Our new co-first-author paper is out in Nucleic Acids Research!
We unexpectedly found that nascent-chain sequences located well upstream of P2A—even outside the ribosomal exit tunnel—can modulate peptide-bond skipping efficiency. 1/n
https://t.co/sg1cAN9uAc
Fresh out of the press @Dev_Cell! w Z. Smith @YaleGenetics and B. Law & M. Chan @Princeton we engineer a high-content molecular recorder to reconstruct thousands of cell lineages during embryoid morphogenesis. #MeissnerLab@MPI_MolGen. A🧵(1/14)
https://t.co/W4KEqZrE3c
Publication alert ! Paper from https://t.co/tINPtwkZSL in @Nature
How complex epigenetic modification signatures regulate genome function. With interactive online resource https://t.co/2pY8dpU51l Big data ! @epigeneticsHMGU@HelmholtzMunich
https://t.co/pbuGbsevF8
Excited to share the second piece of my PhD work! Our paper on generating 2D and 3D spatial transcriptomic maps of whole mouse embryos during early organogenesis with @adrianobolondi@Luyi_T is out in @NatureGenet 🐭🧬 @MPI_MolGen@broadinstitute.
https://t.co/Bz7vDWeAag
.@GemmaNoviello report CasTuner for analog tuning of endogenous gene expression and show homogeneous gene expression tuning across mouse and human cells
#BiotechNatureComms
https://t.co/GIyLdTC2vP
Many proteins bind RNA, yet we still don’t know what RNAs most RBPs bind because current methods map one protein at a time. With the Jovanovic lab, we describe SPIDR – a method for mapping the RNA binding sites of dozens of RBPs in a single experiment. https://t.co/BnxlSyJLfE
#CasTuner has been published on @NatureComms last week. I wrote a blog post to explain what this stuff was about if you get bored reading an entire paper or don't have time to do it: https://t.co/9zrqjjNqXi
Ever wondered how the peculiar placental epigenome is regulated? We discovered a dynamic DNMT3B/Polycomb-antagonism that maintains it! Beyond thrilled to share my PhD work together with @hetzel_s published @NatureCellBiology. @MPI_MolGen#MeissnerLab (1/9) https://t.co/x5vjLyQUHe
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I am happy to share that my PhD work on predicting protein-protein interactions using intrinsically disordered regions is now published in Proteins : Structure, Function, and Bioinformatics ! @VingronLab
https://t.co/GA3gjphc1U
#PPIs#IntrinsicallyDisorderedRegions#IDPs
Ever wished to tune endogenous gene expression @ single cell level? Now you can! With #CasTuner : a degron and CRISPR/Cas-based toolkit for analogue tuning of endogenous gene expression. New preprint out! With @EddaGSchulz@RutgerGjaltema@MPI_MolGen https://t.co/1FLji44Za1
This week's #FluorescenceFriday user is @AbhiSampKumar! Abhishek uses #HCRimaging to validate and map expression patterns of multiple genes in whole-mouse embryos. "Whole-mount embryo RNA-FISH has been possible only with HCR." View his work here: https://t.co/fIkD481gBE
Our collaborative work with @zhejliu and @TjianDarzacq is now published in Nat Genet. Huge thanks to @549nm and @Yifeng_QI for their years of effort!
https://t.co/uh4tavD5Qv
My groups first Pre-print is now out on Sneak Peak! Interested in how chromatin is compacted into chromosomes, the players involved and the mechanism of how they do it? Check out our Sneak Peak. Congratulations to all that were involved https://t.co/uDqlZ3mi1u
🧬 How is #chromatin compacted into chromosomes? Our Kinkley Lab identified polymer-polymer phase separation (PPPS) as underlying mechanism of higher chromatin order transitions, found involved factors & provides 1st in-vivo evidence!
📎 #Preprint here:
https://t.co/Lt2tKzb8Ar