Steve DeAngelo

UMich 5th year PhD Student @shahlab @umichmedicine. Studying mechanisms of oxidative stress regulation in #coloncancer

[Steve DeAngelo @SDeangelo95]

Thrilled to share that my thesis work on #ferroptosis is now live on @biorxivpreprint!

Here in the @YatrikShahLab we show that RSL3 is a non-selective inhibitor of the Selenoproteome, revealing new therapeutic opportunities in #colorectalcancer

https://t.co/6xuxGlTDvM

[Steve DeAngelo @SDeangelo95]

@ThornSesholdLab @Linkermann_Lab @YatrikShahLab Super cool study! Honestly not surprising at all that chloroacetamides have so many off targets. We think this is why RSL3 is so effective compared to 2nd gen GPx4 inhibitors - just like with some kinase inhibitors it may be effective because it’s non specific

[Steve DeAngelo @SDeangelo95]

@ThornSesholdLab @Linkermann_Lab @YatrikShahLab @ThornSesholdLab good catch! PDIs were one of our top enriched protein classes after thioredoxin peroxidases and selenoproteins. Happy to chat if you want to dig into the data more!

[Steve DeAngelo @SDeangelo95]

@SGIMuscle @Linkermann_Lab @YatrikShahLab @SGIMuscle Depends on the context! For GPx4 inhibition - definitely. But for induction of ferroptosis the lack of specificity from RSL3 may be what drives its potency. But JKE1674 from @SchreiberStuart lab is even better than ML210

[Steve DeAngelo @SDeangelo95]

@jaybradner @JunQiLab Just sent, check your gmail! Feel free to spread the news for anyone interested in updates in ferroptosis and colon cancer!

[Steve DeAngelo @SDeangelo95]

Always great catching up with @JunQiLab! Two @jaybradner lab alums staying excited about science!

[Steve DeAngelo @SDeangelo95]

@jaybradner @JunQiLab Tune in for the thesis defense! May 10 at 2pm, I can send over the zoom link!

[Steve DeAngelo @SDeangelo95]

You know you’re back in Boston when you pass not one, not two, but three separate Dunkin’ Donuts just on the walk to the Logan Airport baggage claim

[Steve DeAngelo @SDeangelo95]

@LyssiotisLab @PancanMonica @YatrikShahLab Thanks for the shoutout @LyssiotisLab! We show that RSL3 is so potent in CRC *because* it’s a remarkably dirty Selenoprotein inhibitor, as we found a CRC cell line that’s sensitive to RSL3 but insensitive to GPx4 KD!

[bioRxiv Cancer Bio @biorxiv_cancer]

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer https://t.co/IKG6GR5TKG #biorxiv_cancer

[bioRxiv @biorxivpreprint]

Recharacterization of RSL3 reveals that the selenoproteome is a druggable target in colorectal cancer https://t.co/lLCH592QMr #bioRxiv

[Steve DeAngelo @SDeangelo95]

Excited to share our review article on the roles of Selenoproteins in Cancer!

These selenocysteine containing proteins are emerging as regulators of oxidative stress and redox regulation in many cancers
@trendscancer @CellCellPress @YatrikShahLab

https://t.co/PsQ1RmhX6c