Sadie Antine

PhD Candidate @VirologyHarvard @DanaFarber Kranzusch Lab anti-phage defense, X-ray crystallography, cryo-EM | @BrandeisU alum @sadieantine.bsky.social

[Sadie Antine @sadie_antine]

Out now @Nature we report the structural basis of Gabija defense and how the anti-defense phage protein Gad1 wraps around Gabija in an octameric web for immune evasion! 🐙🕸

https://t.co/GA2VQVYbC3

#b3d #MolecularNodes @bradyajohnston

[Sadie Antine @sadie_antine]

@apbrogan Thank you!!

[Sadie Antine @sadie_antine]

Happy Halloween!👻

[Sorek Lab @SorekLab]

We discovered a new immune signaling molecule: N7-cADPR

N7-cADPR is produced by phage-stimulated TIR proteins. It activates a bacterial caspase, which then degrades essential proteins to curb infection

Preprint: https://t.co/0dzoyNP6t5

Congrats @FrancoisRousset & @IlyaOsterman

[Smita Gopinath @SmitaGopinath]

Excited to announce the first paper from our lab identifying a family of anti-inflammatory compounds from vaginal lactobacilli #microbiome #WomensHealth https://t.co/pqTXY4TtsV (1/8)

[Aude Bernheim @AudeBer]

Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬.

Excited to welcome these amazing speakers at @institutpasteur .

Registration will open beginning of November. Abstract deadline February 28. Stay tuned.

[Sadie Antine @sadie_antine]

@lindsey__young Congrats Lindsey!!

[Sadie Antine @sadie_antine]

@yisak_w @mbiojournal Congrats!!

[Sadie Antine @sadie_antine]

@morehouse_ben Congrats Ben!!

[Sadie Antine @sadie_antine]

@JanyBinovsky Congrats Jan!!

[Jan Binovsky @JanyBinovsky]

🚀Announcing my first (co)first-author manuscript 🚀

"Cell attachment and tail contraction of S. aureus phage phi812"
🔗https://t.co/u26fawQZqJ

Check out the 🧵 to explore the structural details of phage interaction with Gram+ bacteria🤯

#PhageTherapy #Research #PhDlife

1/11

[Sadie Antine @sadie_antine]

@wanyuviridae Huge

[Alexander Harms @AHarms485]

Preprint alert 🚨! I present you the second and final manuscript on the BASEL phages! 36 new deeply characterized phages from viral groups that were so far mostly terra incognita - and all infect the E. coli K12 lab strain with easy tricks. 1/12
https://t.co/lqZdYvMkSG

[Sadie Antine @sadie_antine]

Soooo incredibly excited for you Shira!

[Shira Weingarten-Gabbay @WeingartenShira]

I'm delighted to share that I will be joining the Department of Microbiology at @harvardmed in January 2025. The Laboratory of Systems Virology will study the dark proteome of viral genomes to understand how viruses work their magic🪄 Thrilled to be back in beautiful Boston 🌟

[@AbrahamLabHMS @abrahamlabhms]

Perhaps one of the coolest experiences I've had as a scientist to hear @abrahamlabhms @wanyuviridae paper on western equine encephalitis virus featured on TWiV! "Heartbeats and hoofbeats" Thank you at @profvrr! (starts at about 51 min) ❤️🐎@HarvardMicro
https://t.co/LvxFyJSJw7

[Harvard Micro @HarvardMicro]

A new paper from Sam Hobbs in the Kranzusch lab (https://t.co/VJl5ID0qcA) demonstrates that animal and bacterial viruses use conserved strategies to defeat host antiviral immunity @CellCellPress
https://t.co/wS6oxb6EkC

[@AbrahamLabHMS @abrahamlabhms]

Sharing a piece on Triple E🦟. I am fascinated by this deadly virus so we do a lot of work on it in the lab. It's quite a nasty bug - for those who live in regions with activity, need to take appropriate precautions re: mosquitoes. @HarvardMicro

https://t.co/XfK5JXSluG

[Sorek Lab @SorekLab]

Tricking phages with reverse transcription

@IlyaOsterman summarized the beautiful discoveries from the labs of @SternbergLab and @zhangf, who showed how bacteria defend against phages by expressing a protein that is not really encoded in their DNA

https://t.co/tsUtHAGhpJ

[Sadie Antine @sadie_antine]

🤯🤯🤯🤯

[Max Wilkinson @maxewilkinson]

My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.

(👇 I recommend sound ON for the video 🎹)
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