Scott Tyler (@[email protected])

Developing new single cell omics methods and bench validating all the hypotheses those techniques give us. Opinions expressed are my own.

[Scott Tyler (@[email protected]) @ScienceScottT]

Working with multiple scRNAseq batches? Having trouble replicating at the bench? Our recent pre-print may show one reason why: (https://t.co/pklPFadpll) Findings complementary to @lpachter & Tara’s work finding low dim projections can be unreliable representations.

[Retraction Watch @RetractionWatch]

Announcing the Elisabeth Bik Science Integrity Fund.
https://t.co/TB0PdDLBWM

[Joao Pereira @jdpereira]

The US mostly funds biomedical research through a large lump payment to the NIH. Panels of scientists and doctors volunteer to decide on the merit of grant individual applications, not unlike a really boring battle royale.

All of this is halted.

No new science is being funded.

[Prof. Nikolai Slavov @slavov_n]

NIH has stopped considering new grant applications, delaying decisions about how to spend millions of dollars.

The freeze occurred because the Trump administration has blocked the NIH…

https://t.co/YX2AxyfdDE

[Prof. Nikolai Slavov @slavov_n]

Some papers seem to be written by authors who did not really know what they wanted to say, and they did not figure it out in the writing process.

[Michael 英泉 Eisen @mbeisen]

This by @SGRodriques laments the (anticipated) failure of models trained on large datasets to reproduce "real biology discoveries" like those found in Science and Nature. While he sees this as a problem, I COULD NOT DISAGREE MORE. That foundational models don't (and God help us won't) spit out Nature papers is a feature, not a bug!

[mgostIH @mgostIH]

Wtf is up with deep learning???

[Scott Tyler (@[email protected]) @ScienceScottT]

@wasserstein_rao Fair enough haha - cloud lab would have a near infinite number of edge cases. I like the idea of starting out with an API, especially if you have it with some validated protocols for RAG. Would be a really cool prototyping even if cloud lab is a bit more distant.

[Alec Stapp @AlecStapp]

It's bad that the NIH has pretty much stopped funding young scientists to lead projects

[Gennady Gorin @GorinGennady]

Single-cell RNA sequencing is biased (and more so if you count more molecules). But biases aren't just arbitrary artifacts; they reveal something non-obvious about the technology and chemistry of sequencing, and we can learn a lot by using physical models. Read to find out more!

[Cell Press @CellPressNews]

Length biases in single-cell RNA sequencing of pre-mRNA. Check out this research by @lpachter & @GorinGennady in @BiophysReports #CellBio2024 https://t.co/5YUur6x9l7

[sina @sinabooeshaghi]

If you’re frustrated with healthcare, get this:

Health Insurance @ElevanceHealth (formerly Anthem) bamboozled @Caltech into overpaying thousands per person for a pricier plan identical to the cheaper one—except for a higher premium and deductible.

No added benefits.

[@jhelisseeff @JHElisseeff]

Seeing data on macrophages and metabolism from single cell. It's somewhat buried in the paper and not obvious from the title - but we see different metabolic profiles in macrophages from pro-regenerative vs fibrotic materials in vivo! https://t.co/nFSy30FxPr

[Scott Tyler (@[email protected]) @ScienceScottT]

@RahulBanerjeeMD @szusmani @sridevirajeeve @CarlynRTanMD @MalinHultcrantz @GunjanLShah @UrviShahMD @MSKCancerCenter Is there a pre-print out yet? =)

[Scott Tyler (@[email protected]) @ScienceScottT]

@iScienceLuvr I'm sure they'll be improving it in chunks with the interactive user feedback RLHF, but it's definitely been a bit of a challenge out of the gate imho

[Scott Tyler (@[email protected]) @ScienceScottT]

@iScienceLuvr Curious what your take on full o1 is at the moment. I've only had one session with it, trying to use it to create a new agent framework & it was really almost unusable for me because it refused to answer, or just said nothing after "finished thinking" so many times.

[Itai Yanai @ItaiYanai]

Data can be analyzed in endless ways, as this paper reminds us. So while our published paper reports one way to do it, it's crucial to test many many variants of the analysis to see just how robust our conclusions are.

[National Human Genome Research Institute @genome_gov]

Happy Thanksgiving! We are thankful for the opportunity to talk about how cool genomics is with you all the time. Our family might get annoyed at us for talking about it too much, but that won’t stop us!

[Scott Tyler (@[email protected]) @ScienceScottT]

It's a weird and beautiful bag of cheetos ;-) Cool technique! Worth checking out the paper; lots of cool new science can be done with this resolution in living systems!

[Eric Betzig @Eric_Betzig]

Relationship between chromosomes (orange) and the mitotic spindle (green) in four stages of cell division, as seen by Bessel Beam plane structured illumination microscopy https://t.co/Z5NRQOoi4q

[Elisabeth Bik @MicrobiomDigest]

Our group of #ImageForensics experts @Thatsregrettab1 , @mumumouse2, @schrag_matthew, and myself are currently posting the problems we found in these papers.
We have now posted 118 of Dr. Masliah's paper onto @PubPeer. Follow our progress here:
https://t.co/ZakEoHHcjw