Wilfried Rossoll

translational Neuroproteomics Lab | We study protein (dis)aggregation in ALS/FTD, AD, and other neurodegenerative proteinopathies. (Views are my own.)

[Wilfried Rossoll @RossollLab]

We’re hiring! Two postdoc positions are open in the Translational Neuroproteomics lab at Mayo Clinic Florida, focusing on tau and TDP-43 proteinopathies and neurodegeneration.
https://t.co/VMHHFmD0bI
Apply here:
1) https://t.co/vfoLJ7I0om
2) https://t.co/D1PW1bZSiA
Please share!

[Wilfried Rossoll @RossollLab]

It is truly a great honor to be selected as a 2025 Kissick Family Foundation Frontotemporal Dementia (FTD) grantee. I extend my heartfelt gratitude to the Kissick Family Foundation in partnership with @MIPhilanthropy for their support.
https://t.co/xG2OPsmG33

[The Rainwater Charitable Foundation @RCFNeuro]

In partnership with @aging_mind, @alzassociation, and @CurePSP we recently hosted the 2025 #TauopathyChallengeWorkshop and are excited to announce the grantees who will receive a total of $2.5 million in funding to advance their neurodegenerative research: https://t.co/nSFWYNE0jP

[Wilfried Rossoll @RossollLab]

It’s truly an honor to be selected as a 2025 #TauopathyChallengeWorkshop grantee. I extend my heartfelt gratitude to the @RCFNeuro, @aging_mind, @alzassociation, and @CurePSP for recognizing the potential impact of our work how TDP-43 co-pathology affects tauopathies.

[Wilfried Rossoll @RossollLab]

Our study provides a first comprehensive overview of pTau-associated proteomes across tauopathies and uncovered several important findings. It is also a starting point for further ProPPr projects, where we can put to good use everything that we have learned during this journey.

[Wilfried Rossoll @RossollLab]

https://t.co/gYUWBuQC1B
Out now! Probe‑dependent Proximity Profiling (ProPPr) of Phospho‑Tau‑Associated Proteomes across Tauopathies by @DMorderer and @NeuroWren. Great collaboration with @DrNeuroChic and Dr. Dennis Dickson! @MayoClinicNeuro @MolNeuro @cziscience @NIHAging

[Wilfried Rossoll @RossollLab]

Our analysis demonstrated that infiltration of APs with FTL-positive microglia is a characteristic feature of CBD pathology. The observed complex co-localization patterns underscore the importance of using fluorescence microscopy to follow up on proximity proteomics findings.

[Matthew Taliaferro @JMTali]

Excited to share our latest work! We asked if and how TDP-43 regulates RNA transport in neurons and if this is misregulated in ALS. We found that it works to keep RNAs *out* of neurites, and that loss of TDP-43 activity results in specific RNAs aberrantly accumulating there.

[Matthias Mann Lab @labs_mann]

Introducing mipDVP (multiplexed imaging-powered Deep Visual Proteomics)! Using 22-marker imaging to profile proteomes across hot/cold tumors, revealing immune microenvironments, macrophage barriers to T cells, & hypoxic adaptations. Out in @MolecularCell
https://t.co/bdlx8M23Y0

[David Katz @Katz_Lab]

If Nature and Science journals both agree on this, surely there is at least a 60% chance it is true. https://t.co/3RB9oCUmUG

[Wilfried Rossoll @RossollLab]

Looks like PPS Silent Surfactant, Progenta anionic acid labile surfactant (AALS) I, AALS II, cationic acid labile surfactant (CALS) I, and CALS II are not commercially available anymore.

[Wilfried Rossoll @RossollLab]

Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.

[Wilfried Rossoll @RossollLab]

Can someone please point us to a source for mass spectrometry compatible surfactants less pricey than Invitrosol, ProteaseMax, and RapiGest SF? DDM did not work that well in our hands for FFPE tissue extraction and proteomics.

[Matthew Taliaferro @JMTali]

Excited to share our latest work! We developed a new method for studying RNA localization via proximity labeling: OINC-seq! In contrast to other proximity methods, labels deposited on RNAs are read directly by sequencing without a need for biotinylation. https://t.co/SPvrMuw4ld