Dr Rob Leigh

Senior Research Fellow in Bioinformatics & Molecular Epidemiology @TrinityMed1. Adj Asst Prof in Stats @SETUIreland. Interested in omics approaches to medicine

[Bacterial Genomics @BactGenRSS]

A prehistoric East-Asian Yersinia pestis genome and a ~5.3 ka trans-Eurasian expansion of plague https://t.co/yM803RswWM

[Mick Finnegan @Mick_Finnegan]

I'm 1000 days sober today. 😊

In those 1000 days I left Ireland, moved to the Netherlands, started studying International Social Work, and now I’m getting ready to become a father.

Sobriety didn’t just change my habits, it changed my whole life.

#SoberLife #TherapyWorks

[Science Magazine @ScienceMagazine]

In a new Science study, researchers report that specific regions dense in cytosine and guanosine dinucleotides are epigenetically modified during inflammation to enable gene expression and that these changes persist during the animal’s lifetime.

The finding has implications for understanding how the genome determines the longevity of memory, which affects tissue fitness.

Learn more in a new #SciencePerspective: https://t.co/VJwEsaHD5W

[Dr Rob Leigh @RobLeigh_]

@Ben_Scallan They absorb water like little sponges

[Dr Rob Leigh @RobLeigh_]

Completely normal interaction

[Dr Rob Leigh @RobLeigh_]

@NBoydGibbins @amaticahealth This is something bioinformaticians do in the background on a daily basis, is this a particularly rare disease? This is also on 17 patients if I’m not mistaken; unless it’s a rare disease, that sample size is going to constrain you. Has a power analysis been done?

[Dr Rob Leigh @RobLeigh_]

@HelenORahilly Pretend like it’s normal

[Dr Rob Leigh @RobLeigh_]

Grand day for the Parish. Sincere gratitude to @RoseAnnekenny1, @CathalMcCrory1, and the wider @tilda_tcd team for supporting me through this process.

[Dr Rob Leigh @RobLeigh_]

Linezolid resistance, normally vertical and chromosomal is showing up horizontally via mobile elements. Predictable, still consequential

[Wiep Klaas Smits @SmitsLab]

The emergence and biological characteristics of linezolid-resistant Clostridioides difficile isolates in the Asia-Pacific Region https://t.co/AcOzTgM0TY

[Mark Tenenholtz @marktenenholtz]

Python is removing the GIL.

The GIL (Global Interpreter Lock) prevents you from running multi-threaded code.

That makes ML code, in particular, really hard to write in pure Python.

Here's what it takes to remove the GIL:

[Microbiology Society @MicrobioSoc]

🔍Analysis of whooping cough isolates from over 82 years reveals the 'bystander effect' of the pertussis vaccine, affecting the evolution of a non-target species. Valérie Bouchez and Sylvain Brisse take us behind the scenes of their latest publication🔗 https://t.co/S3eolceWj3

[Dr Rob Leigh @RobLeigh_]

@Avimanyu8008 @hamptonism Good explanation. I might be wrong but I think it is 20, not 21.

For 19: P(20)/P(19) = 1.004
For 20: P(21)/P(20) = 0.998
For 21: P(22)/P(21) = 0.996

For this, the idea is to find were the ratio crosses 1. For 19, it’s above 1 and for 20 it’s below 1. Therefore, 20 is optimal

[James Zou @james_y_zou]

Today in @NatureMedicine we report that AI can predict 130 diseases from 1 night of sleep🛌

We trained a foundation model (#SleepFM) on 585K hours of sleep recordings from 65K people—brain, heart, muscle & breathing signals combined.

AI learns the language of sleep🧵

[Jerzy Szablowski @JerzySzablowski]

"In many gene expression studies, cells are extracted by tissue dissociation and fluorescence-activated cell sorting (FACS), but the effect of these protocols on cellular transcriptomes is not well characterized and is often ignored."
https://t.co/B4d2Se7vZy

[Prof. Nikolai Slavov @slavov_n]

How well do mRNA levels predict protein levels in human tissues ?

A simple question confounded by a paradox.

Our @PLOSCompBiol article: https://t.co/NXkHCEqUfK

[Dr Rob Leigh @RobLeigh_]

@Rainmaker1973 Milk, it’ll help with the spice

[Dr Rob Leigh @RobLeigh_]

@ahdam___ Karteng had a PhD in Economic History 👀

[Dr. Dominic Ng @DrDominicNg]

Pets completely protect against mental decline from living alone.

9-year study of 7,945 older adults: People living alone with pets kept their mental sharpness just as well as those living with family.

Your dog or cat might be saving your brain.