Saeed

Science enthusiast; Doctoral Student at KU Leuven, Belgium. Alumnus of @tvmiiser. @LFC fan

[Saeed @saeedfc]

Finally out! The second part of my PhD, a study on fiobrostenosis in Crohn's disease co-lead with @kebojun . Read on the thread for a summary.

[Gianluca Matteoli @gmatteoli1978]

Our study "Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease" is out https://t.co/NgN8TIW530 with first authors @kebojun and @saeedfc in collaboration with @SeverineVermei1 and the @ibdleuven team

[IBD Leuven @ibdleuven]

Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in @CD, a fantastic collaboration with @gmatteoli1978 with first authors
@kebojun @saeedfc now in @jclinicalinvest
https://t.co/B1qxxZYfQF @SeverineVermei1

[Saeed @saeedfc]

As we say in India, a 'double Dhamaka' from Mucosal Immunology Lab. Super happy to be part of this study co-lead by the amazing @LiesvanBaarle @VeronicaDeSimone alongside
@LindaSchneider from @UniBonn

[Gianluca Matteoli @gmatteoli1978]

Excited to announce our latest article on enteric glia-macrophage communication in colorectal cancer (CRC) now published in @NatureComms! https://t.co/zv5sJeCcn3

[Gianluca Matteoli @gmatteoli1978]

Excited to announce our latest article on enteric glia-macrophage communication in colorectal cancer (CRC) now published in @NatureComms! https://t.co/zv5sJeCcn3

[Gianluca Matteoli @gmatteoli1978]

Our study "Intercellular interaction between FAP+ fibroblasts and CD150+ inflammatory monocytes mediates fibrostenosis in Crohn’s disease" is out https://t.co/NgN8TIW530 with first authors @kebojun and @saeedfc in collaboration with @SeverineVermei1 and the @ibdleuven team

[Saeed @saeedfc]

Exciting news!! IBD Leuven @ibdleuven , @gmatteoli1978 and @BoeckxstaensLab , has secured a $2.8m grant from @HelmsleyTrust for a collaborative study on the origin of fibrosis in Crohn's disease. https://t.co/B4p0lK6QMi @bverstockt @SeverineVermei1

[IBD Leuven @ibdleuven]

It’s truly a pleasure hosting this week #Victoria #Gudiño from the @AzucenaSalas17 lab @ibd_bcn giving an excellent talk today at our weekly labmeeting! #unmetneeds #perianalCD @gmatteoli1978 @fibrotarget @HelmsleyTrust

[Saeed @saeedfc]

A massive thanks to the jury members @RajaAtreya @YvanSaeys @LabMazzone @bernthie for their time and effort to evaluate the thesis.

[Saeed @saeedfc]

Broke through the PhD finish line 👨‍🎓 Immense gratitude to my promoter @gmatteoli1978 & co-promoter @bverstockt, & to my team at the Mucosal Immunology lab @TARGID_KULEUVEN. You've made the road worthwhile.🙏

[Lisa Sikkema @SikkemaLisa]

Today our Human Lung Cell Atlas (HLCA) paper came out in Nature Medicine https://t.co/PAb5zP53p5! The HLCA includes 2.4M cells from 486 individuals and 49 datasets. Check out this tweetorial to learn more about how we built it, and how you can use it (1/21)

[Gianluca Matteoli @gmatteoli1978]

Our new article, "IL-1R signaling drives enteric glia-macrophage interaction in colorectal cancer progression" is now available as preprint https://t.co/hkVrRdE3YK fantastic collaboration between our lab @gmatteoli1978
@TARGID_KULEUVEN and the lab of @ProfSvenWehner @UniBonn

[Preprint Club - Immunology @preprintclub]

📚For Tomorrow's #JournalClub Tapas Mukherjee @ImmunologyUofT will present a #preprint by @gmatteoli1978 @SeverineVermei1 labs on how CD150 monocytes promote tissue fibrosis by inducing the differentiation of FAP fibroblasts in Crohn’s disease patients💥👇
https://t.co/aGGRZZ1YAr

[Saeed @saeedfc]

@mariaelemartino @rafeequemavoor

[Seb @ibdseb]

Really nice study - progress in an area of unmet need in #IBD

[Anissa @AnissaZouzaf]

Go check it out 👇🏼🤩

[IBD Leuven @ibdleuven]

Another #DDW2023 poster session round today! Proud of the entire team presenting their research today, disseminating with the #IBD field! #IDeGreef #LFierens @SeverineVermei1 @JoaoPGSabino @bverstockt #MFerrante @HelmsleyTrust @TARGID_KULEUVEN

[IBD Leuven @ibdleuven]

Taking a deep dive into the mystery of #fibrostricturing #CD! Big collaborative effort with @gmatteoli1978 @saeedfc @kebojun and many other collaborators! @SeverineVermei1 @bverstockt @SareVerstockt @DhooreAndre @bisle84 @FWOVlaanderen @TARGID_KULEUVEN @HelmsleyTrust

[Gianluca Matteoli @gmatteoli1978]

Our study sheds light on fibrostenotic #CrohnsDisease! Together with @ibdleuven we uncover pro-fibrotic signals from CD150-monocytes, leading to a specific fibroblast population causing inflammation & tissue fibrosis. Follow our @fibrotarget @HorizonEU consortium for new update

[Saeed @saeedfc]

🧪 Led by @kebojun & @saeedfc in an extensive collaboration between @gmatteoli1978's Mucosal Immunology lab & IBD Leuven (@Severine, @ibdleuven) at @TARGID_KULEUVEN, with crucial contributions from other collaborators. #IBDResearch #Inflammation #Fibrosis (3/3)

[Saeed @saeedfc]

New pre-print!! We analyzed a triad of lesions from fibrostenotic #CrohnsDisease patients (non-inflamed, inflamed & stenotic) & non-CD patients using scRNAseq. https://t.co/EPFNHVc6hG
#CD #IBD #inflammation
🧬 Key findings below.

[Saeed @saeedfc]

1. Inflammatory monocytes activate a specific pathogenic ECMhi fibroblast population during inflammation.
2. TWIST1 is a crucial modulator of fibroblast activation & ECM production.