Regenerative Science

#Syntheticbiology, #aging, #regenerativemedicine, scientistexplorer/#entrepreneurs, tech innovation, #STEM. Tweets by RSI Director of Research Andrew Mendelsohn

[Regenerative Science @regensci]

A recent in depth review of the mechanisms underlying DNA methylation in mammalain epigenetics: https://t.co/LpkoJt4wT6

[Regenerative Science @regensci]

@davidasinclair posts an Information loss theory of aging. While mostly correct, it is really just a restatement that the epigenetic drift that is well known to occur with aging underlies much of aging-associated phenotypic dysfunction. https://t.co/GlVlz7nwCQ

[Regenerative Science @regensci]

A better understanding is needed of how epigenomes are maintained in dividing and quiescent cells integrating DNA methylation, histone organization/modifications, trx factors, non-coding RNAs etc. Good models would be profoundly important in aging, cell differentiation and cancer

[Regenerative Science @regensci]

Reference for Nature paper describing PF4 Platelet attenuating inflammation and increasing cognition in ageing mice. CXCR3 is a receptor in this.
https://t.co/BLWQnzw7I1

[Regenerative Science @regensci]

PF4 helps maintain youthful brain function + rejuvenates cognitive function + neurogenesis in old mice. It is induced by klotho, decreases with age, increases with exercise and suppresses brain inflammaging. https://t.co/C0xvJRVxOp https://t.co/BLWQnzw7I1 https://t.co/zDCWBtGvt7

[Regenerative Science @regensci]

Reference for PF4 being induced by longevity associated factor klotho and enhancing cognition in mice. https://t.co/C0xvJRVxOp

[Regenerative Science @regensci]

Reference for PF4 increasing with exercise and promoting hippocampal neurogenesis and cogntiion in old mice. PF4 could be a major source of young blood's reported rejuvenation capability. https://t.co/gz6Pq64ARY

[Regenerative Science @regensci]

"cGAS–STING signalling pathway, which mediates immune sensing of DNA, is a critical driver of chronic inflammation and functional decline during ageing" via triggering "reactive microglial transcriptional states, neurodegeneration and cognitive decline" .https://t.co/AfdKUxOi1U

[Regenerative Science @regensci]

The paper https://t.co/RsBPEZdsiY
makes the case for using reprogramming factors to induce dedifferentiation followed by redifferentiation, which we and others have long hypothesized the key to reverse aging. https://t.co/c2zTDsw2Ws from 2015.

[Regenerative Science @regensci]

Major evidence for the key role for epigenetics in aging from @davidasinclair Repair of artificial non-mutagenic DNA damage causes loss of epigenetic information, accelerating aging in mice. Crucially reprogramming factors OSK reverse aging aspects.

[Regenerative Science @regensci]

2 recent papers use limited Yamanaka factor reprogramming to rejuvenate mice. Serrano's group achieved better aging phenotypes in more varied tissues than Izpisua Belmonte's. Likely due to differing OSKM expresson patterns in doxy inducible mouse strains! https://t.co/zKEtSqiTiu

[Regenerative Science @regensci]

2 problems for human rejuvenation by partial reprogramming: 1) limited tissue susceptibility, 2) species differences may make it more difficult in human cells. And Yamanaka factors are potential oncogenes (not just c-myc). Lots of work ahead! Altos labs will need the big checks!

[Regenerative Science @regensci]

Long-term whole body partial reprogramming using Yamanaka factors can partially reverse epigenetic and functional age in the skin and kidneys of middle-aged mice. Promising result BUT rejuvenation may be more difficult than first suggested in 2016. No other tissues affected!

[João Pedro de Magalhães @jpsenescence]

Wow, new study from @altos_labs on long-term (7-10 mos) partial reprogramming in aging mice. In vivo reprogramming is safe, reverts the epigenetic clock and delays aging phenotypes. No effect on survival but they don't show the lifespan of treated mice.

https://t.co/slFvHxSEJ8

[Regenerative Science @regensci]

Keep in mind that conventional reprogramming by Yamanaka factors to IPSCs is much easier in mice than human cells because murine cells are more plastic with respect to differentiated state-- probably due to weaker anti-cancer protection in mice. So 2 problems to overcome...

[Regenerative Science @regensci]

We've just published a review on the progress and prospects of anti-aging vaccines. The PDF is currently accessible here https://t.co/5JdqmUPxtv
and here is the abstract: https://t.co/wnvOyw7Maj

[Regenerative Science @regensci]

First-in-class senolytic drug UBX0101 that breaks p53/MDM2 interaction has failed in a clinical trail to relieve pain in osteoarthritis. Are senolytics more effective in mice than men? Perhaps needs to be combined with an anti-inflammatory drug in people. https://t.co/sKWUxm5hFs

[Regenerative Science @regensci]

bioRxiv viewer https://t.co/g14EnsuBCM Rejuvenation of rats using a young blood fraction is being taken seriously. David Sinclair, PhD@davidasinclair, who has done extensive research on NAD+ and resveratrol wrote a series of tweets on May 11 here: https://t.co/xd0DQw6bhe

[David Sinclair @davidasinclair]

Finally had time to carefully read the new preprint that claims to reverse the age of rats by 54%. I spoke to the first author & in this thread ask whether the results are believable and what if it is true? https://t.co/Odcd24slwe 1/n

[Regenerative Science @regensci]

The most impressive rejuvenation yet reported in adult mammals via a not clearly-described plasma fraction from young animals. DNA methylation clocks significantly rolled back. https://t.co/aCyVZZuLxj

[Regenerative Science @regensci]

The era of milli/micro/nano robots is approaching: Novel living millimeter-scale machines designed by a computer engineered from frog muscle. https://t.co/pNk5RZtby6 https://t.co/Ld9CAEv8OO

[Regenerative Science @regensci]

Looks like DNA repository @addgene raised their prices 66% over their lowest rate--from $45 per plasmid for 21+ ($65 for 1-5, $55 for 6-20 plasmids) to $75 with no volume discount. Too bad they did away with volume discounts. Kudos that they could hold their prices for so long.