Longevity Global

Curated community of expert longevity researchers, entrepreneurs, and investors. Non-profit. We host events- Tweets by @DrGlorioso.

[Longevity Global @LongevityGL]

Curious about the latest brain breakthroughs in tech and biotech? Check out Longevity Global's Brain Optimization Summit during SF #TechWeek.

Sunday Oct 11
10a- 5p
MBC BioLabs
135 Mississippi St, SF

Register: https://t.co/T3lf7Ne8Ps

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Lowering Lp(a) Did Not Prevent Heart Attacks in the First Outcome Trial
What Lp(a) does, the study, where we stand with Lp(a) lowering interventions

The first large trial of a drug that lowers Lp(a) found no drop in heart attacks or strokes. Pelacarsen cut Lp(a) by 78% in more than 8,300 people with heart disease. After about 5 years, events were 12.3% on the drug and 12.1% on placebo.

The bottom line is that lowering Lp(a) with this drug, late in disease, did not prevent heart events. However, high Lp(a) remains a risk factor despite the failed trial.

🧬 About 1 in 5 people have high Lp(a), 125 nmol/L or more. It’s genetic, and a standard cholesterol panel doesn’t measure it.
📊 Genetic studies predicted that lowering Lp(a) this much with a drug would cut heart events by roughly 15 to 20%. Pelacarsen showed no reduction in this trial.
📉 HDL-raising drugs failed the same way, but for HDL the genetics never pointed to a cause.
🦔 Only humans, apes, Old World monkeys, and hedgehogs make Lp(a), and its normal job is still unknown.
👩 Lp(a) rises at menopause. Early evidence suggests hormone therapy can lower it.

My take. This is one drug, given for 5 years to people who already had heart disease. Olpasiran and lepodisiran lower Lp(a) further, and prevention trials are underway. For women with high Lp(a), I recommend considering the type and timing of hormone therapy, with transdermal estradiol and micronized progesterone started within 10 years of menopause. For people with very high Lp(a) whose heart disease keeps progressing despite treatment, lipoprotein apheresis, which filters Lp(a) out of the blood, may be an option to discuss with a lipid specialist.

Link to full post: https://t.co/33CkdfLeGg

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

A new observational study points to protective effects of estrogen (both HRT and birth control) for brain health in women, particularly in APOE4 carriers.

Alzheimer's is 2X more likely in women, even after taking into account that women live longer on average. Declining hormones during perimenopause and menopause could explain this in part.

While it does not establish causation, this study adds to growing evidence that women should be on HRT starting in perimenopause to prevent dementia. (Something I myself am doing and strongly advocate for).

"Women with higher lifetime estrogen exposure had less cerebrovascular pathology, a cohort study in Sweden showed.

A longer reproductive span was associated with 8% lower odds of having two or more signs of cerebral small vessel disease (OR 0.92, 95% CI 0.86-0.99), reported Anna Marseglia, PhD, of the Karolinska Institutet in Stockholm, and co-authors.

Menopausal hormone therapy was also linked with lower cerebral small vessel disease burden (OR 0.41, 95% CI 0.20-0.81) and with increasing white matter integrity (ß=0.28, 95% CI 0.06-0.50), Marseglia and colleagues wrote in Neurology.

Among APOE4 carriers only, menopausal hormone therapy was associated with greater cortical thickness in brain regions typically affected by Alzheimer's disease (β=0.38, 95% CI 0.01-0.76).

Women who used oral contraceptives earlier in life and menopausal hormone therapy later had the lowest small vessel disease burden (OR 0.31, 95% CI 0.12-0.83) and the greatest white matter integrity (β=0.45, 95% CI 0.12-0.78), the researchers said."

The news article:https://t.co/Ac3Q0M5VCC
The study: https://t.co/XkbvSthn7V

[Longevity Global @LongevityGL]

RT @DrGlorioso: Join NeuroAge Therapeutics and Longevity Global for our third longevity group fitness class in SF Nov 18th. This class is p…

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

We've extended early bird pricing ($199) while tickets last for the #Younger Biological Age Contest Kick Off Jan 11-12th in San Francisco. Whether or not you are participating in the contest, you won't want to miss this stellar speaker line up of the top longevity doctors, scientists, and entrepreneurs giving you practical (and scientifically backed) advice on how to become your youngest and healthiest self.

Get tix: https://t.co/dJfeAFBj7o
Learn more: https://t.co/bO1038kZQK

Speakers include: Ryan Smith, Ray Mak, Raghav Sehgal, PhD, @RonjonNag, Sunjya Schweig, MD, Alan Alexander, Momo Vuyisich, Kathleen Jordan, MD, Amy B Killen MD, Paul Coletta, Steve Horvath, Eric Verdin, Bobbie Kumar MD MBA FAAFP, Kayla Barnes-Lentz, Nikolina Lauc, Hillary Lin, MD, David Barzilai MD PhD MBA MS DipABLM, David Harry Stewart, Leo Grady, PhD, Melissa Keinath, Ph.D., FACMG, Vera Mulyani. M Arch. MA, and Valerie Orsoni.

Big thanks to our partners: @TruDiagnostic, Vero Bioscience, Inc., @glycanage , STARLA, @rythm , @CosmicaBiosc , @BrainkeyAI , and @BodySpec .

[Amy Proal, PhD @microbeminded2]

Persistent viral, bacterial, parasite & other #infections are increasingly implicated in chronic diseases and aging

We’ve united the top scientists, biotech innovators, and other stakeholders working to study & treat these infections into a 3-day Summit.

Come watch the talks virtually at the link below! 👇

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Want a discounted way to fully measure your biologic age and motivation and personalized recommendations to reverse your aging?

Join the #Younger Biological Age Competition and spend 6 months competing to rejuvenate your brain, face, organs, and functional age. Become your youngest and healthiest self.

The next 14 competitors to sign up for the Ultra tier or Ultra plus retreat tier are eligible for a complimentary LED light mask through our partner, Starla.

Learn more and sign up here: https://t.co/YGquzBgodq

[Longevity Global @LongevityGL]

RT @DrGlorioso: I was thrilled to be interviewed on the AGEIST podcast about NeuroAge Therapeutics and the #Younger Biological Aging Contes…

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

It was a pleasure to speak at @LongevityGL Brazil Chapter's inaugural event. Big thanks to Chapter Director, Dr. Vania Assaly, and Assistant Director, Clara Barros for the invitation. I am very excited for more to come in Brazil.

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

@LongevityGL is honored to welcome Dr. Jens Eckstein to our Scientific Advisory Board. More exciting news to come!

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

We are excited to announce that BrainKey will be joining the #Younger Biological Age Competition as an official testing partner for Ultra Competitors. Brainkey brain MRIs give a brain age based on 18 different brain region volumes, test for white matter hyperintensities, and are preventative screening for tumors and aneurysms. Up to 3% of people have a brain aneurysm that they don't know about, which could be potentially fatal, and aggressive brain tumors caught early have much higher survival rates. These are great reasons to get a brain MRI.

Younger is a 6 month competition to lower the biological age of your body, brain, skin, organs, and function. The competition is rolling and entries are accepted through mid January 2027.

Did you know that you can grow your brain back to be bigger? That has been shown in clinical trials of exercise, video games, and other interventions. Younger Ultra Competitors are competing to do just that in 6 months.

Register as an Ultra competitor today: https://t.co/YGquzBgodq

BrainKey joins our other prestigious partners, @TruDiagnostic , @Vero_Bioscience , @glycanage , Harvard's FaceAge, STARLA, and @rythm.

We are also welcoming BrainKey CEO, Owen Phillips, Ph.D., as faculty for our events.

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

We are excited to announce that STARLA Skin will be joining the #Younger Biological Age Competition as an official solution partner for Ultra Competitors. Starla has red (and other colors) light masks that may be beneficial for face aging. We will be putting that to the test for competitors that choose to participate in this study and receive a free mask.

Younger is a 6 month competition to lower the biological age of your body, brain, skin, organs, and function. The competition is rolling and entries are accepted through mid January 2027.

A major goal of the competition is to test potential longevity interventions using decentralized clinical trials and multiple aging clocks and then publish the results. Red light therapy is just the beginning.

Register as an Ultra competitor and receive a free light mask while quantities last: https://t.co/YGquzBgodq

Starla joins our other prestigious partners, TruDiagnostic, Vero Bioscience, Inc., GlycanAge, Harvard's FaceAge, and Rythm.

Big thanks to Starla CEO, Icey Roongpiti ✨ , for reaching out and providing masks.

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Out in MIT Technology Review

A new contest pits competitors against each other in a race to biological youth
And I'll be joining them.

By Jessica Hamzelou

This week, I officially signed up for an unusual competition. One that rewards competitors for getting younger.

I recently turned 40, and I don’t need reminding that both time and my chronological age only tick forward. But this game is focused on competitors’ biological ages—figures that are meant to provide a better way to measure the age-related health of our organs and bodies.

Over a six-month period, around 500 of us will try to reverse our biological age as measured in a bunch of different ways. There’s even a leaderboard! The winners will include the person who shows the greatest difference between their chronological and biological age, as well as the person who manages to reverse their biological age the most.

The competition is the brainchild of the neuroscientist and physician Christin Glorioso, who is also founder and CEO of NeuroAge Therapeutics. The company offers tools to track brain health and aging and is running a trial to find out if biological brain age can predict the onset of Alzheimer’s disease.Glorioso says she has several goals for the Younger contest. The first, she tells me, is to “explain to the world what aging clocks are.” Regular Checkup readers will be familiar with these tools, but for the uninitiated, they are basically designed to measure biological age.

Many measure chemical signatures that form a layer on top of our DNA and seem to change with age. But others might involve looking at proteins or lipids in blood. Some are designed to measure functional health, while others predict when a person will die. There are more than a hundred clocks out there, and they probably each capture a specific aspect of the biological process of aging.

These clocks are proving very useful for scientists, who use them to study aging and development in humans and many other species. But using them to estimate the biological age of an individual person is more controversial. They’re just not good enough for that yet.

Part of the problem is that we don’t really understand what each clock is capturing. Glorioso hopes that data collected through the Younger contest might help answer that question. She’s hoping to generate “the world’s most comprehensive clock dataset.

Some longevity clinics try to get around the limits of biological age testing by using multiple clocks. That’s this competition’s approach too.

Full article: https://t.co/f9OgxB7xtQ

Thanks to our partners: Raghav Sehgal, PhD, Ryan Smith, Ray Mak, Owen Phillips, Ph.D., Nikolina Lauc, Melissa Keinath, Ph.D., FACMG, Paul Coletta, Icey Roongpiti ✨, David Furman

[Aman Kumar @amankrsingh03]

Spent the day at the Brain Optimization Summit 2026 in SF, with a room full of people obsessed with the brain. 🧠

Brain stimulation, neurotechnology, cognitive aging, longevity. So many interesting approaches to understanding the brain. Loved meeting folks building in this space.

Neurotech is going to get VERY interesting in the coming times.

@LongevityGL

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

What Can a Biological Age Test Actually Tell You?
Experts weigh in on the tests’ current accuracy and usefulness.

Today in the NY Times, Harvard Professor and Longevity Global's Head of Research and a key investigator in the NeuroAge Therapeutics's #Younger BioAge Contest, Raghav Sehgal, PhD is quoted.

From the article:

"How old are you? How old do you feel? Are those two numbers the same?

Biological age tests have validated what many of us sense intuitively: Our cells don’t always match our birth certificates. As these tests have evolved over the past decade, longevity researchers have started using them to identify what behaviors and conditions cause people to age faster and whether there are interventions that can slow the process down...

“In a way, when the biological age is older than the chronological age, you are at high risk of adverse health outcomes,” said Dr. Luigi Ferrucci, the scientific director of the National Institute on Aging. “When your biological age is younger than the chronological age, you’re kind of protected against those health outcomes.”...

“You can measure the changes in these blood cells,” said Tony Wyss-Coray, a professor of neurology and neurological sciences at Stanford, but “you don’t see changes that might happen in neurons in your brain, or in liver cells or in the pancreas.”

To try to solve for this, instead of looking at DNA, Dr. Wyss-Coray and other researchers have started testing blood samples for thousands of proteins that are released from different tissues. That enables them to evaluate how multiple types of cells or organs are doing, rather than inferring someone’s head-to-toe health from just their white blood cells.Some experts think this approach will provide more valuable and actionable information, because while the idea of distilling the health of your entire body into one number is seductive, it’s probably more useful from a medical standpoint to know which organ is going to cause problems first."

🥇 The Younger Contest aims to understand how the various clocks move together, can be useful for clinical trials, and are moved by interventions, moving the next generation of clock building forward in an actionable way for the public.

The NY Times article: https://t.co/8DY71pE85o

The Younger Contest: https://t.co/YGquzBgodq

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Looking forward to speaking this Thursday on the Future of Longevity: Research, Innovation, Investment.

RSVP: https://t.co/rbpVOr66jW

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

It's the last week of early bird pricing for the 6th annual Longevity Global Summit at the Buck Institute for Research on Aging, Dec 9-10.

Each year I put my ear to the ground, comb the scientific literature and the press releases, and go to conferences to hear the newest and coolest advances in longevity. Then I get the incredible people/teams behind them to come speak to us in a beautiful space at an institute entirely devoted to extending healthy lifespan.

This year's lineup is no exception. The speakers are outstanding and some of the most important longevity voices of 2026. I'm particularly excited that some the longevity therapeutics companies have matured to be in clinical trials, that GLP1 drugs extend mouse lifespan, we'll hear about the maturing field of aging biomarkers, peptides and regulation, and from longevity physicians on the bleeding edge of medicine.

📣 💲 We get the top investors to come and media outlets to cover it. We put all of these incredible people in the same room and at a private VIP dinner. Many solutions have been baked, inspired, funded, and brought forth into daylight at the Longevity Summit. Raises in the $10s of millions and angel investments have directly resulted from this conference year after year.

Get tickets now before prices go up: https://t.co/Jlohi96mo1

Speakers include: Eric Verdin, Ronjon Nag, Janine Sengstack, Matthew "Oki" O'Connor, KRISTA RAMONAS, MD, FAAO, Ashley Zehnder, Neil Panchal, DO, Michael Snyder, Jonathan Swerdlin, Aditya Varna Iyer, Dean Ornish, M.D., Alan Alexander, Armand Cognetta, Irit Rappley, Tom Zuber, Marco Quarta, Susanna Rosi, Kevin Caldwell, David Furman, Brenda Eap PhD, Danica Chen, Vera Mulyani. M Arch. MA, Abhijit Kale Ph.D., David Scieszka.

[Rapamycin News @RapaNews]

Last week for Early Bird Pricing - Sign up Today.
https://t.co/velwmqed6z

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Next Sunday as part of SF TECH WEEK by a16z @LongevityGL presents our 2nd annual Brain Optimization Summit graciously hosted by MBC BioLabs.

We have an incredible lineup for you including talks by Ronjon Nag, Mike Olson, Paola Telfer, Antonio Forenza, PhD, Natalise Kalea Robinson, Laura Hix Glickman, PhD, Ramses Alcaide, Nathan Brady, Tom Zuber, John Forrest, Salah Mahmoudi, Brian Tsui, and Dobri Kiprov.

Still a few early bird tickets left.

RSVP: https://t.co/GbuadHkB7T

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Can Essential Oils Like Rosemary Lower Dementia Risk?

Someone mentioned rosemary to me this week as a way to protect the brain, so I went through the research on essential oils and dementia.

Losing your sense of smell is a well-replicated early sign of higher dementia risk. Early evidence on adding scents to daily life is building, although no study has yet shown that it lowers dementia risk.

A few findings people might not know 👇

👃 In a 12-year Swedish study, older adults with a reduced sense of smell had about twice the risk of developing dementia. Smell loss plus the APOE4 gene raised the risk close to fourfold.
🧠 Smell signals bypass the thalamus and reach the entorhinal cortex, the gateway to the hippocampus, within one or two connections. Tau tangles appear early in these same regions in Alzheimer's.
🌿 Rosemary contains 1,8-cineole, a compound thought to block the same enzyme that the Alzheimer's drug donepezil targets. The studies so far are small and measured short-term performance.
🌙 A UC Irvine trial diffused a different essential oil each night for six months in 43 healthy older adults. Memory scores and a memory-related nerve fiber pathway improved compared with controls.
🦠 COVID-19 infects the support cells in the nose. In older adults, lasting smell loss after infection tracked with more cognitive problems months later.

A larger trial that tracks Alzheimer’s blood markers over several years would show whether regular scent exposure changes the course of brain aging or improves how the brain functions.

My take

In the meantime, if you like essential oils, they fall into the bucket of low risk and plausibly could help, which is a green light for trying them from me.

Link to full post: https://t.co/0JPPl8mRdD

[Christin Glorioso, MD PhD🏳️‍🌈 @DrGlorioso]

Younger founder Christin Glorioso on turning a six-month competition into a side-by-side trial of aging clocks.

Out today in https://t.co/tEH6caogGA

Younger is a six-month contest to measure and reverse biological aging, hosted by @NeuroAgeTX with @TruDiagnostic, @Vero_Bioscience , Inc., Harvard FaceAge, BrainKey, and Dr Raghav Sehgal, PhD's lab at Harvard. The science behind the testing comes from Stanford, Harvard, MIT, and Yale. Every competitor measures their biological age across brain, body, and face, makes whatever health changes they choose for six months, then repeats the same measurements. Awards go to the most years turned back over the six months and to the youngest biological age relative to chronological age. Reporters, longevity company founders, and scientists are competing alongside members of the public, and many are posting their results as they go.

The live kickoff is January 11 and 12, 2027 in San Francisco, with talks from speakers including Dr Steve Horvath, Dr Eric Verdin of the Buck Institute, Dr. Amy B Killen MD,  Dr Ray Mak, Dr. Hillary Lin, MD, Kayla Barnes-Lentz, Dr. Kathleen Jordan, MD, Dr. Momo Vuyisich, Dr. Sunjya Schweig, MD, Nikolina Lauc, Paul Coletta, David Barzilai MD PhD MBA MS DipABLM, Saranya Wyles, M.D., Ph.D., Ronjon Nag, Bobbie Kumar MD MBA FAAFP, David Harry Stewart, and Dr Raghav Sehgal. Retests are due by August 1, 2027 and winners are announced at the finale in November 2027. A single entry covers either an in-person or a virtual track at the same price and with the same testing, so competitors can take part from anywhere. Along the way they get personalized recommendations built from their results, an online community, and monthly webinars.

Signup for Younger: https://t.co/YGquzBgodq

Full article: https://t.co/KsEkjOqJFC