Ryan Henrici

VP Discovery Medicine @BigHatBio // Global Health Scholar & Adjunct Professor @PennMedicine

RT are not endorsements. View are entirely my own.

[Ryan Henrici @ryan_henrici]

@bots_and_bits Human clinical data, maybe. For ML models of drug design, this approach doesn't work. Data has to be collected in a standardized fashion to generalize well. There's too much noise in data across different labs and protocols to train meaningfully predictive models.

[Ryan Henrici @ryan_henrici]

Excited to share this important work from my team. Artemisinin is the cornerstone of malaria control worldwide. We provide the first report of partial resistance in African patients with complicated malaria, a harbinger of a looming public health emergency on the continent.

[JAMA @JAMA_current]

Artemisinin resistance, linked to K13 protein variants, found in Ugandan children with complicated malaria. Suboptimal efficacy observed for standard artesunate-based treatment.

https://t.co/o1XNRjOh8W

[Ryan Henrici @ryan_henrici]

@ronalfa You should check out BigHat Biosciences. We combined synbio and ML tools to reduce bio “latency”. Models propose new antibody designs, we express them individually, measure properties, and retrain. Tons of molecules, every week, across projects. Scaled lab feedback is essential.

[AbbVie @abbvie]

NEWS: We’ve entered a research collaboration with @BigHatBio to leverage #ArtificialIntelligence and #MachineLearning to develop next-generation therapeutic antibodies in oncology and neuroscience. Explore: https://t.co/eeHaC37Q3q

[Ryan Henrici @ryan_henrici]

I'm super excited for my group @BigHatBio to join forces with the team at @abbvie oncology research to develop new antibody medicines. Their scientists have been so smart, open, & fun during project planning - can't wait for the world to see what's coming.
https://t.co/AHnz3BcmK9

[BigHat Biosciences @BigHatBio]

📽️Exciting News! BigHat Biosciences is thrilled to unveil our new BigHat teaser trailer. Take a behind-the-scenes look at who we are and what we're passionate about.

🧬Join us on this journey of making better therapeutics faster.

Watch the video here: https://t.co/OMXjLL12Vr

[Ryan Henrici @ryan_henrici]

@robertomunita @Nicolas6901 Great minds think alike! Based on how much of a pain it was to make these (exact sizing, nesting & assembling the inserts, redesigning some fragments to ensure true-to-size migration on polyacrylamide and agarose gels) I’m glad we could save you the effort 🙂 happy gel running!

[Ryan Henrici @ryan_henrici]

@robertomunita @Nicolas6901 So glad you like our ladders and find they work well! Commercial pre-made ladders are convenient, but the costs over time are not insignificant, which is exactly why we made these plasmids. I’d love to know how you discovered them!

[Dr. Andrea Conroy, PhD (she/her) @AndreaLConroy]

We are starting to see malaria parasites emerge that are not recognized by PfRDTs and have molecular signatures of drug resistance. T if malariake home📌a is suspected but RDT negative, do a blood smear or use RDTs that identify different antigens (LDH)
https://t.co/8u7OOhU7qI

[BigHat Biosciences @BigHatBio]

BigHat’s Sr. Director of Translational Research, Dr. @ryan_henrici, will give his invited talk, AI for Biologics Discovery, Optimization, and Development, at the 27th Charles River Biotech Symposium held on Sept. 11–13 in La Jolla, CA.

To register: https://t.co/28J5042okG

[Dr. Glaucomflecken @DGlaucomflecken]

Infectious disease goes on a hike

[Ryan Henrici @ryan_henrici]

@PWB_Global thanks for sending me a copy of your text! This is an incredible resource for clinicians, trainees and educators. Looking forward to teaching from it this fall at @PennMedicine!

[Ryan Henrici @ryan_henrici]

@RossWaller3 Agreed. David was a frequent member of our LSHTM lab meetings and regularly brought humour and razor sharp intellect - sorely missed! He and Lawrence Bannister were among the first to see some of our work on clathrin-free endocytosis in Plasmodium

[Ryan Henrici @ryan_henrici]

@RossWaller3 @RossWaller3 Fantastic work! Flagging these SIM images I took in Plasmodium that strongly agree with the biology and images your group show in Fig 1. These orthogonal studies are essential to unraveling the complex biology of these nasty but gorgeous organisms.

[Dr. Glaucomflecken @DGlaucomflecken]

Don’t say I didn’t warn you

[Ulrich Schwarz (also @ulrichschwarz.bsky.social) @SchwarzUlrich]

Spectacular discovery by @FrischknechtLab: #malaria #sporozoites form rotating vortices. Our theoretical analysis, now published in @NaturePhysics and led by @pintupatra05, identified the key physical aspects: self-propulsion, curved shape, chirality and mechanical flexibility

[NEJM @NEJM]

I know that I'm dying, and you know that I am dying. You can hide behind behind your prim white coat, but I see you and I demand that you behold me. https://t.co/cPOwyINp3s

[BigHat Biosciences @BigHatBio]

We are excited to announce that BigHat published its first peer-reviewed article in collaboration with Bayesian deep learning expert, @andrewgwils at the prestigious @icmlconf Workshop on Computational Biology.

https://t.co/pVaEOZhTKU

[@EPPIcenter at UCSF @EPPIcenter_UCSF]

Decreased parasite burden & altered host response in children w/ sickle cell anemia & severe anemia w/ malaria
@ryan_henrici @Casey_Sautter Caitlin Bond @robert_opoka @RNamazzi Dibya Datta, Russ Ware @AndreaLConroy @ChandyJohnLab @MakSPH @healinitiative
https://t.co/sGMa3IZQWy