Roozbeh Eskandari

Staff Scientist @EinsteinMed | Enzymes | Metabolites | Site specific isotope enrichment | Metabolic Flux | Transition state analogs |

[Science Immunology @SciImmunology]

New in Science #immunology: NAD+ is at the center of a metabolic and epigenetic pathway that establishes trained immunity in macrophages, mouse models show. https://t.co/bR2px7ePC8

[Cell Host & Microbe @cellhostmicrobe]

Microbial products trigger chemosensory dialogues via GPCRs

Libraries of gut metabolites+GPCR-seq reveal how gut senses environmental chemicals. ID microbial products activating specific receptors, including those triggering serotonin or linking to IBD
https://t.co/VXHfeFjrTR

[Ahmad A. Cluntun @molecularpepsi]

Folks, despite my best efforts, I regret to announce that I have published a paper in @Nature.

I can finally become one of those annoying PIs who tells trainees they don’t need a Nature paper to get a faculty job.

#blessed @mbeisen

https://t.co/ylAF8M9EBD

[nature @Nature]

Nature research paper: Cold activates a BH2 metabolic network promoting longevity and proteostasis

https://t.co/qd1xEOA0GN

[Roozbeh Eskandari @roeskandari]

Congrats to Celine Taglang, PhD, et al., for demonstrating that diethyl [3,3′-2H2]-α-KG is a powerful deuterium probe for monitoring early response to vorasidenib and distinguishing sensitive from resistant tumors. This work identified PHGDH as a novel vulnerability in glioma👇

[Cancer Research @CR_AACR]

Now online: PHGDH Sustains Oncometabolite Production to Drive Resistance to Mutant IDH Inhibition in Glioma that can be Monitored by Metabolic Imaging https://t.co/bd9QBg2X9s

[David Vilchez @TheVilchezLab]

1/6 ❄️ Very happy to share our new study: “Cold activates a BH2 metabolic network promoting longevity and proteostasis.”
https://t.co/63BQK6AHUh
#Aging #Longevity #Proteostasis #Metabolism #ALS #HuntingtonsDisease

[Cell @CellCellPress]

Now online! Mitochondrial ATP promotes T cell differentiation through chromatin accessibility https://t.co/aHXNkCdcL1

[Molecular Cell @MolecularCell]

Online Now: Nicotinamide nucleotide transhydrogenase directly couples redox homeostasis to proline biosynthesis in human glioma https://t.co/TJGMPsZNqs

[Roozbeh Eskandari @roeskandari]

PFK allostery works by reweighting the conformational ensemble, not a discrete R↔T switch. This study shows that activator and inhibitor binding to the same allosteric pocket shift the ensemble in opposite directions, extending prior kinetic discoveries to the atomic level.👇

[J. Am. Chem. Soc. @J_A_C_S]

Bidirectional Allosteric
Ligand Regulation in a Central
Glycolytic Enzyme https://t.co/7Ap5q2JU04

[Shilatifard Lab @ShilatifardLab]

Congratulations to Chandel lab for demonstrating that a metabolite once considered purely “toxic” may actually be a key signaling molecule in cells and organisms. This study demonstrates that l-2-HG functions in signaling by regulating epigenetic state via KDM4/H3K9me3 demethylase and linking redox state to transcriptional repression. The study provides initial words in “Metabolic Language” of transcription. https://t.co/VGUTYlhsk3 @NU_BMG_SQE @NUFeinbergMed @Nature @CellPressNews @ScienceMagazine @MolecularCell @theNASciences @theNAMedicine @NorthwesternU @NatMetabolism

[Roozbeh Eskandari @roeskandari]

Multiplexing HP-MRS probes measures RAS-related AP activities in tumor-bearing mice, and evaluates the efficacy of antiangiogenic therapies in early stages👇

[J. Am. Chem. Soc. @J_A_C_S]

In Vivo Multiplexed Analysis of Aminopeptidase Activities by Hyperpolarized Molecular Probes for Tumor Diagnostic Applications | Journal of the American Chemical Society https://t.co/D8MIPuafRQ

[nature @Nature]

Nature research paper: Catabolism of extracellular glutathione supplies cysteine to support tumours

https://t.co/gjUovoKxqu

[Isha Jain @ishahjain]

A century ago, “vitamin hunters” discovered micronutrients. Today, vitamins are taken adhoc. We revisited this with modern genetics: CRISPR screens -> new NAXD disease mouse -> over 40× lifespan increase w/ vitamin B3. Huge credit to Ankur & Skyler! https://t.co/0cRmrng7ux
🧵👇

[Nature Metabolism @NatMetabolism]

A genetically encoded bifunctional enzyme mitigates redox imbalance and lipotoxicity https://t.co/T0VWNdxPun

[Eric Topol @EricTopol]

How does obesity lead to immune system dysregulation and chronic inflammation?
Macrophage metabolism is rewired, with activation of the NLRP3 inflammasome @ScienceMagazine https://t.co/bkAUgOE1c2

[Nature Metabolism @NatMetabolism]

The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans https://t.co/6nsBQNlOGu

[Baharan Meghdadi @BaharanMeghdadi]

Excited to share that our digital twin framework predicting patient responses to metabolic therapies is now published online @Cell_Metabolism. One step forward to personalizing glioblastoma treatment. Thankful to my advisors @DNagrathLab @DanWahlMD https://t.co/irey5ZZxw4

[Molecular Cell @MolecularCell]

Online Now: Accumulation of succinate suppresses de novo purine synthesis through succinylation-mediated control of the mitochondrial folate cycle https://t.co/vt6aogqM0V

[J. Am. Chem. Soc. @J_A_C_S]

Methionine Salvage Enzyme Uses a Unique Mechanism to Overcome a Challenging Aldose–Ketose Isomerization | Journal of the American Chemical Society https://t.co/dcKFQdPlUK

[Cell @CellCellPress]

Now online! SARM1 senses dsDNA to promote NAD+ degradation and cell death https://t.co/Cj81DEe8IX