybin through 5-HT2A receptor activation, which may explain why the sequence felt uniquely intense and why the usual comedown was absent.
Huberman has a rare ability to describe extreme personal experiences with precision, honesty, and strong caveats. That combination is what makes his accounts trustworthy.
Alzheimer’s can be stopped
Here’s everything you need ⬇️
https://t.co/xuAQMYdWcK
It’s not a neurological disease
It’s not genetic…
the nonsense being thrown around
about APOE4 is ridiculous
It’s a metabolic disease
Period
2023 The Lancet proved those with preserved insulin sensitivity
low systemic inflammation
and robust mitochondrial function
had dramatically lower Alzheimer’s risk
even when they carried APOE4
The genes don’t matter
the metabolism does
Insulin resistance is the catalyst
the metabolic crisis fires up the immune system and the resulting chronic inflammation destroys the mitochondria that should be saving you
Current Alzheimer’s & dementia treatment, involves best selling authors spewing garbage
anti amyloid monoclonal antibodies and tau targeting to scrub amyloid plaques
& tau tangles…
which does nothing
2017 the AMBAR study & multiple follow up studies proved aggressively removing tau and amyloid doesn’t reverse cognitive decline whatsoever
290 billion dollars…
300+ clinical trials…
yet increased disease progression
and you guys still have to watch loved ones disappear
because they’re treating the wrong thing
It’s not a failure of research
it’s a failure of the damn hypothesis
But I’m not a billion dollar pharmaceutical company with a marketing budget of a small country…
I’m the doctor GIVING you solutions every day for free because I love you enough to give a crap about your health & life
Never Miss
Dr Trevor Bachmeyer
The Spartan
One of the best demonstrations of BPC-157’s effectiveness is what it does for dogs.
Dogs can’t experience a placebo effect.
When they go from "almost dead to running again" you need to pay attention.
Andrew Huberman says BPC-157 has almost no good human data.
And almost everyone in his world is taking it.
Animal studies show it regrows cartilage, nerves, and blood vessels.
The lethal dose is so high Huberman doesn't think anyone has ever hit it.
But there's not a single controlled human trial for wound healing.
The only human study involved enemas at massive doses for colitis.
That's it. That's all the science has.
Yet millions of people are injecting it because the anecdotal results are impossible to ignore. Injuries that doctors said wouldn't heal—healing.
— Andrew Huberman on TBPN (@tbpn)
BPC-157 has its limits. Disc pain and nerve pain is one of them.
That's where ARA-290 comes in.
→ Developed for diabetic neuropathy and chronic pain
→ Start at 1mg, work up to 4mg
→ Stack with Cartilax for disc issues
One of my favorite tier 2 peptides not enough people know about.
Peptides are the hot topic, and that means a vast array of science, opinions, and promises.
The gap between casual peptide culture online and the published human data is wider right now than it has been at any point in this space. The goal of this episode is to create a baseline for conversation and understanding.
What we know and what we don't, and where is the future of peptide science.
Watch the full episode here on X!
This doctor has treated 100,000+ patients with peptides, with almost no side effects.
After watching his full interview with Gary Brecka, I pulled out his 7 wildest takes that will change the way you see peptides:
(1/7) Peptides > Aderall
Do you take peptides?
Do you trust them?
I do and I also trust my peptide source. @nexgenpeptides is USA Finished using pharmacy grade FDA compounding pharmacy standards. Sterile, Isotonic and pH balanced.
Use coupon code “Lobliner” to save - these are the real deal!
Amazing news for peptides!!!
RFK Jr. just announced on the Joe Rogan podcast that within the next few weeks 14 peptides (of 19 total) will be able to be compounded again legally in the United States.
That’s what I call progress!
RFK Jr. says the FDA’s war on peptides and other alternative medicines is over.
“We’re gonna end the war at the FDA against alternative medicine.”
“The war on stem cells, the war on chelating drugs, the war on peptides, the war on vitamins.”
“The FDA has a job to do the science on these kind of issues.”
“And then tell the public what they've learned from the science.”
“But not tell people and not tell physicians what they can and cannot prescribe.”
This is the stack I used to heal Leaky Gut:
• BPC157 1mg 2x per day
• TB500 1mg 2x per day
• KPV 0.5mg 2x per day
• GHK-Cu 1mg 2x per day
Ran this 5 days on, 2 days off and had 99% relief from carb intolerance after 12 weeks.
PS. Full disclosure:
I was also working with a functional medicine practitioner at the same time on a gut microbiome rehab protocol, which also contributed to resolving my leaky gut symptoms. However, it was early into that protocol, and the practitioner agrees peptides helped my healing significantly.
(If you want more information on who my medical practitioner was, send me a private message)
In this episode, @BenGreenfield joins me to explore everything from cold plunges, red light therapy, hyperbaric oxygen, peptides, and stem cells to exercise, recovery, and metabolic health. Watch now.
#TheSecretaryKennedyPodcast
Jeremy Renner casually listing peptides tells you where this market is going.
Thymosin. BPC-157. MOTS-c. TB-500. NAD. Hormones.
The celebrity stack gets attention.
The biology decides whether it makes sense.
Same peptide. Different body.
This is the COMPLETE Peptide Tier List compilation — Parts 1 through 3 combined into one deep dive.
We break down the most talked-about compounds in fitness, longevity, anti-aging, and fat loss: Semaglutide, Tirzepatide, Retatrutide, Mazdutide, Growth Hormone (HGH), HCG, IGF-1 LR3, Tesamorelin, Sermorelin, CJC-1295, Ipamorelin, BPC-157, TB-500, NAD+, Melanotan, Selank, SEMAX, MOTS-C, Kisspeptin, Insulin, and more.
If you’ve ever searched: • Best peptides for fat loss • Best peptide for muscle growth • GLP-1 vs growth hormone • Is BPC-157 legit? • Is insulin dangerous for bodybuilding?
This thread answers it.
We cover: ✔️ Real human data vs hype ✔️ Fat loss vs muscle-building compounds ✔️ GLP-1 agonists (semaglutide, tirzepatide, retatrutide) ✔️ Growth hormone secretagogues ✔️ Longevity + nootropic peptides ✔️ The compounds people massively overestimate
Some are revolutionary. Some are promising. Some are pure internet fantasy.
This isn’t bro science. It’s mechanism + data + real-world application.
If you’re considering peptides for weight loss, muscle gain, performance, anti-aging, or cognition — read this before you inject anything.
👇 Which compound surprised you the most?
The FDA has created a huge black market.
By banning American suppliers from selling most peptides, they enrich shady Chinese peptide sellers.
How exactly does that keep people safe?