"[W]e'll need to redefine what it means to be human. This new definition should focus not on the need for work or productivity but on passions, imagination, and relationships, allowing individual interpretations of humanity." - @vkhosla
Jesse Genet on why AI could reverse fertility rate decline:
"AI will be a dawn of a reversal in that fertility rate decline and will be a golden era for parenthood."
"People want purpose. One of the most meaningful things that humans have gravitated towards, that gives a feeling of a life's purpose, that has been a forever thing, is having kids."
@jessegenet@KTmBoyle@sarahdingwang
Jesse Genet on Agentic Parenting
Jesse Genet joins a16z's Sarah Wang and Katherine Boyle to discuss her journey from founder to parent, how she's using agents in her household, and how AI could transform parenting for the better.
00:00 YC founder turned homeschool mom
03:00 Discovering Claude Code and agentic building
06:00 Building while homeschooling 4 kids under 5
11:00 How AI generates personalized lesson plans and logs progress
18:00 Jesse's 11-agents
27:05 Agent tech stack deep dive
33:56 How agents improve daily life
40:04 Letting kids interact with AI: values, risks, and the future of parenting
@jessegenet@KTmBoyle@sarahdingwang
We’ve raised $27M for this moment: starting today, your agent gets an iPhone and can talk like a friend.
Texting is the universal interface. Billions of people text every day, but until now, developers have been restricted from building on the most powerful channel to ever exist.
Linq is a single API for iMessage, RCS, SMS, voice, and even FaceTime and Find My. Nothing for users to download. Nothing new to learn.
We’re already powering @interaction, @pika_labs, @getlindy, @zocomputer, @joindimension, Tomo (and others we can’t name just yet) to bring this new ecosystem to life.
Join them, and start building for free in our sandbox, linked below. Or comment and we’ll get you set up.
when you’re doing something genuinely new you have no market signal, no comp set, & no validation loop.
the only reliable prior is your own aesthetic judgment. that’s what artists operate on by necessity.
founders at zero should too. e.g. we are a couple of ppl having fuck loads of fun building. like we get a genuine high from this. this effectively turns our office into an opium den.
Huge founder time-wasters
– Conferences (unless you’re speaking)
– constant networking event
– Meeting VCs when you’re not raising
– Entertaining M&A talks when you’re not selling
You’re paid to grow your company, not to network with people who are paid to waste your time.
🇺🇸 U.S. adults: “Ban AI in schools.”
🇨🇳 China: students (and adults) lining up by the thousands to learn OpenClaw.
🚀 Alpha School: our students getting recognized by OpenClaw’s creator @steipete and presenting at ClawCon.
One of them is 15 and has earned $30,000+ in contracts.
American schools are debating whether kids should touch AI.
Our kids are building with it. 🛠️
Focus is probably even more important now than taste
AI will 10x your productivity but it will simultaneously hit you with weapons-grade nerdsnipes that consume 90% of your time
I left a seven-figure job at Goldman Sachs to sell air filters. Everyone told me it was a mistake. Over $1B in sales later, I think the lesson is simple: don't let other people's risk tolerance dictate your life.
Sam Altman on the advice he wish he received when he enrolled in YC in 2005
Y Combinator CEO Garry Tan asks OpenAI founder Sam Altman what he wish knew when he was going through YC back in 2005.
Sam responds:
“I wish someone had taught me the importance of conviction and resilience over a long period of time. People don’t really talk about how hard that is. It’s easy for a little while, but your reserves kind of wear down on it.”
He continues:
“Also just trust that it’s eventually going to work out. Obviously my first startup [Loopt] didn’t work that well. A lot of people give up after one failed startup, but startups don’t workout all the time. Learning how to keep working through that is really important. So is developing trust in your own instincts and increasing that trust as you refine your decision-making instincts over time. Courage to work on stuff that is out of fashion but is what you believe in and care about is also really important.”
Sam recently had a kid and reflects on how everyone will tell you that it’s “the best thing you will ever do, but also the hardest thing you will ever do.” He believes startups are similar:
“The good parts are really great — better than you think. And the hard parts are shockingly much harder than anyone can express in a way that makes any sense to you, and you have to just keep going.”
Video source: @ycombinator (2025)
Running a company is just context engineering internally.
Now that skill has even more value in the agentic world. Us tech founders have been doing reps to prepare for this.
When the typical outcome for a post seed, post series A, and post series B startup is death. Perhaps the best strategy is to be careful how much you copy the startups around you. Are you brave enough to think different?