Sellegounder Durai

Research scientist exploring the role of the nervous system in C. elegans. People person, love traveling and networking. Views/opinions are my own.

[Sellegounder Durai @SDreamchaser08]

@chipbarnestruth @georgesantos @mcuban You need to ask that question to the US employers who give them H1B and invite them to US.

[Piali Sengupta @SenguptaLab]

Multiple postdocs out to academic/industry jobs + 2 grant NOAs in = open postdoc position.

Worms are great to work with, sensory biology is an endlessly fascinating topic, and we are a group of good humans. Please email if interested!

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

Calico Life Sciences announced today that their eIF2B activator investigational drug, Fosigotifator (ABBV-CLS-7262) was selected for the FDA START Pilot Program. This START Pilot Program was established to further accelerate the development of novel drug and biological products for rare diseases.

In this particular study, Fosigotifator (ABBV-CLS-7262) will be investigated in participants diagnosed with Vanishing White Matter (VWM) disease, an ultra-rare progressive leukoencephalopathy. VMN is caused by variations of the eIF2B subunit, an essential enzyme in the integrated stress response (ISR). When ISR is activated in a normal state, global protein expression is reduced (controlled) to enhance the expression of a signature set of stress response genes. But in VMN, the function of eIF2B is reduced, triggering chronic activation (uncontrolled) of ISR, leading to a loss of protein homeostasis (a hallmark of aging).

Other research groups have shown that ISR activity also increases with age and are currently studying the connection between ISR and brain aging. We've learned a lot about aging biology through rare diseases and hope to continue learning through these channels.

Congratulations Calico Life Sciences and AbbVie! We wish you the best of luck in your Phase 1b/2 trial of Fosigotifator.

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

Father’s Day is just around the corner!

Are you still shopping for a gift? Your A4LI membership unlocks many discounts on diagnostic tests, baseline screenings, and other longevity products that make great gifts that help our fathers and grandfathers take control of their health. If you’re not a member yet, we are offering a 25% discount on your membership this week. Use promo code DAD25.

Learn more about the benefits of becoming a member today (https://t.co/F0lQuOLeku) and let’s advocate for a long and healthy life for all!

Thank you to our partners for making this possible!
@TruDiagnostic @glycanage @NeuroAgeTX @prolonfmd @LNutraOfficial @OneSkinTech @DelavieSciences @optispan

[Sellegounder Durai @SDreamchaser08]

@deedydas @Dineshr2014 I found this math from other group discussing EB GC, does it mean anything? This is based on recent EB inventory released by USCIS yesterday.

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

The Alliance for Longevity Initiatives (A4LI) would like to remind everyone that we will be hosting a free to attend (open to the public) "Geroscience Education Reception" today, April 29th, from 5:30 pm to 8:00 pm at the Hay-Adams in Washington, D.C.

This event will feature speeches by Dr. Luigi Ferrucci (Scientific Director at the NIA), Dr. Paul Pasquina (Chair of Physical Medicine & Rehabilitation at USU), and Dr. William K. Smith (Founder of Longevity Labs) who will each discuss the biology of aging, recent therapeutic developments, and why the U.S. needs to adopt the “healthspan” approach to healthcare.

If you would like to attend, you can do so within the link here: https://t.co/n6AushJ8lM 

We look forward to seeing you there!

[Matt Kaeberlein @mkaeberlein]

If you're not already a member of the Alliance for Longevity Initiatives, please consider joining today.

https://t.co/LXFEGebvai

@theA4LI is doing important work and has shown the ability to put wins on the board. Help support longevity advocacy.

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

The United States is facing a shortage. An organ shortage. With approximately 120,000 Americans languishing on waitlists, and only 45,000 transplants performed annually, we have reached a critical juncture if we intend to solve this problem.

In light of this, the Advanced Research Projects Agency for Health (@ARPA_H) has recently unveiled its Personalized Regenerative Immunocompetent Nanotechnology Tissue (PRINT) program to combat this issue.

By utilizing cutting-edge bioprinting technology, PRINT aims to craft personalized organs on demand in order to significantly reduce wait times and improve access to life-saving treatments, as well as eliminate the need for lifelong immunosuppressive drugs.

You can read the full announcement here: https://t.co/ePRxhZiKJK

We at A4LI could not be more excited by this news. Not only does the PRINT program offer a tangible solution to the organ shortage crisis, it further demonstrates ARPA-H’s commitment to advancing biomedical technology for the betterment of public health. We can’t wait to see what else ARPA-H has in store for us in the near future.

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

A4LI would like to thank Longevity Science Caucus’ co-chairs @RepGusBilirakis and @RepPaulTonko for speaking at our inaugural #DCFlyIn

[Brenda Eap, PhD @beappbeapp]

Spring is off to a great start!

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

The moment we’ve been waiting for is finally upon us: Our inaugural D.C. Fly-In event is happening THIS WEEK, from March 20-21, 2024!

This week’s event marks a significant milestone in our journey towards our goal of extending healthy human lifespan.

We're beyond excited to welcome all participants to this historic event as we unite to shape a future where we can all live better for longer. Stay tuned for more updates!

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

The Alliance for Longevity Initiatives is proud to support @KennethBogner’s candidacy for Montana’s 2nd Congressional District. He will be a champion of the longevity industry on Capitol Hill.

To support Ken, check out: https://t.co/8nOoqpV4Sc

[Cellino @CellinoBio]

Proud to sponsor @theA4LI 's inaugural #DC Fly-In on 3/20-21 for combating aging-related #diseases & accelerating access to personalized #regenmed for all. Highlights: @ARPA_H Q&A, #LongevityScience Congressional Briefings & Keynotes on #CapitolHill.

👉 https://t.co/3s9ZJURHtB

[Brenda Eap, PhD @beappbeapp]

Excited to be offering discounts on @TruDiagnostic @glycanage @OneSkinTech @DelavieSciences @optispan and others with our A4LI Membership!

Get your tickets to @LongevityDublin @foresightinst @LongevityGL @LifespanIO events now!!

Thank you to our affiliates!

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

We’ve revamped our membership program at A4LI!

For only $50/year, members will receive A4LI swag, insider content/access to the longevity-political advocacy effort, as well as exclusive discounts to products, services and conferences in the longevity space.

While we believe that our mission is reason enough for members to join, we hope that the thousands of dollars in potential savings on our Discount Marketplace will encourage a broader audience to support our advocacy efforts.

Currently, we’re offering exclusive discounts to our members on:
- Conference tickets to the @LongevityGL’s Longevity Summit (CA), @LongevityDublin’s Longevity Summit Dublin and @foresightinst’s Foresight Vision Weekend
- Diagnostic tests from @glycanage, @TruDiagnostic and @GenerationLab_
- Baseline health services from @optispan and Vitaliti
- Products from @OneSkinTech and @DelavieSciences

We will be continuously adding to the list of longevity-related products for our members, so make sure to check back regularly!

Support our mission aimed at increasing healthy lifespan, and help us create a future where everyone can live better for longer – become a member today!

Link here: https://t.co/wLoFbtsU7A…

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

A4LI would not be who we are today without the help of hundreds of people and dozens of organizations that believe in what we are doing. That is why, every month, we use our platform to shine a spotlight on those that are making a tremendous impact on the longevity community.

For this month, we would like to recognize @PhenomeHealth for their efforts in promoting healthy aging.

Since their inception, Phenome has helped pioneer the use of data and cutting-edge research to combat prevalent chronic diseases such as cancer, cardiovascular disease, and Alzheimer’s disease. Their commitment to accessibility ensures that groundbreaking advancements in longevity science are accessible to everyone in order to foster a healthier and more resilient society.

At A4LI, we commend Phenome Health's unwavering dedication to promoting healthy aging. Their steadfast commitment to advancing biomedical technology underscores the essence of our shared vision: to empower individuals to lead longer, healthier lives. We extend our gratitude to Phenome Health for their invaluable contributions to the advancement of human healthspan, and we eagerly anticipate the continued impact of their groundbreaking work.

[The Alliance for Longevity Initiatives (A4LI) @theA4LI]

With just a little over two weeks to go until our inaugural D.C. Fly-In event on March 20-21, 2024, we're eagerly counting down the days! This gathering will unite leading scientists, policymakers, and industry influencers, driving crucial conversations on advancing initiatives that promote healthier human lifespans.

While registration for this event is now closed, we're excited to welcome all registered participants and look forward to the vibrant exchange of ideas and insights that will shape the future of longevity advocacy.

For those who aren't able to join us this time, stay tuned for future opportunities to engage with A4LI and our mission. Your support and involvement remains invaluable as we work towards a future where everyone can live better for longer.

[Poonam Soni @CodeByPoonam]

MIT University released free online courses.

No textbooks or fees required.

Here are 10 courses you don't want to miss:

[Sellegounder Durai @SDreamchaser08]

@CollinEwald Congrats Collin and team 🎊

[Sellegounder Durai @SDreamchaser08]

@DityaAakash @PeterDiamandis @xprize No that is not the goal of this grant money, read carefully, it is meant to provide healthy aging. Immortality is not goal of many researchers in the aging field, people often misunderstand the aging research due to some internet blogs and podcasts.