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@francoisfleuret https://t.co/wDbvotp0qn

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@Trinhnomics You're either not an American, or simply pussyfooting about the real issue here. Ethnicity/race and culture are highly relevant to academic performance...

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@ErichMSchwarz @lauriewired In 1973 (Version 4 Unix) Ken Thompson and Dennis Ritchie rewrote the Unix kernel primarily in the C programming language, (from PDP-11 assembly language) to make the operating system portable across different hardware. This turned out to be very important...

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@tszzl To avoid an unpleasant scenario, this graph needs to change.

https://t.co/OMSqJOQ6U0

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@teortaxesTex Apple's and Google's moats seem pretty secure. Also, don't take Western Governments propaganda about "free markets" too seriously, if this technology is actually Machine God/Nuclear Weapons grade, it will be brought under state control very quickly...

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@LocasaleLab STEM Graduate Numbers Comparison

China: ~3,570,000 annually (comprising about 40% of all higher education graduates)

United States: ~580,000 annually (comprising roughly 20% of all graduates)

You are seriously misguided about this issue...

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@emollick I certanly agree with Harlan Ellison being at the botom of this particular list!
The Metamorphosis of Prime Intellect by Roger Williams made for fairly unpleasent reading as well. Williams is not near the level of the writers on this list, but he had some interesting ideas.

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@curiouswavefn Hertz's demonstration of electromagnetic waves ranks very high. And I have always had a soft spot for Millikan and Fletcher's Oil drop experiment.

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@omarali50 @snikam India and China were more or less at the the same state of development in 1948, 1949... There are really no excuses for the failures of India's ruling class...

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@omarali50 @snikam In multiracial societies, you don't vote in accordance with your economic interests and social interests, you vote in accordance with your race and religion
Lee Kuan Yew

(Prime Minister of Singapore from June 5, 1959, to November 28, 1990.)

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@NachoOliveras The quote originated from a series of private interviews and strategic discussions that Lee Kuan Yew held with prominent Western scholars and policy experts—specifically Joseph Nye, the former Dean of the Harvard Kennedy School.

[Alex Rives @alexrives]

Today we're announcing ESMFold2, an open scientific engine to power prediction, design, and discovery across protein biology.

The new model delivers state of the art performance on protein interactions, especially antibodies, a critical modality for therapeutics.

We have designed and validated miniprotein binders and single chain antibodies across five therapeutic targets that are important in cancer and immunology. We are seeing very high success rates, and affinities at levels consistent with therapeutic activity.

We’re also releasing an atlas of 6.8 billion proteins, and 1.1 billion predicted structures.

ESMFold2 is built on a state of the art language model that has been trained on billions of protein sequences.

A world model of protein biology emerges through language modeling.

We’ve used the techniques of mechanistic interpretability developed to understand large language models to understand the concepts ESM uses to represent proteins.

The model’s representation space has a compositional organization of features across scales, levels of complexity, and abstraction, that reflects and mirrors the understanding of protein biology developed through a century of empirical science.

This understanding emerges without prior knowledge, just from language modeling of protein sequences.

Language models are becoming a powerful substrate to understand and program biology.

The design of protein interactions is one of the most fundamental problems in biophysics, and has critical implications for the discovery of new medicines. A simple gradient based search with the model was able to discover high-affinity protein binders.

I'm excited by the potential this has to accelerate basic science and the understanding of proteins. And especially for the new avenues it opens up for therapeutic design and medicine.

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@jmrphy https://t.co/KJT3urkh5n

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@tonylfeng @littmath We may need to drill down on exactly what we mean by "conceptual breakthrough" There is an unpleasant non zero possibility that we humans simply sophisticated stochastic parrots

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@tracewoodgrains In a world where Ketanji Brown Jackson is on Scotus, this is a risk worth taking...

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@sislamoglu @jenbegakis @razibkhan I would bet against that for Istanbulites, but yes, that's not the whole country

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@razibkhan https://t.co/D72T9wsBvu

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@HenryYin19 "A new scientific truth does not triumph by convincing its opponents and making them see the light, but rather because its opponents eventually die, and a new generation grows up that is familiar with it."

Max Planck’s Scientific Autobiography (1948)

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@kyleichan @ryanl_hass A piece that does not mention Russia even once, is not serious analysis. Also, one of the sharpest divsions between Europe and the United States, is differing value assements of Taiwan vs Ukraine